IGF DES 1,3 questions
- 12-03-2010, 12:18 AM
IGF DES 1,3 questions
I have spent some time trying to research the DES version of igf. I have used lr3 multiple times but can't seem to find any info on DES. I tried to search here. I do know it's a variation with an altered amino profile that is produced naturally at certain times. What I can't find is an average dose. I can't find info on reconstitution. A site that sells it claims it's stable in .06% AA for 3 weeks. I thought AA was only for lr3 because of the lr3. Does anyone have any experience with DES, and does anyone know the recomendation for reconstitution and dosage? I typically use 40mcg with lr3. I have read all the info on it's profile so not really looking for that type of info. Thanks for any help.
- 12-03-2010, 05:28 PM
12-03-2010, 07:49 PM
12-04-2010, 01:35 AM
12-04-2010, 01:36 AM
And if anyone else has any input feel free to chime in. It can't hurt to gather as much input as possible.
12-04-2010, 10:25 AM
12-04-2010, 11:30 AM
Lol. Trust me, if I didn't get deals on all this stuff I wouldn't be using it either. Luckily for me I got good amounts of all kinds of peps and aas at the same time. I'm not really expecting anything more from DES than I do with igf but I figured it was worth trying and changing things up.
12-04-2010, 06:12 PM
12-04-2010, 09:03 PM
12-04-2010, 10:41 PM
12-04-2010, 11:02 PM
12-06-2010, 12:22 PM
Solubility: It is recommended to reconstitute the lyophilized IGF-I Des(1-3) in 100mM Acetic acid not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Stability: Lyophilized IGF-I des(1-3) although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGF1 des-1-3 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Pulled from http://www.prospecbio.com/IGF-I_des1-3_Human_2_20
12-12-2010, 03:00 AM
Here's some info I found on DES IGF. Think this is all over the net but posted in case anyone is interested.
DES (1-3) IGF-1 (NOT THE SAME AS IGF-1)
Most athletes have heard of IGF-1 (insulin like growth factor-1) and the amazing anabolic effects it has been reported to have upon Protein based tissue such as muscle. Des (1-3) IGF-1 is over 10 times (1000%) more anabolic than IGF-1. Now that is amazing!!
IGF-1 is actually produced from both insulin and growth hormone in the Liver and other tissues. IGF-1 is made up of 70 amino acids in a chain. Well, when a clever chemist removes the last 3 amino acids in the IGF-1 chain (the N-terminal tri-peptide) it becomes Des (1-3) IGF-1 and 1000% plus more anabolic. Why? IGF-1 circulates through our blood stream and tissue 24 hours a day, 7 days a week. Unfortunately, most of the IGF-1 is inactive because it is bound by another Protein called (get this) IGF-1 Binding Protein-3, or IGF-1-BP-3 for short. Since bound hormones can not fit into and trigger a receptor-site, the majority of circulating and muscle IGF-1 can not trigger an anabolic stimulus. Like tons of cellulite in a o movie (who watches those?) there is little good stuff happening. However, when IGF-1 is altered and becomes Des (1-3) IGF-1 the binding Protein IGF-1-BP-3 can not bind to it and it is totally active. Another reason Des (1-3) IGF-1 is so potent is its unique ability to fit into lactic acid altered IGF-1 receptor sites. (YUP) When we train we burn carbohydrates as a fuel to make cellular ATP. When cells switch to this ATP pathway, the by-product is Lactic Acid. This is of course the cause of most of the burn we feel during intense or higher rep sets. Well, the lactic acid build-up is called acidosis, and it destroys the shape of some receptor-sites for period of time. Therefore some anabolic/anti-catabolic hormones have difficulty merging with their respective receptor- site and triggering a response (such as even unbound IGF-1). Not so with Des (1-3) IGF- 1, the super growth factor. It fits into the IGF-1 receptor-site even after acidosis. Des (1- 3) IGF-1 is unbound, over 10 times more potent than IGF-1, and it picks receptor-site locks. Too bad it has only a few minute active-life.
Did you know that our body's make Des (1-3) IGF-1 naturally? Most un-informed individuals claim other wise, but it is true. When an athlete trains lactic acid builds up in muscle tissue. As we know, there is always IGF-1 / GH present in the blood stream and tissues (including muscle) from prior work-outs and other metabolic factors. That lactic acid burn triggers IGF-1/GH secretion from both prior and present work-outs. Unfortunately, lactic acid destroys some of the IGF-1 present in muscles being trained. But wait, this is good too!
Lactic acid also cuts (truncates) the last 3 amino acids off the 70 amino acid chain of "some" of the surviving IGF-1 and creates Des (I-3) IGF-1. So acidosis increases GH/IGF-1 production in the Liver, "unbinds" IGF-1 locally in the muscle being trained (burned), destroys some of the IGF-1, and converts some IGF-1 into Des (I-3) IGF-1. Huh, good deal. And the synthetic form of this super anabolic stuff is beginning to show up on the black market more frequently.
