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Pregnenolone is a natural hormone that cannot be patented. Back in the 1940's, when researchers started experimenting with the use of pregnenolone, they realized that it could be helpful for people under stress and it could increase energy in those who were fatigued. However, about the same time, cortisol, another closely related hormone, was discovered. Cortisol stole the limelight. When cortisol was given to individuals with rheumatoid arthritis, there were outstanding short-term improvements. Photographs of these remarkable recoveries were circulated and the medical community was impressed. Scientists basically put pregnenolone aside to focus on cortisol. The structure of cortisol was altered to make similar molecules such as dexamethasone and prednisone, much more powerful steroids. Dexamethasone and other similar corticosteroids could be patented, and thus a pharmaceutical company could make a lot of money. Pregnenolone has stayed in relative obscurity since the 1940's, with only rare mentions in the medical literature. There have been few studies published on pregnenolone in recent years, and only a couple involve human subjects.
Benefits of pregnenolone
Some people find pregnenolone improves energy, vision, memory, clarity of thinking, wellbeing, and often sexual enjoyment or libido. Pregnenolone may be considered a good brain enhancer in those who are deficient. Studies in rodents show pregnenolone to be one of the most effective and powerful memory boosters. Pregnenolone may increase levels of acetylcholine in the hippocampus and other memory regions in the brain. Some women report lessening of hot flashes or premenstrual symptoms. However, pregnenolone is not risk-free. For safer alternatives, consider Mind Power Rx natural supplement as a mind booster, Passion Rx as a sexual enhancer, MultiVit Rx for more energy, and Eyesight Rx for better vision within days.
Possible pregnenolone side effects
Overstimulation and insomnia -- low doses could be helpful for sleep when taken in the morning. For occasional sleepless nights, consider Good Night Rx.
Irritability, anger or anxiety -- low doses could actually ease a person into a relaxed feeling, while higher amounts may lead to irritability.
Acne can occur due to the probable conversion of this hormone into androgens
Headaches are possible with high dosages
Possible scalp hair loss if used daily for prolonged periods. Pregnenolone converts into DHEA, which in turn converts into testosterone and possibly on to DHT. Pregnenolone can also be converted into progesterone.
Irregularities of heart rhythm, Heart Palpitations, even on as low a dose as 10 mg. This can be serious in the elderly or those with heart rhythm disturbances.
Unknown effects on the thyroid gland or other organs and tissues.
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