Curcumin

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    Curcumin


    Hey PA,
    How do you recommend dosing your Curcumin and piperine (bioperine)? Currently using LE Super Bio-Curc

    Thanks
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    Quote Originally Posted by Powercage View Post
    Hey PA,
    How do you recommend dosing your Curcumin and piperine (bioperine)? Currently using LE Super Bio-Curc

    Thanks
    i havent taken it in a while. when i did, i followed the popular protocols.

    its a promising compound, however i only bother to take so many pills a day and lately i have cut curcumin out of the mix
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    I guess I'll click that link since you're a female
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    Quote Originally Posted by Powercage
    Hey PA,
    How do you recommend dosing your Curcumin and piperine (bioperine)? Currently using LE Super Bio-Curc

    Thanks
    Just buy some turmeric at the local whole foods store and add it to your food, that way you don't have the additives from caps.
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    Quote Originally Posted by 0071982WC View Post
    Just buy some turmeric at the local whole foods store and add it to your food, that way you don't have the additives from caps.
    we know how dangerous gelatin is....
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    I like everything about curcumin except the fact it is very strongly activates AMPK, which shuts off mTOR in skeletal muscle. Although I am interested in what pat thinks of this.

    A number of good ingredients have shown to increase AMPK a good amount. Berberine for example does, and also has data showing it caused mild muscle atrophy which could ahve been caused from the fact it inhibited mTOR via AMPK activation.

    The study said the atrophy was caused by atrogin-1 stimulation. AMPK activation causes atrogin-1 stimulation.

    So lots of negatives regarding muscle growth and AMPK activation
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    Quote Originally Posted by nattydisaster View Post
    I like everything about curcumin except the fact it is very strongly activates AMPK, which shuts off mTOR in skeletal muscle. Although I am interested in what pat thinks of this.

    A number of good ingredients have shown to increase AMPK a good amount. Berberine for example does, and also has data showing it caused mild muscle atrophy which could ahve been caused from the fact it inhibited mTOR via AMPK activation.

    The study said the atrophy was caused by atrogin-1 stimulation. AMPK activation causes atrogin-1 stimulation
    There are a couple different AMPK isoforms. Which if i remember correctly are tissue specific. Might be worth looking into.
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    Quote Originally Posted by nattydisaster View Post
    I like everything about curcumin except the fact it is very strongly activates AMPK, which shuts off mTOR in skeletal muscle. Although I am interested in what pat thinks of this.

    A number of good ingredients have shown to increase AMPK a good amount. Berberine for example does, and also has data showing it caused mild muscle atrophy which could ahve been caused from the fact it inhibited mTOR via AMPK activation.

    The study said the atrophy was caused by atrogin-1 stimulation. AMPK activation causes atrogin-1 stimulation

    ursolic acid reduces atrogin-1 expression

    "As discussed above, atrogin-1 and MuRF1 are transcriptionallyupregulated by atrophy-inducing stresses (Sacheck et al.,
    2007; and Figure 1B), and they are required for muscle atrophy
    (Bodine et al., 2001a). Moreover, in our studies of fasted mice,
    we found that ursolic acid reduced atrogin-1 and MuRF1 mRNAs
    (Figure 2H). Consistent with that finding, the arrays indicated
    that dietary ursolic acid reduced atrogin-1 mRNA, which was
    the most highly repressed mRNA measured on the array"

    i understand the ampk - mTOR seesaw issue. but i dunno if its something that you should base everything on when it comes to compounds like curcumin with such a wide array of effects
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    That is a great mechanism by UA to increase muscle hypertrophy and/or be anti-catabolic then.

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    Quote Originally Posted by Patrick Arnold

    we know how dangerous gelatin is....
    Magnesium sterate....
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    Quote Originally Posted by 0071982WC View Post
    Magnesium sterate....
    magnesium is a mineral most athletes are deficient in

    stearic acid is one of the most common dietary fatty acids found in food

    but those are moot points anyone because the amount of mag stearate used for excipient purposes is trivial

    try again
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    No point, I obviously cannot debate on your level of intellect ......
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    Quote Originally Posted by 0071982WC View Post
    No point, I obviously cannot debate on your level of intellect ......
    its not really about intellect, its about knowledge. i am really kinda dumb, i just know alot of stuph


    i was that kid that sat in the corner of homeroom and rocked back and forth
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    Quote Originally Posted by Patrick Arnold

    its not really about intellect, its about knowledge. i am really kinda dumb, i just know alot of stuph
    Lol
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    Quote Originally Posted by Patrick Arnold View Post
    we know how dangerous gelatin is....
    are you being sarcastic?
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    Quote Originally Posted by Patrick Arnold

    magnesium is a mineral most athletes are deficient in

    stearic acid is one of the most common dietary fatty acids found in food

    but those are moot points anyone because the amount of mag stearate used for excipient purposes is trivial

    try again
    Just playing Devils advocate here. Titanium dioxide could possibly raise concern, however as with mag stearate quantities used in caps are most likely trivial. However, with the amount of caps some people consume who knows. Particularly if they were ultrafine particles.
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    Quote Originally Posted by Vegking View Post
    are you being sarcastic?

