I also know that systemic IGF-1 is not so good if you have tumors. It's also known to cause GH gut or perma-gut. IGF-1 likes to bind to things other than muscle cells as well which can cause some problems, however minor or major they may be. Because of this, I think GHRP's are a safer method, since they don't cause systemic GH levels. They simply trigger the same process that already occurs in the body allowing it to "pulse" the hormone in a very natural way.
Seriously, let's give this thread back to the OP now. At least we did stay on topic, lol.