The unique ingredient I was referring too was the ASU blend, which is avocado and soybean unsaponifiables. We havent completed a technical write-up just yet, but there is some solid research below. In addition we have added tumeric/curcumin 95%, and hyaluronic acid to top it all off (and piperine).
Comparing it to chondroitin sulfate, with knee joint pain:
More...Clin Rheumatol. 2010 Jun;29(6):659-70. Epub 2010 Feb 24.
Efficacy and safety of piascledine 300 versus chondroitin sulfate in a 6 months treatment plus 2 months observation in patients with osteoarthritis of the knee.
Pavelka K, Coste P, Géher P, Krejci G.
Institute of Rheumatology, Charles University Prague, Prague, Czech Republic.
- Clin Rheumatol. 2010 Jul;29(7):819-20.
To investigate that a 6-month treatment with avocado soybean unsaponifiable (Piascledine 300 mg) once daily is as effective as with chondroitin sulfate 400 mg three times daily in femorotibial gonarthrosis, and also the carry-over effect for two more months is comparable. Patients were randomized (1:1) to the treatment groups. They received for 6 months 3 capsules chondroitin sulfate per day or one capsule of avocado soybean unsaponifiable (ASU) in a double-dummy technique. A 2-month post-treatment period followed to determine the carry-over effect. Primary efficacy criterion was the change of the WOMAC-index from study begin to end of treatment. Secondary criteria were the changes in Lequesne-index, pain on active movement and at rest, global assessment of efficacy. Three hundred sixty-four patients have been taken up into the trial. Three hundred sixty one patients were eligible for evaluation. One hundred eighty three received ASU 300 mg once daily, one hundred seventy eight chondroitin sulfate three times daily. The WOMAC-index decreased in both groups for approx. 50% to the end of therapy. During the post-treatment observation there was a further slight improvement. There was no statistical significant difference between the treatment groups during the entire observation. All other observed parameters showed the same pattern. The daily intake of rescue medication was reduced continuously. Overall efficacy has been rated excellent and good in more than 80% of the patients in both groups. Both drugs were safe and well tolerated. The first direct comparison between avocado soybean unsaponifiable 300 mg once daily and chondroitin sulfate three times daily reveiled no difference in efficacy or safety aspects between 1 capsule ASU 300 mg per day and 3 capsules chondroitin sulfate per day. It can be assumed that the once daily intake of ASU will lead to a better compliance in routine therapy.
PMID: 20179981 [PubMed - indexed for MEDLINE]
A meta analysis regarding lower pack pain relief...Ortop Traumatol Rehabil. 2003 Apr 30;5(2):248-51.Application of avocado/soybean unsaponifiable mixtures (piascledine) in treatment of patients with osteoarthritis.
Katedra i Klinika Chorób Wewnetrznych, Slaska Akademia Medyczna, Katowice.
Mixture of nonsaponifiable components of avocado and soybean oils known as piascledine is a drug applied is patients with osteoarthritis. The drug combine properties of structure modifying drug with symptom modifying drug.<br /> Piascledine was shown to enhance collagen and proteoglycan synthesis and to decrease synthesis of fibronectin by cultured in vitro chondrocytes. Moreover, the drug inhibits release and activity of metalloproteinases and proinflammatory cytokines, a key factors involved in development of osteoarthritis.<br /> Well controlled clinical trials evidenced that piascledine improves functional indices and results a decrease in pain as well as in diminished analgesic drug demand in patients with osteoarthritis. Administration of the drug within two years resulted in delayed destruction of the joints as shown in radiological evaluation. Application of piascledine is very well tolerated medication.
PMID: 18034015 [PubMed - in process]
Phytother Res. 2007 Jul;21(7):675-83.Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain.
Chrubasik JE, Roufogalis BD, Chrubasik S.
Institute of Forensic Medicine, University of Freiburg im Breisgau, Albertstr. 9 79104 Freiburg im Breisgau, Germany. email@example.com
Treatment with herbal medicines is very popular in Europe. In order to get information on the evidence of effectiveness of oral herbal medicines in the treatment of pain in the joints or lower back, OVID(MEDLINE), PUBMED and COCHRANE COLLABORATION LIBRARY were searched back to 1985 for systematic reviews. The level of evidence of effectiveness was defined as strong - at least two confirmatory studies demonstrating a clinical relevant effect, moderate - one confirmatory study with a clinical relevant effect and/or multiple exploratory studies of good quality; otherwise the evidence was insufficient or conflicting in the case of inconsistent findings. Fifteen systematic reviews were identified. The evidence of effectiveness was strong for a proprietary unsaponifiable avocado soybean fraction and Harpagophytum preparations containing > 50 mg harpagoside in the daily dosage, moderate for ginger and a proprietary rose hip and seed powder, insufficient for Boswellia serrata gum resin and other herbal preparations and inconsistent for a proprietary willow bark extract. Further rigorous studies are required to confirm the usefulness of herbal medicines in the treatment of osteoarthritic complaints and chronic low back pain in order to enable acceptance of the herbal medicines into the treatment guidelines.
Copyright 2007 John Wiley & Sons, Ltd.
PMID: 17444576 [PubMed - indexed for MEDLINE]