Zappetite FAQ

[dito]

Zappetite



What is Zappetite?
Zappetite is a formula that is designed to aid you in your weight-loss endeavors. Quite often the toughest part of a diet is staying on it. Cravings begin to kick in, the tummy is growling, and you're grumpy from days of being low-carb and you give into temptation by eating an entire pie, 3 dozen cookies, and a small child. Zappetite is designed to curb appetite, control cravings, and give you a feeling of fullness from even the tiniest of meals. In addition to being able to help you maintain willpower, it can also aid in fat-loss. This makes it a great addition to any weight-loss supplement regiment.
What is in Zappetite?
OEA (Oleoylethanolamide)
Hoodia Gordonii (aerial parts) Test positive for P57!
Slimondslim™ (Jojoba seed standardized for 15% Simmondsin)
LotuSlim™ Lotus Leaf extract (Standardized for 20% flavones and alkaloids)
Evodia rutaecarpa (fruit) (Standardized for 20% Evodiamine)
Angelica Dhaurica (root) (Standardized for 5% imperatorin)
Sceletium tortuosum (leaves)

That's a lot of big words....what do all of them mean?

Oleoylethanolamide
Oleyoethanolamide is a naturally occuring amide of oleic acid and ethanolamine,synthesized in the human body primarily by upper part of the small intestine especially when the meal is rich with fats.


It belongs in a family of naturally occurring fatty acid ethanolamides(FAEs), present in both animal and plant organisms[1,2]. It received little attention till it was found that a member of the same family, anandamide, served as an endogenous ligand for cannabinoid receptors(3,4) the G-protein-coupled receptors targeted by Ä9-tetrahydrocannabinol in marijuana [5, 6].


It was found that in the duodenum and jejunum of rats and mice, OEA levels change in response to nutrient status- they are lower in food-deprived than free-feeding animals, and return to normal values upon refeeding [7]. This changes happen in the upper part of the small intestine-the part most associated with food intake and feeding behaviour[8].OEA levels in the rodent small intestine also display diurnal fluctuations. They are higher during the daytime, when animals are satiated, and lower during the night,when they are awake and actively feeding [9]. These findings led researchers conclude that OEA will affect appetite and feeing behaviour. Indeed, studies in mice have shown OEA to suppress appetite in a time and dosage dependent way[10-13]


Apart from it’s appetite suppressing abilities, OEA is also a potent PPAR-á agonist. PPAR-á receptors are a class of nuclear receptors that are also the target for antihyperlipidemic drugs whose stimulation induces increased fatty acid catabolism, lower blood lipid levels and lowered body weight gain[14,15]. In fact, OEA is such a powerful PPAR-á agonist that it’s agonistic action exceeds that of many other PPAR-á agonists[16]. Indeed, apart from it’s antiorexiant actions, OEA has reduced weight when administered chronically to both obese and lean mice.[17] All current data suggests OEA as a very potent compound for the management of appetite and treatment of obesity[16]

Hoodia Gordonii
Hoodia Gordonii is a cactus-like plant from South Africa, from the large Milkweed family. Reports and interviews from South Africa natives suggested that the plant could assuage both the feeling and “pangs” of hunger that occurred during the long treks.[18] Animal studies compromised on extracts from various parts of the plant have shown that Hoodia Gordonii extract can reduce appetite, balance blood sugar levels and promote weight loss, even in overfed animals[19], Animal safety studies have not shown any deleterious side effects independent of the weight loss itself. The putative active component in these sap extracts is a trirhabinoside, known as P57AS3. ZAPPED is currently the only supplement on the market containing Hoodia Gordonii extract that has been tested positive for P57. The mechanism of action of P57 was studied in rats[19]. It was found that P57 increases ATP concentration in the hypothalamus(the part of the brain that among other thing modulates feeding, body temperature, sleep and hormonal release) by 50-150%. It has been found that following long time hypo caloric diets, hypothalamic ATP levels drop by 40-60%, which may very well lead to decreased hormonal production, sleep problems, tiredness e.t.c. Summing up current evidence, apart from the appetite suppression, P57 is very important from combating the side effects following caloric-restricted diets.
click here to see lab results on Thermolife's Hoodia

