- 12-06-2012, 04:44 PM
- 12-06-2012, 04:45 PM
12-06-2012, 04:50 PM
12-06-2012, 04:52 PM
12-06-2012, 05:53 PM
12-06-2012, 07:17 PM
The test in that article has been conducted on the heart muscle and I presume you ware referring to the results in influence of calcium ion channels by higenamine and coclaurine? I have reread numerous times the chapter 5 (pp. 65-77) in book called Voltage-Gated Ion Channels as Drug Targets (ISBN 3-527-31258-7) and also found well summarized info on wiki about different types of calcium channels. It appears that L-type channels are mostly concentrated in cardiac muscle (the tissue used in the article), while in brain there are mostly P-type, Q-type and N-type of channels. Is it therefore correct to judge the possible CNS activities of Higenamine and Coclaurine in the brain, based on the test performed on L-type of channels?
12-06-2012, 07:43 PM
cvpharmacology. com/cardiostimulatory/beta-receptors-Gs.gif <---(This image may help).
As I have already mentioned, neither higenamine nor colclaurine have access to the CNS, and probably do not interact directly with calcium channels.
12-07-2012, 07:30 AM
However, I cannot stop wondering that the prediction in ACD/I-Lab can be so wrong. They use predictions of LogPS (rate of brain penetration), LogPB/LogBB (extent of brain penetration) and Log(PS*fu, brain) (Brain/plasma equilibration rate) as a measure of “brain penetration sufficient for CNS activity”. There are numerous nicely writer articles about efforts on estimating accurate predictions of new compounds’ properties.
Did you have a look at this tool?
ilab.acdlabs.com/iLab2 (I use your trick )
12-07-2012, 07:40 AM
PA what led you to look for DMAA in the first place? Was it a quest to find an ephedrine alternative? Do you have an interest in finding an alternative to DMAA? If no what would it take to generate an interest in such?
Thank you for your time.
12-07-2012, 07:47 AM
12-08-2012, 02:11 PM
The X-man had been to Holland a couple of days before going to Sweden. In Holland he smoked a joint, which explains the narcotics. He also had prescriptions for his aas, which cleared him from the drug use. I think he lost a contract with a supplement company because of his arrest.Originally Posted by Patrick Arnold
Norway is more strict than Sweden, but one is allowed to use aas.
12-08-2012, 02:14 PM
12-08-2012, 04:42 PM
12-08-2012, 08:37 PM
12-09-2012, 05:42 AM
12-09-2012, 10:49 AM
and i was researching a different area when i came across a reference that mentioned dmaa. since i had never heard of it and was curious i did a literature search on the chemical and found articles that suggested it might be a decent cns stimulant
i have tried to find an alternative to dmaa. i have come across candidates, but none of them have evidence of being natural. thats the problem
Anabolicminds.com Featured Author
12-09-2012, 10:51 AM
12-09-2012, 10:52 AM
12-09-2012, 10:56 AM
12-09-2012, 12:37 PM
12-09-2012, 03:41 PM
The pity with most PEA analogs (including halostachine) is the lack of the amine protection, due to the “nakedness” on alpha position.
12-09-2012, 04:19 PM
Now I do not exactly know the laws around tryptamines, but did you researched the possibility of finding a legal and natural tryptamine with good oral bioavailability and use it as a stimulant? Do you know about Dr. James Fadiman’s work on micro dosing psychedelics? It seems that a micro dose have a good stimulant with anti-depressive properties. Now, I understand that you cannot use what Fadiman experimented with, but I suppose, that there may be a similar compound in structure and properties as of those that are already scheduled?
EDIT: Hmmm, I probably was too quick with assuming that NMT is N-Methyltryptamine, while you probably meant N-Methyltyramine? However, the question still stands, since tickling the serotonergic receptors seems to produce very noticeable stimulatory effects.
12-09-2012, 09:07 PM
12-09-2012, 09:44 PM
Sheeezus, well, most of that is waaay over my head. But what i do know is, when using DMAA and a strong coffee i can sit and read and really focus and take in what i'm reading OR i can go to the gym and do a 1 1/2 hour super-intense leg and ab workout!!!
Not many other stimulants can give me those options.
12-09-2012, 10:14 PM
EDIT: Double checked on the dose Fadiman used for the study, it was 10mcg not 25mcg.
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