- 12-05-2012, 03:04 PM
You are misunderstanding the meaning of the word profiling as I meant it. Profiling in the context I am talking about means selectively pursuing a suspect based on characteristics such as race or religion or style of clothes they wear etc. Examples would be preferentially pulling a muslim aside at an airport for secondary screening or pulling a hispanic guy in a car over and asking for his identification because you suspect he may be illegal.Anabolicminds.com Featured Author
- 12-05-2012, 03:12 PM
12-05-2012, 03:34 PM
Sweden is on other hand too much of humanistic, meaning, for example the convicts have quit a lot of rights. Therefore I am not surprised to read in newspaper that convicted pedophiles ware sending each other pictures of children over the mobile phones, since in Sweden, they are allowed to keep them.
I do not want to make this thread to much of a political debate. So to make some sort of a conclusion the two biggest negative thinks (as I see them) are: 1 the state is trying to over protect its citizens and 2 on another hand they try to preserve the humanistic rights for everybody. And this in the end creates such weird situations.
12-05-2012, 03:43 PM
12-05-2012, 04:01 PM
12-05-2012, 10:54 PM
12-06-2012, 09:18 AM
12-06-2012, 11:33 AM
So we can say, if the substance is binding to ERalpha as agonist it will extra stimulate HPTA and in case of an antagonist then it will suppress HPTA?
12-06-2012, 01:10 PM
12-06-2012, 02:46 PM
A small clarification about the incident with convicted pedophiles. I meant that they could keep the mobile phones during serving their sentence. Not that they were able to keep the pictures of which they have been convicted for, as one could understand from my previously written text. Sweden have its weird moments, but not that severely creepy.
12-06-2012, 03:01 PM
The difference between a four star prison and a four star hotel is I can leave the latter at will the former not so much. I think I will not be visiting.
12-06-2012, 03:15 PM
12-06-2012, 05:24 PM
12-06-2012, 05:31 PM
EDIT: Predictions are done in ACD/I-lab.
12-06-2012, 05:41 PM
(1) jstage. jst. go. jp/article/jphs1951/50/1/50_1_75/_pdf
12-06-2012, 05:44 PM
12-06-2012, 05:45 PM
12-06-2012, 05:50 PM
12-06-2012, 05:52 PM
12-06-2012, 06:53 PM
12-06-2012, 08:17 PM
The test in that article has been conducted on the heart muscle and I presume you ware referring to the results in influence of calcium ion channels by higenamine and coclaurine? I have reread numerous times the chapter 5 (pp. 65-77) in book called Voltage-Gated Ion Channels as Drug Targets (ISBN 3-527-31258-7) and also found well summarized info on wiki about different types of calcium channels. It appears that L-type channels are mostly concentrated in cardiac muscle (the tissue used in the article), while in brain there are mostly P-type, Q-type and N-type of channels. Is it therefore correct to judge the possible CNS activities of Higenamine and Coclaurine in the brain, based on the test performed on L-type of channels?
12-06-2012, 08:43 PM
cvpharmacology. com/cardiostimulatory/beta-receptors-Gs.gif <---(This image may help).
As I have already mentioned, neither higenamine nor colclaurine have access to the CNS, and probably do not interact directly with calcium channels.
12-07-2012, 08:30 AM
However, I cannot stop wondering that the prediction in ACD/I-Lab can be so wrong. They use predictions of LogPS (rate of brain penetration), LogPB/LogBB (extent of brain penetration) and Log(PS*fu, brain) (Brain/plasma equilibration rate) as a measure of “brain penetration sufficient for CNS activity”. There are numerous nicely writer articles about efforts on estimating accurate predictions of new compounds’ properties.
Did you have a look at this tool?
ilab.acdlabs.com/iLab2 (I use your trick )
12-07-2012, 08:40 AM
PA what led you to look for DMAA in the first place? Was it a quest to find an ephedrine alternative? Do you have an interest in finding an alternative to DMAA? If no what would it take to generate an interest in such?
Thank you for your time.
12-07-2012, 08:47 AM
12-08-2012, 03:11 PM
The X-man had been to Holland a couple of days before going to Sweden. In Holland he smoked a joint, which explains the narcotics. He also had prescriptions for his aas, which cleared him from the drug use. I think he lost a contract with a supplement company because of his arrest.Originally Posted by Patrick Arnold
Norway is more strict than Sweden, but one is allowed to use aas.
12-08-2012, 03:14 PM
12-08-2012, 05:42 PM
12-08-2012, 09:37 PM
12-09-2012, 06:42 AM
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