IMO..it's a very important question and we're just now starting to learn all of the effects of low cholesterol. Cardio-wise, nobody knows how much damage is occuring with these methyls and the resulting lipid crash. We only have anecdotal evidence and no long term studies. I worry about this because of what we don't know and because we're seeing career juicers like pro wrestlers dropping dead from heart problems. They're probably doing a lot of bad things to their hearts (constant ECA, coke, drinking, never ending cycles and heavy exertion) but something tells me methyls are a part of the picture.
Psychologically, there's quite a few links to depression, anxiety, aggression and even suicide and it appears cholesterol plays some as-yet-unknown role in serotonin production. I'm a firm believer in this theory as I experienced some pretty awful sides on both m1T and SD.
All in all, I think your liver is not at terrible risk if you keep the cycle short and add some liver support supps. It is of concern, but I worry more about the heart-mind connection.