The test in that article has been conducted on the heart muscle and I presume you ware referring to the results in influence of calcium ion channels by higenamine and coclaurine? I have reread numerous times the chapter 5 (pp. 65-77) in book called Voltage-Gated Ion Channels as Drug Targets (ISBN 3-527-31258-7) and also found well summarized info on wiki about different types of calcium channels. It appears that L-type channels are mostly concentrated in cardiac muscle (the tissue used in the article), while in brain there are mostly P-type, Q-type and N-type of channels. Is it therefore correct to judge the possible CNS activities of Higenamine and Coclaurine in the brain, based on the test performed on L-type of channels?