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Cardiovascular disorders are currently the leading cause of mortality worldwide. Maintenance of a healthy cardiovascular system is pivotal to longevity in addition to keeping a healthy mind and body. Cordis by Animis is the most potent cardiovascular support formula currently available on the market. With the utilization of a synergistic blend of natural herbs formulated in Cordis, each ingredient potentiates the pharmacokinetic effects of the other. Making the therapeutic effect of the formula more potent than that obtained from any individual compound. Users of this powerful formula will experience a reduction in blood pressure, lipids, plaque buildup, and improved liver function.
Salviae Miltiorrhizae
Elevated levels of cholesterol and blood pressure are two major contributors of atherosclerosis and cardiovascular disease [01]. Salviae Miltiorrhizae has been used in traditional chinese medicine, for more than a millennium, for the treatment of blood disorders. Major components of salviae miltiorrhizae, include salvianolic acid & tanshinoate. Salvianolic acid B and Tanshinoate II are considered the two active component known for the management of circulatory disorders [02][03]. Salviae Miltiorrhizae extract has been shown to increase the export of total cholesterol and bile acid in the liver, while reducing LDL-cholesterol and increasing HDL-cholesterol in humans [04][05]. Tanshinoate IIA is one of the many active components responsible for lowering LDL, threw its ability to inhibit LDL oxidation [06][07][08]. Tanshinoate also acts to upregulate superoxide dismutase activity and eNOS phosphorylation, making it a powerful antioxidant and increaser of NO production [09][10]. Tanshinone IIA is a potent cardioprotective compound, that is able to regulate various transcription factors, ion channels, kinases, growth factor, inflammatory mediators, and more [11]. Acting to limit hypertrophy, improve heart function and strength by decreasing oxidative stress [12][14][13][15].
Salvianolic acid B protective therapeutic effects are due to its ability to act as a potent antioxidant/reactive oxygen species, anti-fibrotic agent, and an inhibitor of inflammation. Additionally, Salvianolic acid B is able to act as inhibitor of ACE, reducing the conversion of angiotensin I to angiotensin II and lowering blood pressure [16]. Tanshinoate IIA like Salvianolic acid B is able to indirectly reduce the production of angiotensin II. In addition Tanshinoate IIA is able to reduce the accumulation of cholesterol by macrophages, vary smooth muscle migration and proliferation. As well as reduce the ratio of thromboxane b2 to 6-keto prostaglandin f1α, leading to an improvement in our blood coagulation system [17]. As a side note Tanshinoate IIA has also been found to act as a powerful anti-cancer by its ability to trigger apoptosis through P53 activation among other mechanisms [18][19]. Additionally it has been shown to improve renal dysfunction by its interaction with angiotensin II, transforming growth factor β1 and collagen IV, as well as inducing apoptosis of hepatic stellate cells, reducing the effects of liver fibrosis, in rats [20][21]. Overall Tanshinone II is seen to be a very potent natural cardioprotective with its ability to dilate coronary arteries, lower blood pressure and lipids, protect from ischemic injury, act as a anti-inflammatory, antiplatelet, antithrombotic, antiarrhythmic, anticoagulant, and reverse myocardial hypertrophy [22][23][24][25][26].
Panax notoginseng
Ginseng is widely known for it restorative and healing properties. Panax Notoginseng has specifically been shown to have protective effects against cardiovascular disease, liver fibrosis and hepatotoxicity [27][28][29]. Primarily through the effects of its various constituents that have been shown to provide antioxidation, decreased platelet adhesion, vasomotor control and improved lipid profiles. Additionally it has been shown to enhance physical performance during endurance activity in humans [30]. This is primarily due to high levels of radical scavenging antioxidants and saponins that exhibit anti-inflammatory, vasodilating, anti-fatigue and the ability to act as a central nervous system stimulant [31][32]. Panax notoginseng may also be able to provide cardiovascular protection through various pharmacological mechanisms that improve microcirculation, regulate lipids, reducing arrhythmia, and has been shown to normalize blood pressure by restoring it to normal levels in individuals with both high and low blood pressure [33][34][35]. It has also shown to act as an antioxidant against atherogenesis [36]. For spanions of Panax Notoginseng have been found to have antihyperlipidemic and atherosclerotic effects [37][38][39][40]. These atherosclerotic effects are especially prominent when used in conjunction with Salvia Miltiorrhiza [41]. Additionally It has also been shown to be beneficial in protecting against tissue damage, have antihypertensive effects and may be a novel therapy for heart failure, as well as acting as a powerful antioxidant by its ability to significantly increase both superoxide dismutase and glutathione peroxidase activity [43][44][45][46]. By protecting cardiac muscle from ischemic and reperfusion injuries [47]. Research has also shown notoginseng to inhibit platelet aggregation and have preventive effects for thrombosis in vivo [48][49][50].
Pueraria Lobata
Pueraria Lobata has been used in conjunction with Salviae miltiorrhizae traditionally. Studies have shown that the two herbs work synergistically and additively, leading to improved vascular function in coronary patients [51][52][53]. Studies have demonstrated it to have anti-hypertension, anti-thrombosis, cholesterol lowering effects, and when used in conjunction with Salvia Miltiorrhiza is able to lower low-density lipoprotein and total cholesterol levels in human subjects [54][55][56][57][58]. Additionally, Puerinin has been shown to have protective effects against liver fibrosis, providing reduced oxidation, inflammation, of the liver, as well as protective effects against liver fibrosis and blood pressure [59][60][61][62].
