PapaPump's CJC-1295/GHRP-6 6-month Run
- 10-11-2008, 03:52 PM
- 10-11-2008, 03:54 PM
- 10-11-2008, 03:56 PM
10-11-2008, 04:05 PM
10-11-2008, 04:18 PM
The odd thing about it is that I'm not having problems with the 3 GHRP-6 shots I do a day...only with the CJC...it could be because I just reconn'd the CJC so we will see after the shot tonight...
10-11-2008, 04:55 PM
10-11-2008, 06:14 PM
It may also be worth looking into new pins like those that Papa noted. I've noticed a huge difference between my cheapo (30ga) and Terumo (29ga) pins. Oddly enough, the latter slide in much more easily.
10-11-2008, 07:43 PM
BTW guys, I have not taken any CJC or GHRP since yesterday morning. None today either. I feel so much better...no high blood pressure! Love not having that freaking headache. I will do my "500 mcg" shot of one of the vials. But you know there is a dilemma at hand, correct? If I don't know the true mg/vial, how am I supposed to know how much do draw out? I will be pulling from 1mL (each vial will be reconned w/1mL BW). I will standardize that part at least.
I will give the supplier the benefit of the doubt and assume the products were labeled correctly. Now, with that assumption, I plan to draw 25 units (25 ticks) from the assumed "CJC-1295" vial. That will yield either: A) 500mcg (CJC) or B) 1,250mcg (GHRP-6). Whether it's CJC or GHRP, I won't know unless there's a "flushing" feeling (CJC) or some other feeling from mega dosing GHRP-6 (????).
Dat, is there any issue w/dosing potentially that much GHRP-6? I know it's way above the usual dose.
EDIT: My other option is to dose so that my max mcg will be 500mcg and that will have me pulling 10IUs which is either: 500mcg or 200mcg. Again, it could be CJC or GHRP...can't be sure.
10-11-2008, 09:00 PM
I havnt done either.... so take this with agrain of salt but from what Ive read, GHRP-6 at that high a dose may lead to tingling in the extremities and increased hunger.... Def think you should look for flushing or no flushing though considering Im not sure if the tingles can come with CJC as well....
10-11-2008, 11:39 PM
I can speak personally though, and say that 200mcgs of cjc hasn't yet given me the "flush" feeling. I'm positive my stuff is legit as well. Assuming there would be no damage done if you did megadose on the ghrp, I'd stick with pulling 25 units. I don't post a lot around here, but I am a chronic reader. Flushing is by far the most prominent, and consistently seen side effect between the two peptides that I've observed from reading other's posts. I definitely agree on this being your best bet.
10-12-2008, 12:18 AM
10-12-2008, 01:10 AM
10-13-2008, 12:04 AM
10-13-2008, 09:47 AM
Anyone have recommendations on how to best counter any potential spikes in prolac and/or cortisol? Please keep recommendations on the legal side (no Rx). Thanks everyone!
Note: As soon as I have a plan for dealing w/prolac & cortisol, I will do the "500mcg" dose. I just don't want to find myself in an ugly situation w/o a remedy in hand.
10-13-2008, 12:21 PM
10-13-2008, 12:34 PM
10-13-2008, 12:40 PM
On that note...
I like PS (Phosphatydilserine) the best for Cortisol control. Min of 800mg/day, but I tend to go with 1g (normally just in PCT or when low cal/Cutting). I personally do not like messing with 11BetaHSD-1 for cortisol control.
PS actually works on the hypothalamus affecting CRH and pituitary ACTH output.
This actually makes me wonder right now if the method of action of PS would be efficient on this level of the axis as GHRP will exhibit its counter action this level as well.
I am not sure if just blocking the exess cortisol conversion at the 11BHSD-1, from the GHRP mediated ACTH increase, would be the better route to go.
Anyhow, for PRL you could go with Cabergoline, which is Rx as Dostinex, BUT non RX if bought for Research. Its up to you how you define not wanting the non RX route
Best herbal/vitamin would be L-dopa (Mucana) or 1-Carboxy even though I believe they are the same (Lets not debate this one as its been overdone).
I would also add a good dose of EGCG and EGC from Green Tea as it is has been shown they are inhibitors of dopa-decarboxylase. You definitely do not want peripheral conversion of large amounts of L-dopa into dopamine as it will then not make it past the BBB and will exert its side effects systemically. (Last thing you are wanting right now is more BP issues I assume).
Also, other than that P-5-P (pyridoxal 5 phosphate) is great. The active coenzyme form of B6 (pyridoxine hcl) which will not cause the sides of higher doses of B6.
Sorry for the rant.
PS- I still do not think you need anything for this
10-13-2008, 12:58 PM
EDIT: But, I think running anti cortisol and PRL during CJC/GHRP runs has its merits according to the PDF study Dat posted (Based on Bobaslaw's post of the study) in the link above (post #96), titled, "Hexarelin-Induced Growth Hormone, Cortisol, and Prolactin Release: A Dose-Response Study".
10-13-2008, 01:05 PM
The cort and PRL profiles are much different between GHRPs/Hex. Hex has the worst impact. GHRP-6 is not significant enough for the doses we use in the protocol. GHRP-2 is in between...
Edit: This was recently discussed with Dat, but I cannot remember which thread or Forum. The info on this is out there though
Edit2: Also, keep in mind that studies show that the (GHRP/Hex) increases in Cort and PRL are blunted by concurrent administration with GHRH if the secretagogue doses do not greatly exceed 1mcg/kg.
10-13-2008, 01:11 PM
10-13-2008, 04:32 PM
Plus you don't want to kill cortisol levels. It may even be beneficial to have high/normal range on cycle:
There is synergy between the two hormones involved in GH synthesis.
"RESULTS: ...cortisol...in the presence of thyroid hormone, increased the growth hormone synthesis rate an additional 2- to 5-fold"
"DISCUSSION: ...The synergistic control of growth hormone synthesis by T3 and cortisol appears to occur independently of one hormone modulating the cellular distribution or concentration of the receptor for the other hormone (12). Because thyroid and glucocorticoid hormones appear to act at the nuclear level, it seems likely that both hormonal receptors act at the genome in a concerted fashion to increase the accumulation of GHmRNA.
...suggests that both hormones interact to modulate the growth hormone response by a pretranslational mechanism, presumably at the level of the growth hormone genome.
SOURCE: Thyroid and glucocorticoid hormones synergistically control growth hormone mRNA in cultured GH1 cells, LAWRENCE E. SHAPIRO, Proc. Nati. Acad. Sci. USA, Vol. 75, No. 1, pp. 45-49, January 1978
ABSTRACT We have previously demonstrated that thyroid hormone controls growth hormone synthesis in GH1 cells and that the induction of the growth hormone response by glucocorticoid appears to be highly dependent on thyroid hormone action. Thyroid hormone induces growth hormone synthesis approximately 5- to 20-fold and cortisol increases this response 2- to 6-fold further. Long-term kinetics of the growth hormone response show that, without added thyroid hormone, cortisol can induce a small-growth hormone response after 48 hr of incubation....
10-13-2008, 05:04 PM
I will also mention that the GHRP and CJC can in separate ziplock bags and w/in each of the two bags was an HPLC analysis of the product. I went back and checked and the print off for CJC was in the bag labeled CJC (same for GHRP). Hmmm.....Is this 500mcg dosage thing really necessary or should I just dose everything down a bit to let my body adapt to the increased GH? My hands were achy the past few days (just making note here). IMO, I look bigger and am moving very good weight in the gym even after my 2 week "resting" period (lifted lighter and less frequently).
Or is it just fine to do my planned "500mcg" dose and see what happens? Sort of in analysis paralysis here.
10-13-2008, 05:07 PM
It certainly is food for thought to the stereotypical misconceptions that certain hormones are solely attributed as "negative" (ex. cortisol, estrogen, etc).
Unless levels of any particular hormone are extreme (for whatever reasons), leaving the body to determine the optimal balance seems ideal IMO.
10-13-2008, 05:07 PM
10-13-2008, 05:35 PM
10-13-2008, 05:41 PM
10-13-2008, 05:41 PM
There are no negative hormones. Prolactin even has a role to play.
In the end the body has its sh1t together far more than you, I or the $49.99 product sold by the supplement company.
10-13-2008, 05:44 PM
10-13-2008, 05:53 PM
10-14-2008, 12:01 AM
10-14-2008, 01:15 AM
10-14-2008, 03:04 AM
Nice of you to make the effort in every thread but mine.Originally Posted by pumbertot
Yep and then go lift some weight properly.Originally Posted by pumbertot
Here's my thread on how to do it "properly". See my last two really frick'in cool posts in that thread...
Partial/Variable ROMS = Muscle Growth
10-14-2008, 09:53 AM
Dosed 500mcg last night.....got flushing (the primary feeling of pressure/tightness around neck, heated feeling, and some sweating) so I'm assuming the products were shipped as labeled. Blood pressure after injection was fine (100/75) and it continued to be on the lower-end ~2 hrs later. I then dosed regular mcgs (100 CJC/300GHRP) this morning. I was going to do a "nooner", but I think I'll save it for this evening since I have enough CJC floating around and I only shoot CJC/GHRP using 1 syringe, so I can't do just GHRP at noon. I will decrease dosages by 50% starting tomorrow, so I will then be shooting: 50mcg CJC/150mcg GHRP to see if BP and headaches disappear. If so, I will work my way up to 100/300.
10-14-2008, 10:03 AM
You two are REAL pieces of work, you know that? Come up in my log all pissin' & moanin' about how overly precise and whatnot I am. Then you excitedly click back to your overly-scientific threads, analyzing graph upon graph and study upon study.....LOL.... I wuv you two!
10-14-2008, 01:11 PM
10-14-2008, 01:15 PM
10-14-2008, 01:32 PM
10-14-2008, 04:24 PM
10-14-2008, 04:33 PM
10-14-2008, 05:02 PM
As for a log, I doubt that anyone is interested in reading the exploits of an old man with a bum back who is losing strength and size by the week!
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