Slimondslim™
The jojoba plant (Simmondsia chinensis) is a shrub cultivated in arid and semiarid regions for its oil containing nuts. When the leftovers of oil production (jojoba meal) were supplemented to animal food, a profound reduction in food intake was observed. It was demonstrated that simmondsin, a glycoside, was responsible for the appetite-reducing effects of jojoba meal [20]. No major toxic effects have been noted after long-term administration of low doses of simmondsin inducing a sustained food intake and growth reduction in growing rats [21,22]. The food intake-reducing activity seems to be at least in a great part mediated via the vagal nerve since vagotomy significantly reduces the simmondsin-induced food intake inhibition [23]. Further studies on rats have shown the anorectic effects to be dose-dependent, improve with continued simmondsin administration, are greater for overfed rats compared to underfed rats and can also induce taste aversion to craved foods like a saccharin solution[24]. Simmondsin is powerful agent to reduce craving for food.

 

[dito]

LotuSlim™
The Lotus Leaf (Nelumbo nucifera)is a traditional herb, primarily found in India, used for it’s refrigerant, cardiotonic, astringent and liver protecting actions. Studies have also demonstrated that it possesses potent antioxidant,[25], anti-hyperlipidemic[26] and antiviral[27] actions. A study on rats has demonstrated that Lotus Leaf can lower heightened glucose levels, improve glucose tolerance, potentiate insulin activity (both endogenous and exogenous) and reduce glucose absorption [28].

Evodia rutaecarpa
Evodiamine, isolated from the dry unripened fruit of Evodia rutaecarpa Bentham, is used for it’s analgesic,, antiemetic, astringent, and antihypertensive effects in traditional Chinese Herbalism. [29]. Evodiamine also possesses antioxidant and anti-inflammatory activities[30] as well as antianoxic action on oxygen-deprived brain cells[31].


The exact mechanisms of action of Evodiamine are many and still under research. In a study in rats[32], evodiamine demonstrated potent activity as a Cholecystokinine(CCK) agonist. The functions of cholecystokinin (CCK) include stimulation of pancreatic enzyme secretion and inhibition of gastric emptying[33]as well as suppression of food intake [33]. Thus, evodiamine can extend the satiating effect of food by slowing food emptying and reduce overall food intake. Evodiamine also exerts it’s fat loss actions through stimulation of the vallinoid receptors, in the same way as capsaicin.[34] In a study performed on rats , Evodiamine would induce heat loss and heat production at the same time and dissipate food energy, preventing the accumulation of perivisceral fat and the body weight increase.[34]

Angelica Dhaurica
Angelica dahurica Bentham et Hooker (Umbelliferae)is a perennial herb distributed in the whole area of Korea, and its root has been most frequently prescribed as a sedative and an analgesic in Chinese medicine[35]. Angelica species have been traditionally used from the middle ages for various ailments. From various phytochemical studies, it has now been established that the majority of Angelica species contain quite high amounts of biologically active coumarins, predominantly simple- and furano- coumarins like umbelliprenin [36], bergapten, [37] imperatorin [38], isoimperatorin [39], byakangelicin [40], etc., and other active components. Angelica Dhaurica’s furanocumarines imperatorin ,isoimperatorin , and oxypeucedanin are proven to have potent acetylcholynesterase inhibitory activity. Acetylcholynesterase is the enzyme that breaks up the neurotransmitter acetylcholine into acetic acid and choline. Among other things, acetylcholine dilates and relaxes blood vessels, which allows easier removal of fatty acids from adipose cells and also increases c-GMP concentration in fat cells by up to 350% in vitro.[41] Furanocoumarins such as oxypeucedanin hydrate, bergapten, xanthotoxin, imperatorin and phellopterin can also activate adrenalin-induced lipolysis. Imperatorin, oxypeucedanin hydrate and phellopterin also activate ACTH-induced lipolysis. Byakangelicin, neobyakangelicin and isopimpinellin strongly inhibite insulin-stimulated lipogenesis.[42]

Sceletium tortuosum

Sceletium Tortuosum Herba (kougoed) is a traditional herb found mainly in the Western and Eastern Cape provinces, from
Namaqualand to Montagu. Sceletium species have been shown to contain at least 9 indole alkaloids, belonging to one of three structural types. In S. tortuosum (1-1.5% alkaloids) mesembrine appears to be most abundant (0.3% and 0.86% have been reported, respectively, in leaf and stem). Mesembrenone and 4’-O-demethylmesembrenol are also present. Tortuosamine, also isolated from S. tortuosum, represents a second structural type in which the pyrrole ring is opened. Alkaloid levels appear to fluctuate seasonally and may be highest in late spring/early summer; this is the time when plants are traditionally gathered and prepared for use [44]


