SR-9009 increases testosterone from Leydig cells Really ?

[Oliver Kween]

Hello all, I

just discovered this study. Unless you have already visited it. But this surprised me, especially about SR9009, because of its half life and bioavailability. I had put it away a bit. Maybe if this study is close to the truth. Maybe SR could be integrated with higher PCT (Nolva, enclo...).
Or a light maintenance PCT (Supplements Boost test) excluding heavy cycle as with OSta for example or Lgd4

What do you think ?

SR9009 STUD


I hope you are all well!

 

[PoSiTiVeFLoW]

Hello all, I

just discovered this study. Unless you have already visited it. But this surprised me, especially about SR9009, because of its half life and bioavailability. I had put it away a bit. Maybe if this study is close to the truth. Maybe SR could be integrated with higher PCT (Nolva, enclo...).
Or a light maintenance PCT (Supplements Boost test) excluding heavy cycle as with OSta for example or Lgd4

What do you think ?

SR9009 STUD


I hope you are all well!

Alright just checked that gonna pull the trigger on some SR9009. I ran it before and really liked it but some folks on here claimed it was not bioavailable...

 

[Jeremyk1]

Well this is well above my pay grade. Should at minimum be very interesting. This was done in a cell line as far as I can tell, so not necessarily applicable to humans. Seems to help boost gene expression of something that will increase enzymes that promote testosterone synthesis. Not sure you’d see a huge boost, but yeah in a PCT scenario, it’s worth a shot. I’ve never dug into SR9009 before as I had heard it was more for endurance, so I can’t tell you anything else.

 

[Oliver Kween]

Thank you !

Yes I suppose the same thinks , it is sensibly possible. because the SR (poor ) bioavailability will make a little difference.

@PoSiTiVeFLoW Interesting what you say. I tried SR but combined with Cardarine. There was a lot of difference during the endurance. I was able to do more than usual without getting tired. With liquid on SR and capsule on Cadrarine. 10g + 20g. All combined with Carnosine (it's not a sarm lol https://www.verywellhealth.com/the-benefits-of-carnosine-89430). And Creatine.

Just as I hadn't used it since; I will try to redo this pile but without cardarine for my training in Grappling. And I'll note the difference as I go.

Too, Later I will try to do a T-up cycle with SR in a booster-t stack. and see what gives.

More on Carnosine and muscles,

Agriculture | Free Full-Text | Improved Satellite Cell Proliferation Induced by L-Carnosine Benefits Muscle Growth of Pigs in Part through Activation of the Akt/mTOR/S6K Signaling Pathway (mdpi.com)

 

[Jeremyk1]

I would be highly interested in people doing bloodwork with this stuff. Would be fun to see if this pans out.

 

[WesleyInman]

Injectable and topical sr9009 is amazing.

I've talked about it for years. As a fat loss agents the INJ is amazing.

I had topical version years back. We sold a musclegelz version of it and the endurance it gave was outstanding. Combine w cardarine for EPO style endurance.

 

[Smont]

Alright just checked that gonna pull the trigger on some SR9009. I ran it before and really liked it but some folks on here claimed it was not bioavailable...

The oral bioavailbility thing isint a claim. All you gotta do is check the research. Bio is like 2% or something like that. Mike Arnold had posted about this before I believe and I think that was what got me reading into it. You need like 150mg oral to equal a 3mg injectable equivalent. I did try the oral when it first hit the market and I didn't get anything out of it. Now if you say you did I cannot argue with your personal results. But all the research shows bio availability is very poor. I can pull up the stuff later today if anyone wants to read about it.

Still, with all that said this whole topic is extremely interesting and I never had seen this before

 

[Smont]

Injectable and topical sr9009 is amazing.

I've talked about it for years. As a fat loss agents the INJ is amazing.

I had topical version years back. We sold a musclegelz version of it and the endurance it gave was outstanding. Combine w cardarine for EPO style endurance.

November/December last year I was using 9mg injectable Sr and 10 to 20mg cardarine while I was training for boxing and it was without a doubt the leanest and best endurance I had in over 15 years. Now obviously the training I was doing was a big part of it but during the time I was on those 2 things my 1 hour workouts with 4 to 6 rounds of heavy bag and mits turned into 2hr workouts and 8 to 10 rounds on the heavy bag, 3 to 4 round sparing sessions and I still would do some weight training after those workouts.

I definitely lost some muscle and strength but I also cut 30lbs in the process and my bf wasn't very high to begin with.

 

[Oliver Kween]

The oral bioavailbility thing isint a claim. All you gotta do is check the research. Bio is like 2% or something like that. Mike Arnold had posted about this before I believe and I think that was what got me reading into it. You need like 150mg oral to equal a 3mg injectable equivalent. I did try the oral when it first hit the market and I didn't get anything out of it. Now if you say you did I cannot argue with your personal results. But all the research shows bio availability is very poor. I can pull up the stuff later today if anyone wants to read about it.

