New E-pharm product: URSOBOLIC !

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    So $40 for a month supply?
    Cutting all summer, cycle in September

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    yes
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    Quote Originally Posted by henryv

    It's sold out. You'll have to wait for one of the other retailers to list it. It wont be long.
    How many bottles did they get? 5? Why do they not show it OOS instead of making it invisible? That's so not cool.
    •   
       

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    Got me a bottle... This stuff sold like hotcakes...lol
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    its available on amazon now, just search ursobolic.
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    45$ for 30 days is pretty steep
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    Quote Originally Posted by Ginandtonic
    45$ for 30 days is pretty steep
    Yea. I'm waiting for the logs on this one
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    What's the percentage of extracted Ursolic acid??
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    Quote Originally Posted by Orangatang View Post
    What's the percentage of extracted Ursolic acid??
    25% extract. Not sure of the source.

    50mg active per cap.
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    Quote Originally Posted by Rushi

    25% extract. Not sure of the source.

    50mg active per cap.
    Wow. So like 200mg per cap. Then the dosing is at 6 caps a day?
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    Quote Originally Posted by Rushi View Post
    25% extract. Not sure of the source.

    50mg active per cap.
    Highly extracted holy basil???
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    Quote Originally Posted by Orangatang

    Highly extracted holy basil???
    Hehe saw that on amazon as well. Holy basil and apples have something in common it seems.
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    Is this product better with any certain type of diet or does it work good with everything?
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    Quote Originally Posted by houstontexas
    Is this product better with any certain type of diet or does it work good with everything?
    I'd say by the looks of it a cut diet. As far as keto, low carb, high protein, I have no idea as of now.
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    Quote Originally Posted by mattrag View Post
    Wow. So like 200mg per cap. Then the dosing is at 6 caps a day?
    Suggested use is 9-18 caps daily, split up 3x and taken with food/lipid.
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    Quote Originally Posted by Rushi View Post
    25% extract. Not sure of the source.

    50mg active per cap.
    When I say active here, I am referring to ursolic acid. There are other pentacyclic triterpene acids in there that may very well have similar activity.
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    Quote Originally Posted by Rushi

    Suggested use is 9-18 caps daily, split up 3x and taken with food/lipid.
    That is a pretty high dose
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    Quote Originally Posted by houstontexas View Post
    Is this product better with any certain type of diet or does it work good with everything?
    PA said he was drunk most of the summer and still leaned out so it may not matter what you eat.
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    Quote Originally Posted by houstontexas View Post
    How many bottles did they get? 5? Why do they not show it OOS instead of making it invisible? That's so not cool.
    They sold 100 in about two hours.

    Quote Originally Posted by Orangatang View Post
    Highly extracted holy basil???
    It's not goddamn holy basil.

    Quote Originally Posted by Rushi View Post
    When I say active here, I am referring to ursolic acid. There are other pentacyclic triterpene acids in there that may very well have similar activity.
    Yep. Oleanolic acid for one.

    Quote Originally Posted by houstontexas View Post
    Is this product better with any certain type of diet or does it work good with everything?
    I dunno. It may reduce the digestion of carbs if it does function as a competitive alpha-glucosidase inhibitor.
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    will NP be getting this anytime soon?
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    and UA affects leptin?
    SNS Online Representative
    Maxximal @ seriousnutritionsolutions.com

    Got Glycophase ...?


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    Quote Originally Posted by EArch View Post
    will NP be getting this anytime soon?
    I think so.

    Quote Originally Posted by MAxximal View Post
    and UA affects leptin?
    Maybe. Maybe not.
    Antus Labs
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    Quote Originally Posted by henryv View Post
    I think so.



    Maybe. Maybe not.
    wohaa so UA is like metformin
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    Quote Originally Posted by MAxximal View Post
    wohaa so UA is like metformin
    In addition to suppressing hepatic glucose production, metformin increases insulin sensitivity, enhances peripheral glucose uptake (by phosphorylating GLUT-4 enhancer factor), increases fatty acid oxidation,[89] and decreases absorption of glucose from the gastrointestinal tract. Increased peripheral utilization of glucose may be due to improved insulin binding to insulin receptors.[90]
    Those look like some of the same MOA that ursolic acid is believed to work by, yes. See this thread:
    The Potential Benefits of Ursolic Acid

    We're not making any drug claims of our product, just informing you of the research that has been done on the ingredient.
    Antus Labs
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    Quote Originally Posted by henryv View Post
    Those look like some of the same MOA that ursolic acid is believed to work by, yes. See this thread:
    The Potential Benefits of Ursolic Acid

    We're not making any drug claims of our product, just informing you of the research that has been done on the ingredient.
    Hmmm this sounds too interesting and I understand your point “of drug claims”.
    another question did you know if UA is broken and metabolized by the liver or not?
    I ask because I got some stacking options on my head

    TTA (Tetradecylthioacetic Acid))
    HCA (60% Hydroxycitric Acid)
    CLA (clarinol brand)
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    Quote Originally Posted by henryv View Post
    Those look like some of the same MOA that ursolic acid is believed to work by, yes. See this thread:
    The Potential Benefits of Ursolic Acid

    We're not making any drug claims of our product, just informing you of the research that has been done on the ingredient.
    Hmmm this sounds too interesting and I understand your point of drug claims.
    another question did you know if UA is broken and metabolized by the liver or not?
    I ask because I got some stacking options on my head

    TTA (Tetradecylthioacetic Acid))
    HCA (60% Hydroxycitric Acid)
    CLA (clarinol brand)
    SNS Online Representative
    Maxximal @ seriousnutritionsolutions.com

    Got Glycophase ...?