    is that ok? is sarcasm ok to do on this board? because apparently alot of people here find it very upsetting.
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    Quote Originally Posted by broons View Post
    Just playing Devils advocate here. Titanium dioxide could possibly raise concern, however as with mag stearate quantities used in caps are most likely trivial. However, with the amount of caps some people consume who knows. Particularly if they were ultrafine particles.
    are you talking about mag or tit?
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    Tit dioxide. As I said, just playing devils advocate
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    Quote Originally Posted by broons View Post
    Tit dioxide. As I said, just playing devils advocate

    well when its used its used in very small amounts. Its considered to be non-toxic at that dose. of course on the internetz you can always find someone who is crying about the toxicity of whatever

    titanium is found in the soil everywhere i believe. you probably ingest it all the time when eating fruits and veggies
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    Quote Originally Posted by Patrick Arnold

    well when its used its used in very small amounts. Its considered to be non-toxic at that dose. of course on the internetz you can always find someone who is crying about the toxicity of whatever

    titanium is found in the soil everywhere i believe. you probably ingest it all the time when eating fruits and veggies
    Yes, I would agree with you. I brought it up for the sake of discussion only. The IARC has classified it as "possibly carcinogenic to humans" due to some rat studies and industrial observations but the amounts involved are exponentially larger than what's in a few caps.

    Anyways, this thread was about curcumin I apologize for derailing it a little bit there.
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    Quote Originally Posted by Patrick Arnold View Post
    is that ok? is sarcasm ok to do on this board? because apparently alot of people here find it very upsetting.
    of course it is okay. your forum anyway. I just didn't know, I'm a little slow on the uptake sometimes. thanks.
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    Turmeric is a good seasoning but damn it's terrible for your breath.

    Caps with Bioperine is the way to go I suppose.
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    Quote Originally Posted by Powercage View Post
    Hey PA,
    How do you recommend dosing your Curcumin and piperine (bioperine)? Currently using LE Super Bio-Curc

    Thanks
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    Curcumin from what I gather is an inhibitor of tgf-b. There is a thread on the site which makes a connection between ursolic acid, tgf-b and myostatin. Maybe this is why there are studies which have shown curcumin and muscle tissue regeneration.
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    Quote Originally Posted by Patrick Arnold View Post
    its not really about intellect, its about knowledge. i am really kinda dumb, i just know alot of stuph


    i was that kid that sat in the corner of homeroom and rocked back and forth
    Well I guess that makes 2 of us. And it takes more than 2 to tango... or something like that?
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    What about this form of curcumin?

    http://www.longvida.com/index.php

    AOR uses it and supposedly it is much better.
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    Quote Originally Posted by PuZo View Post
    What about this form of curcumin?

    http://www.longvida.com/index.php

    AOR uses it and supposedly it is much better.
    AOR is all I needed to see to validate the legitimacy of a quality company. Thanks for the link as well!
    Last edited by Force of Green; 02-20-2012 at 03:03 PM. Reason: syntax error
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    Quote Originally Posted by PuZo View Post
    What about this form of curcumin?

    http://www.longvida.com/index.php

    AOR uses it and supposedly it is much better.

    if what they say is true then it looks good.

    what more can i say?
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    what is AOR
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    Quote Originally Posted by Patrick Arnold View Post
    what is AOR
    A brand
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    Quote Originally Posted by Patrick Arnold View Post
    what is AOR
    You've never heard of Ortho Core?
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    Quote Originally Posted by PuZo View Post
    You've never heard of Ortho Core?

    nope. is this some canadian thing?
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    i dont pay attention to other supplement companies or their products anymore. maybe thats good, maybe thats bad. 95% of the stuff out there is crap so i figure i save alot of frustration by just minding my own bizness
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    Quote Originally Posted by Patrick Arnold View Post
    i dont pay attention to other supplement companies or their products anymore. maybe thats good, maybe thats bad. 95% of the stuff out there is crap so i figure i save alot of frustration by just minding my own bizness
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    i will just stick with my generic store bought vitamin and mineral. if i want 1.8mg of trans-resveratrol I'll eat a grape
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    Quote Originally Posted by Patrick Arnold View Post
    i will just stick with my generic store bought vitamin and mineral. if i want 1.8mg of trans-resveratrol I'll eat a grape
    I'd be more concerned if you bought a multi solely for the trans-resveratrol...
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