The Protein binds less well to IGF-binding proteins and is generally approximately 10-fold more potent than IGF-1 at stimulating hypertrophy and proliferation of cultured cells. REFERENCES: Ballard FJ Des(1-3)IGF-I: a truncated form of insulin-like growth factor-I. International Journal of Biochemistry and Cell Biology 28(10): 1085-1087 (1996)
01-27-2011, 09:12 AM
i suspect that the lactic acid thing is completely made up
anyway all that there really is out there on this igf-1 variant is that it is ten times as potent as igf-1 in cell cultures. we are complicated organisms however not cell cultures so who knows what the stuff will or will not do for humans. probably just like the R3
02-01-2011, 06:21 PM
So I've been away for a while DES is definately stronger and they way to go with igf. I used 20mcg three times a day. There is a huge difference between the two. With DES, I couldn't even brush my teeth without getting a pump. Very vascular. Good stuff. I will still use lr3 until my stash is gone but then it's DES for now on. I was also able to eat high carbs and stay lean and only lost 2lbs during pct. It had to have helped
02-02-2011, 08:38 AM
her 2res4, i know you said high carbs, but how high and when with this? Just trying to see if timing is diff than with lr3. I see many going pre wkout with this, which I am assuming means they are not eating for at least an hr after the shot, and maybe not for an hr or so before. I personally hate working out on a stomach full of carbs, makes me sluggish, I like to eat an hour to an hour and a half before working out, just wondering if this stuff fits that schedule. thanks for the update
02-07-2011, 02:43 AM
02-07-2011, 09:52 AM
02-07-2011, 12:45 PM
02-07-2011, 12:49 PM
02-07-2011, 01:09 PM
02-07-2011, 03:33 PM
the trick with the lr3 and des i believe is finding some way to deliver it in a depot fashion. that is, to deliver it so it stays put at its injection site and slowly releases in a time dependent fashion. That may end up resulting in anabolic effects in the surrounding muscle tissue where it was injected
02-07-2011, 03:49 PM
02-07-2011, 04:05 PM
02-07-2011, 07:54 PM
02-08-2011, 12:09 AM
I'll be giving it a run if USPS ever delivers my da*N package. I liked LR3, and felt it helped with endurance, and nutrient uptake... altho you could get the same affect from insulin i suppose. It did seem that i could be more lax in my carb intake and not gain fat.
02-08-2011, 07:36 AM
most times these things are not what they are hyped to be, but if they actually help with glucose disposal, give a nice pump, and shed some fat, for the price compared to buying otc junk to do these same things, except the otc probably not work as well, it is still a good deal.
think about the cost of buying a prewkout/pump product, a gda, and a non stim fat burner, vs igf. Now think about the effectiveness between them. IGF is a better deal, although there is the possibility it may be a little more risky, maybe not though, the use of this is still pretty new, so time will tell.
02-09-2011, 01:57 AM
I think it's better than lr3. I dont believe it's doing what it's really supposed to. The way I look at this is basically a safer insulin. I got almost immediate pumps during training. There was also increased vascularity. Now there is the opinion that this is simply expensive insulin and I can see that and I hope that's exactly how it's working.
Look around on some other forums and there are some good threads on DES. The pump and full feeling remained all night after training
I don't believe it's really causing hyperplasia but to me I noticed this to be stronger than lr3 almost immediately. I don't know about 10 x stronger but definately stronger. And if you look around it is actually cheaper. I'll just say I paid 1/3 the average price of lr3
I just think this is something to add to my arsenal. I don't think it could replace AAS but it's better than any OTC product I have ever used and I think it's good in combination with AAS. I also see igf as a great inclusion for pct. If it works to shuttle nutrients then it's very helpful.
I do agree that igf has not lived up to the hype by any means but I personally have found uses for it and will continue to use it. DES during cycle and I'll save lr3 for post cycle
I also believe igf, follistatin, myo propep, and the gh peps are all very benificial on and off cycle. I personally think these can help maintain weight, strength, endurance while off cycle. They give an extra edge with out the side effects and help aid in recovery.
Follistatin is my next experiment. I have read a lot of logs of guys getting pretty good results from this but it also cause lethargy. That's the other thing I noticed with DES, I didn't get the lethargy I did from lr3.
02-09-2011, 02:04 AM
Patric I appreciate all your comments. I to am skeptical of igf but still like it and have found a use for it. If you compare to all the reported effects, then I think it fails horribly. DES in my opinion just provides a stronger effect than I get from lr3, so my post may be misleading but this was great news to myself because I like to use it. It wasn't meant to say this variant actually works like igf is supposed to if that makes sense
02-10-2011, 12:57 PM
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