Still, with all that said this whole topic is extremely interesting and I never had seen this before

swing the sauce @Smont, it's one more thing to learn.

You are correct, SR is 2-3% in bioavailability.

Sr was my 1st "not really"sarms Oral I used. for a beginner (newbe lol), since, I found its usefulness. It was possible for a new substance for me his effects were appreciated from moment to moment over a day, even for a short Biodisponibility. Then when I learned later that it was only 2 or 3%. I spread the dose over a day morning and PM (1mlx 2 ). I specify that as beginners the effects were there.

IIt was then that I added Cardarine and it made large a difference. (@WesleyInman )
)

On the other hand, at the beginning I ordered on what passed in front of me without taking into account that the products could be fake; But I had to have some clean stuff.

( In my troubles with the sarms I was not really vigilant )

 

[PoSiTiVeFLoW]

November/December last year I was using 9mg injectable Sr and 10 to 20mg cardarine while I was training for boxing and it was without a doubt the leanest and best endurance I had in over 15 years. Now obviously the training I was doing was a big part of it but during the time I was on those 2 things my 1 hour workouts with 4 to 6 rounds of heavy bag and mits turned into 2hr workouts and 8 to 10 rounds on the heavy bag, 3 to 4 round sparing sessions and I still would do some weight training after those workouts.

I definitely lost some muscle and strength but I also cut 30lbs in the process and my bf wasn't very high to begin with.

I did not have injectable SR-9009 but it certainly gave me the leanest and extreme endurance for resistance cardio I hadn't felt in a long time if ever.. so that feeling was common. I wonder if cyclosomal/liposomal oral delivery methods could help or a transdermal delivery possible?

I remember the 2% oral bioavailability studies you mentioned I'd have to actually read them to see if it fully applies... Problem is I'm swamped reading scientific white papers, doing R&D and product management for my day job, so I never get to give this subject the real reading it deserves..

 

[Oliver Kween]

If anyone has a link for SR in TD, I'm ready.

to prolong the SR there was this study on about DMSO
But I'm too far from all that to understand The Relationship between Solubility and Transdermal Absorption of Tadalafil - PMC (nih.gov)



Is it stupid, taking an oral with grapefruit or pineapple or lemon juice could increase bioavailability?

What Is Bromelain Good For? 7 Health Benefits & Side Effects

Bromelain is a naturally occurring substance that is derived from pineapples. Bromelain may be good for digestion, removing dead skin cells from burns and reducing inflammation, swelling, muscle soreness, pain and nasal congestion.

www.medicinenet.com

 

[PoSiTiVeFLoW]

If anyone has a link for SR in TD, I'm ready.

to prolong the SR there was this study on about DMSO
But I'm too far from all that to understand The Relationship between Solubility and Transdermal Absorption of Tadalafil - PMC (nih.gov)



Is it stupid, taking an oral with grapefruit or pineapple or lemon juice could increase bioavailability?

What Is Bromelain Good For? 7 Health Benefits & Side Effects

Bromelain is a naturally occurring substance that is derived from pineapples. Bromelain may be good for digestion, removing dead skin cells from burns and reducing inflammation, swelling, muscle soreness, pain and nasal congestion.

www.medicinenet.com

I'm curious if the SR9009 powder can have the microparticle lipid or cyclosomal coatings for oral, but hell yeah if DMSO works for a carrier and one can use Cialis with it transdermally. Thanks for the papers I'll take a read.. back to day job stuff.

So the grapefruit juice works with opioids availability and potency cause of certain enzymes (bio catalysts) in those juices amplify the effects with the opioids receptors. Not sure it would work with SR9009, but hey might as well give a shot.

 

[Oliver Kween]

Yeah, I was kinda thinking the same thing.

The effect will be increased but not the bioavailability.

Glad to have found something that interested you.

 

[chainsaw]

November/December last year I was using 9mg injectable Sr and 10 to 20mg cardarine while I was training for boxing and it was without a doubt the leanest and best endurance I had in over 15 years. Now obviously the training I was doing was a big part of it but during the time I was on those 2 things my 1 hour workouts with 4 to 6 rounds of heavy bag and mits turned into 2hr workouts and 8 to 10 rounds on the heavy bag, 3 to 4 round sparing sessions and I still would do some weight training after those workouts.

I definitely lost some muscle and strength but I also cut 30lbs in the process and my bf wasn't very high to begin with.

9mg a day? How long did you run it?

Also didn't know they had injectable sr9009. Did it have any effect in hpta or require pct?

 

[patrick25]

I'm on topical sr-9009 week 3. 40 mg dmso with ac262 20 mg. week3. Strength is definitely up I'll check the scale at week 8 to see if it's placebo or not.

