This could be another great GH potentiator. I have attached the abstract as well as an image of the graph that shows the ghrelin group as opposed to the control. The nice thing about this stuff is the dosages used in the study were 1ug/kg*bw, which means I would only be taking 80ug if I followed this study. This is what I have been spending most of my time on lately as you guys have probably noticed; the entire GH/IGF-1 axis.
ABSTRACT. An endogenous ligand for the GH secretagogue-receptor (GHS-R) has been recently
purified from rat and human stomach and named Ghrelin. It has been demonstrated that Ghrelin
specifically stimulates GH secretion from rat pituitary cells in culture as well as in rats in vivo. In this
preliminary study, in 4 normal adults [age (mean±SE): 28.6±3.5 yr; body mass index (BMI): 22.3±2.1
kg/m2] we administered 1.0 μg/kg Ghrelin or GHRH-29 to compare their GH-releasing activities in humans.
In all subjects Ghrelin induced a prompt, marked and long-lasting increase in circulating GH levels
(peak: 107.9±26.1 μg/l; AUC: 6503.1±1632.7 μg/l/h). The GH response to Ghrelin was clearly higher
(p<0.05) than that after GHRH (peak: 22.3±4.5 μg/l; AUC: 1517.5±338.4 μg/l/h). In conclusion, this
preliminary study shows that Ghrelin exerts a strong stimulatory effect on GH secretion in humans
releasing more GH than GHRH.
(J. Endocrinol. Invest. 23: 493-495, 2000)
ABSTRACT. An endogenous ligand for the GH secretagogue-receptor (GHS-R) has been recently
purified from rat and human stomach and named Ghrelin. It has been demonstrated that Ghrelin
specifically stimulates GH secretion from rat pituitary cells in culture as well as in rats in vivo. In this
preliminary study, in 4 normal adults [age (mean±SE): 28.6±3.5 yr; body mass index (BMI): 22.3±2.1
kg/m2] we administered 1.0 μg/kg Ghrelin or GHRH-29 to compare their GH-releasing activities in humans.
In all subjects Ghrelin induced a prompt, marked and long-lasting increase in circulating GH levels
(peak: 107.9±26.1 μg/l; AUC: 6503.1±1632.7 μg/l/h). The GH response to Ghrelin was clearly higher
(p<0.05) than that after GHRH (peak: 22.3±4.5 μg/l; AUC: 1517.5±338.4 μg/l/h). In conclusion, this
preliminary study shows that Ghrelin exerts a strong stimulatory effect on GH secretion in humans
releasing more GH than GHRH.
(J. Endocrinol. Invest. 23: 493-495, 2000)
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