There are many reports in the literature concerning the activity and use of 'kougoed' by the indigenous peoples.' One of the most reputed “side effects” (considered negative by the indigenous people) was loss of appetite [45]. Other traditional uses include use for relief of stomach and tooth pains, sedative, mood enhancement and thirst/hunger suppression. [46]

Cliff Notes:
Oleoylethanolamide (OEA) – levels of this amine are higher after eating, so raising the level through supplementation makes you brain think that you just ate.
Hoodia Gordonii – has been shown to raise ATP levels in the hypothalamus, which not only fights away hunger, but also fatigue and sleeping problems that are often accompanied by dieting.
Slimondslim – reduces craving for food.
LotuSlim – keeps insulin under control
Evodia rutaecarpa – slows digestion and has thermogenic properties
Angelica Dhaurica – increases lipolysis and decreases lipogenesis.
Sceletium tortuosum – decreases appetite and enhances mood

So what makes Zappetite so special?
Many 'appetite decreasers' only work through one method. Zappetite works in many different ways to keep you on track.

Does this supplement replace will power?
No. But it does help for those who are easily tempted by yummy food. Using Zappetite will help you to keep from having “cheat” meals.
But aren't cheat meals good? Aren't they supposed to increase your metabolism?
Is taking a nap during a marathon good? Cheat meals are only beneficial if it helps to keep you from going crazy from cravings. Zappetite can replace that cheat meal by helping you to stay on track without all of the excess calories. Carb ups can be good for a diet (depending on the diet and the person, of course), but that is completely different than a cheat meal
I have good will power. Will Zappetite help me?
Even for those of us who are able to resist temptation, Zappetite can still be useful but decreasing hunger pains, helping to keep portion sizes under control, and generally make the diet more pleasant. Also, Zappetite can increase fat-loss, which is always helpful
Can Zappetite be added to other fat-loss stacks?
Yes! Zappetite stacks well with almost any fat-loss supplement on the market. A great fat-loss stack with be Zappetite, Dicana, and Stizm. Dicana increases metabolism and is anti-catabolic, while Zappetite and Stizm team up to decrease appetite and improve energy. [/shameless plug]. Zappetite also stacks well with other non-Thermolife supplements.
Should Zappetite be taken with a meal or on an empty stomach?
To get best results, take two caps twice daily in between meals with a glass of water.
Will Zappetite give you digestive problems like some other appetite control supplements?
No. Some other supplements use high amounts of fiber to keep you full, but not Zappetite.

 

[dito]