 

[Smont]

9mg a day? How long did you run it?

Also didn't know they had injectable sr9009. Did it have any effect in hpta or require pct?

As far as I know it's not supressive, but I'm on testosterone indefinitely so it's not something I pay a lot of attention to. I was on it for the last month of my cut. So approximately 30 days or so.

I started out pinning 3mg in the delts 3 times a day but that got old fast so I went to 4.5mg 2x day sub q and there was a few times I pinned 9mg in the muscle pre workout to see if there was a significant difference but I didn't notice a change.

If it didn't have to be pinned so damn frequently I would use it more often. I tried finding transdermal but I couldn't find a reputable company that carried it.

 

[Smont]

I also wanna add that u didn't notice the effects immediately, at first I thought nothing was happening. But one day I was doing 3 minute rounds on the heavy bag and I had my headphones in and I wasn't paying attention to the timer and before I knew it I had gone through 3 rounds without taking a break and I wasn't tired at all. At that point I realized it was working so I started pushing my limits

 

[Smont]

And I lied. I just looked in my old training journal and I started at 9mg and went to 12mg week 3 and 15 week 4. My apologies for the confusion.

The last 9 days I did 6mg subq in the morning and another 9mg pre workout.

I often will fiddle with dose timing and forget I did it.

 

[PoSiTiVeFLoW]

Alright y'all go google Cutz 2.0 at Pureraws or transdermal sr9009 at behemoth labs. Bit pricey to go transdermal SR9009 but the cutz 2.0 with the transdermal Sr9009 + cardarine + yohimbine looks pretty nice to me from purerawz... same price as large 60mL bottle of TD SR9009 from behemoth. I never ran the cardarine, hopefully the yohimbine helps and doesn't over stim it.

 

[Oliver Kween]

I'm on topical sr-9009 week 3. 40 mg dmso with ac262 20 mg. week3. Strength is definitely up I'll check the scale at week 8 to see if it's placebo or not.

Yup, is ac262 cousin with ACP? I have a 30ML of ACP but I do a lot of research before using it. And apart from being an Andarine-like, I have to be sure of its effects. Have you used ACP?

I also wanna add that u didn't notice the effects immediately, at first I thought nothing was happening. But one day I was doing 3 minute rounds on the heavy bag and I had my headphones in and I wasn't paying attention to the timer and before I knew it I had gone through 3 rounds without taking a break and I wasn't tired at all. At that point I realized it was working so I started pushing my limits

It's exactly that. There's a long time when I took it even for Liquid these effects were instantaneous. It was in my debut, there may be something to play on it. I felt the difference because sometimes I put on a 20kg (45 lbs) weighted vest to go to the gym for 3km (2 miles?) with the sports bag full with everything. One day with SR I was more comfortable than usual. I did 2 hours of krav and 2 hours of MMA without feeling too tired.

 

[Jeremyk1]

Alright y'all go google Cutz 2.0 at Pureraws or transdermal sr9009 at behemoth labs. Bit pricey to go transdermal SR9009 but the cutz 2.0 with the transdermal Sr9009 + cardarine + yohimbine looks pretty nice to me from purerawz... same price as large 60mL bottle of TD SR9009 from behemoth. I never ran the cardarine, hopefully the yohimbine helps and doesn't over stim it.

Would yohimbine even be stimulating topically?

 

[djbombsquad]

Maybe sr9009 with some absorption ingredient

 

[djbombsquad]

Would yohimbine even be stimulating topically?

Transdermal ? I saw the site s4 transdermal ?

 

[KvanH]

Would yohimbine even be stimulating topically?

I think @Hyde has used topical Y. I've also used this product called Yohim Flame, but couldn't tell, if I got anything out if it.

 

[Oliver Kween]

Maybe sr9009 with some absorption ingredient

Excluding DMSO,

Apart from Propylene glycol (used in Androhard) and Palmitoyl Oligopeptide in cosmetics. There is also coconut oil. But no idea of reaction with a Samrs or something like SR

I see no other solution

Then it will come back to making your own manufacturing workshop lol

 

[semtex7]

I'm curious if the SR9009 powder can have the microparticle lipid or cyclosomal coatings for oral, but hell yeah if DMSO works for a carrier and one can use Cialis with it transdermally. Thanks for the papers I'll take a read.. back to day job stuff.

So the grapefruit juice works with opioids availability and potency cause of certain enzymes (bio catalysts) in those juices amplify the effects with the opioids receptors. Not sure it would work with SR9009, but hey might as well give a shot.

Grapefruit does exactly increases biovailability, it inhibits a few of 450 cytochrome enzymes - most importantly - CYP3A4 which is responsible for the metabolism of around 70% of the drugs. So basically you metabolise the drug at a much slower rate and it builds up.