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    Quote Originally Posted by Ginandtonic View Post
    45$ for 30 days is pretty steep
    $45.40 plus $5.49 shipping. So $50.89 total for one month at the minimum recommended dosage I'm guessing. Yeah that is pretty steep. I hope Nutraplanet has a better price....
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    Quote Originally Posted by rip21 View Post
    PA said he was drunk most of the summer and still leaned out so it may not matter what you eat.
    Wow!, well that settles it than. I'm gettin me some Ursobolic!.
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    Quote Originally Posted by MAxximal View Post
    ...I got some stacking options on my head

    TTA (Tetradecylthioacetic Acid))
    HCA (60% Hydroxycitric Acid)
    CLA (clarinol brand)
    TTA may increase the effects, because it is a non-specific PPAR agonist, but I don't know if a) ursolic acid is only a PPAR-alpha agonist, or b) activation of PPAR-gamma contributes to the effects of TTA (this study seems to indicate that it doesn't, if I'm reading it right). Edit: though if TTA increases beta-oxidation of fatty acids [link] it may help.

    If HCA is an inhibitor of ATP-citrate lyase [link], and ursolic acid is an inhibitor of fatty acid synthase [link], then I would think the effects would be additive (in reducing the synthesis of fatty acids). Idk if that's a good thing or not.

    As for Clarinol:

    The effect of CLA consumption on fatty acid oxidation was also assessed. Compared with the control treatment, the CLA treatments did not affect changes in body weight, body composition, or blood lipids. In addition, CLA did not affect the β-oxidation rate of fatty acids or induce significant alterations in the safety markers tested. In conclusion, although no detrimental effects were caused by supplementation, these results do not confirm a role for CLA in either body weight or blood lipid regulation in humans.
    http://www.ncbi.nlm.nih.gov/pubmed/21593349

    CONCLUSIONS:

    CLA does not affect glucose metabolism or insulin sensitivity in a population of overweight or obese volunteers.
    http://www.ncbi.nlm.nih.gov/pubmed/17031391

    There are a lot of different isomers in CLA and some have the opposite effects of others.

    Bear in mind this is outside my field of knowledge, I'm just going off ten minutes of googling.
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    Quote Originally Posted by henryv View Post
    TTA may increase the effects, because it is a non-specific PPAR agonist, but I don't know if a) ursolic acid is only a PPAR-alpha agonist, or b) activation of PPAR-gamma contributes to the effects of TTA (this study seems to indicate that it doesn't, if I'm reading it right). Edit: though if TTA increases beta-oxidation of fatty acids [link] it may help.

    If HCA is an inhibitor of ATP-citrate lyase [link], and ursolic acid is an inhibitor of fatty acid synthase [link], then I would think the effects would be additive (in reducing the synthesis of fatty acids). Idk if that's a good thing or not.

    As for Clarinol:



    http://www.ncbi.nlm.nih.gov/pubmed/21593349



    http://www.ncbi.nlm.nih.gov/pubmed/17031391

    There are a lot of different isomers in CLA and some have the opposite effects of others.

    Bear in mind this is outside my field of knowledge, I'm just going off ten minutes of googling.

    For the CLA I will use Clarinol or Tonalin (used in the study).
    And this are the isomers of CLA:

    Cis-9,Trans-11
    Trans-10, Cis-12

    And for all of the above you are correct!

    When I got UA i on alpha test phase with my other goodies
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    I'm thinking of running this @ 9 caps for 12weeks. Just gotta grab 8 bottles when it hits the right store
    Or 18caps for 6weeks
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    Quote Originally Posted by ConcreteConny View Post
    I'm thinking of running this @ 9 caps for 12weeks. Just gotta grab 8 bottles when it hits the right store
    dang that is one expensive 6 weeks!

    good luck though!
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    Quote Originally Posted by ConcreteConny View Post
    I'm thinking of running this @ 9 caps for 12weeks. Just gotta grab 8 bottles when it hits the right store
    Or 18caps for 6weeks
    you buy it already?
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    Quote Originally Posted by mattrag View Post
    you buy it already?
    Haven't hit the EU/UK market yet. According to guestimates it should be available in 2 weeks over here Hopefully they will have enough in stock
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    Quote Originally Posted by ConcreteConny View Post
    Haven't hit the EU/UK market yet. According to guestimates it should be available in 2 weeks over here Hopefully they will have enough in stock
    Hehe I cant even find it on online retailers....
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    wonder why nutraplanet isnt selling it?
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    Nutra used to be my favorite source for supps. Anymore it seems they are out of nearly everthing.
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    Quote Originally Posted by Primal2 View Post
    wonder why nutraplanet isnt selling it?
    They'll be getting it in a couple of weeks.
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    Quote Originally Posted by BBB View Post
    Nutra used to be my favorite source for supps. Anymore it seems they are out of nearly everthing.
    Because they are everybody elses favorite too!
    Always open light. Its not what you open with, its what you finish with. Louie Simmons
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    hopefully we can see the price start to gravitate around 15 bucks, because at 20-22 its just plain too steep for LOWEST dosing. *fingers crossed*
  

  
 

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