References
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Bachur N. R., Masek K., Melmon K. L. and Udenfriend S. (1965) Fatty acid amides of ethanolamine in mammalian tissues.J. Biol. Chem. 240: 1019–1024
Devane W. A., Hanus L., Breuer A., Pertwee R. G., Stevenson L A., Griffin G. et al. (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258:1946–1949
Di Marzo V., Fontana A., Cadas H., Schinelli S., Cimino G., Schwartz J. C. et al. (1994) Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 372: 686–691
Matsuda L. A., Lolait S. J., Brownstein M. J., Young A. C. and Bonner T. I. (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561–564
Munro S., Thomas K. L. and Abu-Shaar M. (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature 365: 61–65
Rodríguez de Fonseca F., Navarro M., Gómez R., Escuredo L., Nava F., Fu J. et al. (2001) An anorexic lipid mediator regulated by feeding. Nature 414: 209–212
Ritter R. C. (2004) Gastrointestinal mechanisms of satiation forfood. Physiol. Behav. 81: 249–273
Fu J., Gaetani S., Oveisi F., Lo Verme J., Serrano A., Rodriguez de Fonseca F. et al. (2003) Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425: 90–93
Fu J., Gaetani S., Oveisi F., Lo Verme J., Serrano A., Rodriguez de Fonseca F. et al. (2003) Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425: 90–93
Oveisi F., Gaetani S., Eng K. T. and Piomelli D. (2004) Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration. Pharmacol. Res. 49: 461–466
Nielsen M. J., Petersen G., Astrup A. and Hansen H. S. (2004) Food intake is inhibited by oral oleoylethanolamide. J. Lipid. Res. 45: 1027–1029
Kay B. M. and Ritter R. C. (2004) Oleoylethanolamide induces rapid reduction of short-term food intake in intact and vagotomized rats. Program No. 427.12, Society for Neuroscience, Washington, DC, online
Berger J. and Moller D. E. (2002) The mechanisms of action of PPARs. Annu. Rev. Med. 53: 409–435
Willson T. M., Brown P. J., Sternbach D. D. and Henke B. R. (2000) The PPARs: from orphan receptors to drug discovery. J.Med. Chem. 43: 527–550
Regulation of food intake by oleoylethanolamide J. LoVermea, S. Gaetania,c, J. Fua, F. Oveisia, K. Burtona and D. Piomellia,b,* a Department of Pharmacology, University of California, Irvine, California 92697-4260 (USA),Fax: +1 949 824 6305
Guzmán M., Lo Verme J., Fu J., Oveisi F., Blazquez C. andPiomelli D. (2004) Oleoylethanolamide stimulates lipolysisby activating the nuclear receptor peroxisome proliferatoractivated receptor alpha (PPAR-alpha). J. Biol. Chem. 279: 27849–27854
P. Bruyns, A revision of hoodia and lavrania (Asclepidaceae-Stapeliaeae Botanische Jahrbucher:fuer), Syst. Pflanzenges. Pflanzengeogr. 115 (1993) 145–270.
Brain Research 1020 (2004) 1 –11 Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside David B. MacLean*, Lu-Guang Luo
Booth AN, Elliger CA, Wain Jr AC. Isolation of a toxic factor from jojoba meal. Life Sci 1974;15:1115– 20.
Cokelaere M, Cauwelier B, Cokelaere K, Flo G, Houache N, Lievens S, et al. Hematological and pathological effects of 0.25% purified simmondsin in growing rats. Ind Crops Prod 2000;12:165– 71.
Cokelaere M, Daenens P, Decuypere E, Flo G, Ku¨hn E, Van Boven M, et al. Reproductive performance of rats treated with defatted jojoba meal or simmondsin before or during gestation. Food Agric Toxicol 1998;36:13– 9.
Swank M, Sweatt J. Increased histone acetyltransferase and lysine acetyltransferase activity and biphasic activation of the ERK/RSK cascade in insular cortex during novel taste learning. J Neurosci 2001; 21(10):3383– 91.
Simmondsin: effects on meal patterns and choice behavior in rats Sylvia Lievensa, Gerda Floa, Eddy Decuypereb, Maurits Van Bovenc, Marnix Cokelaerea,*
Antioxidant Activity of Methanol Extract of the Lotus Leaf (Nelumbo nucifera Gertn.) Ming-Jiuan Wu, Lisu Wang and Ching-Yi Weng Institute of Biotechnology, Chia-Nan University of Pharmacy and Science
Journal of Ethnopharmacology 46 (1995) 125-129 Short communication Traditional Chinese medicine in treatment of hyperlipidaemia Birgitte la Cour *a, Per MOlgaard a, Zhao Yi baDepartment of Pharmacognosy, 2 Universitetsparken, 2100 Copenhagen, Denmark bGuangxi College of Traditional Chinese Medicine. 21 Ming Xiu Road, Nanning, 530001 Guangxi, P.R China
Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure–activity correlations with related alkaloids Yoshiki Kashiwada,a,* Akihiro Aoshima,a Yasumasa Ikeshiro,a Yuh-Pan Chen,b Hiroshi Furukawa,c Masataka Itoigawa,d Toshihiro Fujioka,e Kunihide Mihashi,e L. Mark Cosentino,f Susan L. Morris-Natschkeg and Kuo-Hsiung Leeg,* aFaculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata 950-2081, Japan
Journal of Ethnopharmacology 58 (1997) 207 213 Effect of Nelumbo nucifera rhizome extract on blood sugar level in rats Pulok K. Mukherjee, Kakali Saha, M. Pal, B.P. Saha * Department of Pharmaceutical Technology, Faculty of Engineerb~g and Technology, Jadavpur b~iversity, Calcutta 700 032, India
Tang, W., Eisenbrand, G., 1992. Evodia rutaecarpa (Juss.) Benth. In: Tang, W., Eisenbrand, G. (Eds.), Chinese Drugs of Plant Origin. Springer Verlag, New York, pp. 509–514.
Chiou, W.F., Sung, Y.J., Liao, J.F., Shum, A.Y., Chen, C.F., 1997. Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages. J. Nat. Prod. 60, 708– 711.
Journal of Ethnopharmacology, 27 0989) 185- 192 Elsevier Scientific Publishers Ireland Ltd.185 ANTIANOXIC ACTION OF EVODIAMINE, AN ALKALOID IN EVODIA RUTAECARPA FRUIT JOHJI YAMAHARA, TOSHIMASA YAMADA, TETSUYA KITANI, YOSHIKAZU NAITOH and HAJIME FUJIMURA
Effects of evodiamine on gastrointestinal motility in male rats Chiu-Lung Wua, Chen-Road Hungb, Full-Young Changc, Lie-Chwen Lind, K.-Y. Francis Paue, Paulus S. Wanga,*
(Debas et al., 1975; Jin et al., 1994),
Kobayashi Y, Nakano Y, Kizaki M, Hoshikuma K, Yokoo Y, Kamiya T. Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. Planta Med. 2001 Oct;67(7):628-33. PMID: 11582540 [PubMed - indexed for MEDLINE]
(Soka, 1985).
Kim, D. K.; Lim, J. P.; Yang, J. H.; Eom, D. O.; Eun, J. S.; Leem, K. H. Archives of Pharmacal Research, 2002, 25, 856.
Kang, S. Y.; Lee, K. Y.; Sung, S. H.; Park, M. J.; Kim, Y. C.Journal of Natural Products, 2001, 64, 683.
Chen, Y. F.; Tsai, H. Y.; Wu, T. S. Planta Medica, 1995, 61, 2.
Inamori, Y.; Baba, K.; Tsujibo, H.; Taniguchi, M.; Nakata, K.;, Kozawa, M. Chemical and Pharmaceutical Bulletin, 1991,39, 1604.
Yan, T. Y.; Hou, A. C.; Sun, B. T. Zhong Xi Yi Jie He Za Zhi., 1987, 7, 161.
Guanosine 3':5'-Cyclic Monophosphate and the Action of Insulin and Acetylcholine Gennaro Illiano, Guy P. E. Tell, Marvin I. Siegel, and Pedro Cuatrecasas
Effects of various coumarins from roots of Angelica dahuria on actions of adrenaline, ACTH and insulin in fat cells. Kimura Y. et al. Journal of Medicinal Plant Research 45: 183-187, 1982.
Coumarins and antiplatelet aggregation constituents from Formosan Peucidanum japonicum. Chen IS. et al. Phytochemistry 41: 525-530, 1996.
Smith, M.T., Field, C.R., Crouch, N.R. and Hirst, M. (1998). The distribution of mesembrine alkaloids in selected taxa of the Mesembryanthemaceae and their modification in the Sceletium derived “kougoed”. Pharmaceutical Biology 36(3): 173-179 and refs. therein.
(Marloth, 1913)
http://www.plantzafrica.com/medmonog...scelettort.pdf[/left]
source: Welcome to THERMOLIFE! sports nutrition, dietary supplements, body building, thermogenics
__________________

 

[FitnFirm]

Dito,

Will you read all those studies for me and fill me in :toofunny:


Im cutting and I need someone to slap me when ever I feel like eating something bad, Do you know anyone who can fill that job? :lol:

 

[Bootysweat]

Dito,

Will you read all those studies for me and fill me in :toofunny:


Im cutting and I need someone to slap me when ever I feel like eating something bad, Do you know anyone who can fill that job? :lol:

I'll do it!!! :twisted:

 

[Jayhawkk]

Hell no I have dibs! I needed a test subject for my cherry flavored butt lotion. Just a scientific study on the hormonal effects of repeated smacking while lubricated with aforementioned lotion.

 

[FitnFirm]

I'll do it!!! :twisted:

LOL, Fiesty today huh Booty Butt Jay is begging me too

Decisions, decisions!!!!!!!!!!!!!!:icon_lol:

 

[dvsness]

Hell no I have dibs! I needed a test subject for my cherry flavored butt lotion. Just a scientific study on the hormonal effects of repeated smacking while lubricated with aforementioned lotion.

lmfao

:whip: