Oraotrppin supposed to absorbed sublingually or it some how crosses the GI track. Now we assume that IGF-1 did cross GI track or delivered sublingually, then IGF-1 half life is very short, that’s why L3IGF-1 was developed at first place since it breaks down slowly in the body, no one uses plain IGF-1. Or is the IGF-1 in oratropin is long IGF-1?