Natural Borneol
Natural Borneol is utilized to increase the pharmacokinetic effects of the formula, particullary offering a significant 1.3-1.6 fold increase in effects of the saponins of notoginseng, as well as increasing the intestinal absorption and effects of the constituents of Salvia Miltiorrhiza [63][64][65]. In addition it helps improve oral bioavailability for the entire herbal formula [66].
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Salviae Miltiorrhizae
Elevated levels of cholesterol and blood pressure are two major contributors of atherosclerosis and cardiovascular disease [01]. Salviae Miltiorrhizae has been used in traditional chinese medicine, for more than a millennium, for the treatment of blood disorders. Major components of salviae miltiorrhizae, include salvianolic acid & tanshinoate. Salvianolic acid B and Tanshinoate II are considered the two active component known for the management of circulatory disorders [02][03]. Salviae Miltiorrhizae extract has been shown to increase the export of total cholesterol and bile acid in the liver, while reducing LDL-cholesterol and increasing HDL-cholesterol in humans [04][05]. Tanshinoate IIA is one of the many active components responsible for lowering LDL, threw its ability to inhibit LDL oxidation [06][07][08]. Tanshinoate also acts to upregulate superoxide dismutase activity and eNOS phosphorylation, making it a powerful antioxidant and increaser of NO production [09][10]. Tanshinone IIA is a potent cardioprotective compound, that is able to regulate various transcription factors, ion channels, kinases, growth factor, inflammatory mediators, and more [11]. Acting to limit hypertrophy, improve heart function and strength by decreasing oxidative stress [12][14][13][15].
Salvianolic acid B protective therapeutic effects are due to its ability to act as a potent antioxidant/reactive oxygen species, anti-fibrotic agent, and an inhibitor of inflammation. Additionally, Salvianolic acid B is able to act as inhibitor of ACE, reducing the conversion of angiotensin I to angiotensin II and lowering blood pressure [16]. Tanshinoate IIA like Salvianolic acid B is able to indirectly reduce the production of angiotensin II. In addition Tanshinoate IIA is able to reduce the accumulation of cholesterol by macrophages, vary smooth muscle migration and proliferation. As well as reduce the ratio of thromboxane b2 to 6-keto prostaglandin f1α, leading to an improvement in our blood coagulation system [17]. As a side note Tanshinoate IIA has also been found to act as a powerful anti-cancer by its ability to trigger apoptosis through P53 activation among other mechanisms [18][19]. Additionally it has been shown to improve renal dysfunction by its interaction with angiotensin II, transforming growth factor β1 and collagen IV, as well as inducing apoptosis of hepatic stellate cells, reducing the effects of liver fibrosis, in rats [20][21]. Overall Tanshinone II is seen to be a very potent natural cardioprotective with its ability to dilate coronary arteries, lower blood pressure and lipids, protect from ischemic injury, act as a anti-inflammatory, antiplatelet, antithrombotic, antiarrhythmic, anticoagulant, and reverse myocardial hypertrophy [22][23][24][25][26].
Panax notoginseng
Ginseng is widely known for it restorative and healing properties. Panax Notoginseng has specifically been shown to have protective effects against cardiovascular disease, liver fibrosis and hepatotoxicity [27][28][29]. Primarily through the effects of its various constituents that have been shown to provide antioxidation, decreased platelet adhesion, vasomotor control and improved lipid profiles. Additionally it has been shown to enhance physical performance during endurance activity in humans [30]. This is primarily due to high levels of radical scavenging antioxidants and saponins that exhibit anti-inflammatory, vasodilating, anti-fatigue and the ability to act as a central nervous system stimulant [31][32]. Panax notoginseng may also be able to provide cardiovascular protection through various pharmacological mechanisms that improve microcirculation, regulate lipids, reducing arrhythmia, and has been shown to normalize blood pressure by restoring it to normal levels in individuals with both high and low blood pressure [33][34][35]. It has also shown to act as an antioxidant against atherogenesis [36]. For spanions of Panax Notoginseng have been found to have antihyperlipidemic and atherosclerotic effects [37][38][39][40]. These atherosclerotic effects are especially prominent when used in conjunction with Salvia Miltiorrhiza [41]. Additionally It has also been shown to be beneficial in protecting against tissue damage, have antihypertensive effects and may be a novel therapy for heart failure, as well as acting as a powerful antioxidant by its ability to significantly increase both superoxide dismutase and glutathione peroxidase activity [43][44][45][46]. By protecting cardiac muscle from ischemic and reperfusion injuries [47]. Research has also shown notoginseng to inhibit platelet aggregation and have preventive effects for thrombosis in vivo [48][49][50].
Pueraria Lobata
Pueraria Lobata has been used in conjunction with Salviae miltiorrhizae traditionally. Studies have shown that the two herbs work synergistically and additively, leading to improved vascular function in coronary patients [51][52][53]. Studies have demonstrated it to have anti-hypertension, anti-thrombosis, cholesterol lowering effects, and when used in conjunction with Salvia Miltiorrhiza is able to lower low-density lipoprotein and total cholesterol levels in human subjects [54][55][56][57][58]. Additionally, Puerinin has been shown to have protective effects against liver fibrosis, providing reduced oxidation, inflammation, of the liver, as well as protective effects against liver fibrosis and blood pressure [59][60][61][62].
Natural Borneol
Natural Borneol is utilized to increase the pharmacokinetic effects of the formula, particullary offering a significant 1.3-1.6 fold increase in effects of the saponins of notoginseng, as well as increasing the intestinal absorption and effects of the constituents of Salvia Miltiorrhiza [63][64][65]. In addition it helps improve oral bioavailability for the entire herbal formula [66].
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