NeuroSteroids- intranasal pregnenolone

[BrainWavez]

Hi! Does anyone have experience with Neurosteroids? Like DHEA, Pregnenolone Allopregnenolone,…?

I found a study https://pubmed.ncbi.nlm.nih.gov/31755558/ with intranasal pregnenolone and was going to try to make a nasal spray. They are using a proprietary gel.

I’m not sure how to dissolve it. I’m thinking ethanol and then distilled water.

Anyone tried anything like this?

 

[thebigt]

iconic formulations has transdermal pregnenolone [neuro p5]....i've applied it to forehead and temples before and it was a pretty nice buzz affect---i'm a fan of preg, maybe @delsolrob or @nostrum420 could give you some idea's---a nasal preg sounds interesting.

 

[nostrum420]

Hi! Does anyone have experience with Neurosteroids? Like DHEA, Pregnenolone Allopregnenolone,…?

I found a study https://pubmed.ncbi.nlm.nih.gov/31755558/ with intranasal pregnenolone and was going to try to make a nasal spray. They are using a proprietary gel.

I’m not sure how to dissolve it. I’m thinking ethanol and then distilled water.

Anyone tried anything like this?

You're gonna end up with some gross and/or painful stuff to put up your nose.

Typically you'd need something pretty water-soluble to attempt a nasal spray; that's why most nasal sprays are salts.

 

[thebigt]

You're gonna end up with some gross and/or painful stuff to put up your nose.

Typically you'd need something pretty water-soluble to attempt a nasal spray; that's why most nasal sprays are salts.

does sound interesting though-eh?

 

[nostrum420]

does sound interesting though-eh?

Yeah, I was just thinking about what it would take to make sodium-pregnenolone.

 

[thebigt]

Yeah, I was just thinking about what it would take to make sodium-pregnenolone.

count me as interested...preg to da head is kinda cool-intra nasal could be a thing

 

[Iwilleattuna]

Coming soon - Intra nasal high stim pre workout so you can really snort pre workout lol

 

[KvanH]

Coming soon - Intra nasal high stim pre workout so you can really snort pre workout lol

A weird OT; I lost a bet once and had to snort 200 mg of AMP citrate powder. Not fun, lol. Oh the days of youth..

 

[KvanH]

Hi! Does anyone have experience with Neurosteroids? Like DHEA, Pregnenolone Allopregnenolone,…?

I found a study https://pubmed.ncbi.nlm.nih.gov/31755558/ with intranasal pregnenolone and was going to try to make a nasal spray. They are using a proprietary gel.

I’m not sure how to dissolve it. I’m thinking ethanol and then distilled water.

Anyone tried anything like this?

You can find a lot of general info and discussion on dhea and pregnenolone by using those words and Dermacrine in the search function. Of topical and oral use.

 

[BrainWavez]

I found some information:

It’s solubility

doi:10.1002/jps.3030400117

https://moscow.sci-hub.st/162/3f55935aad79f79f26b6777ff86a0774/freedman1951.pdf

soluble in ethyl alcohol at 19mg/ml


0.019 gram per cc ethanol
0.081 gram per cc benzyl alcohol


This study they dissolve it in sodium dodecyl sulfate, but then add it with peanut oil for injection.

Pregnenolone Rescues Schizophrenia-Like Behavior in Dopamine Transporter Knockout Mice

Pregnenolone belongs to a class of endogenous neurosteroids in the central nervous system (CNS), which has been suggested to enhance cognitive functions through GABA[A] receptor signaling by its metabolites. It has been shown that the level of pregnenolone ...

www.ncbi.nlm.nih.gov

0.2% sodium dodecyl sulfate (SDS)


Pregnenolone (Preg) (Sigma-Aldrich) was dissolved in a minimal volume of 0.5% SDS and resuspended in peanut oil. The vehicle solution was a minimal amount of 0.5% SDS in peanut oil. All injections were performed with a 5 ml/kg injection volume.

 

[BrainWavez]

I found some information:

It’s solubility

doi:10.1002/jps.3030400117

https://moscow.sci-hub.st/162/3f55935aad79f79f26b6777ff86a0774/freedman1951.pdf

soluble in ethyl alcohol at 19mg/ml


0.019 gram per cc ethanol
0.081 gram per cc benzyl alcohol


This study they dissolve it in sodium dodecyl sulfate, but then add it with peanut oil for injection.

Pregnenolone Rescues Schizophrenia-Like Behavior in Dopamine Transporter Knockout Mice

Pregnenolone belongs to a class of endogenous neurosteroids in the central nervous system (CNS), which has been suggested to enhance cognitive functions through GABA[A] receptor signaling by its metabolites. It has been shown that the level of pregnenolone ...

www.ncbi.nlm.nih.gov

0.2% sodium dodecyl sulfate (SDS)


Pregnenolone (Preg) (Sigma-Aldrich) was dissolved in a minimal volume of 0.5% SDS and resuspended in peanut oil. The vehicle solution was a minimal amount of 0.5% SDS in peanut oil. All injections were performed with a 5 ml/kg injection volume.

 

[Renew1]

 

[KvanH]

View attachment 211071

Now what the hell kind of search word you used to find that pic..

 

[BrainWavez]

I found this:

Pregnenolone Nasal Spray

What Are the Main Benefits of Taking Pregnenolone? 1. Cognitive & Memory Function Taking pregnenolone can have a fantastic effect on your cognitive function, as it helps to increase the growth …

gorillahealing.com

Doesn’t seem like it is for sale.

Ingredients: Sterile Saline, BA, Pregnenolone Powder.

What do you think “BA” is?
Bacteriostatic water?

 

[Renew1]

I found this:

Pregnenolone Nasal Spray

What Are the Main Benefits of Taking Pregnenolone? 1. Cognitive & Memory Function Taking pregnenolone can have a fantastic effect on your cognitive function, as it helps to increase the growth …

gorillahealing.com

Doesn’t seem like it is for sale.

Ingredients: Sterile Saline, BA, Pregnenolone Powder.

What do you think “BA” is?
Bacteriostatic water?

BA is Benzyl alcohol.

 

[BrainWavez]

BA is Benzyl alcohol.

Thanks! I’m going to give it a try.

VALTOCO (diazepam nasal spray) has benzyl alcohol.


Another study on intranasal pregnenolone’s benefits.

Promnestic effects of intranasally applied pregnenolone in rats

The neurosteroid pregnenolone (PREG) has been shown to have memory-enhancing and anti-depressant action. The present study addresses the question of w…

www.sciencedirect.com

 

[KvanH]

Question; why a nasal spray and not a topical or oral supp?

 

[BrainWavez]

In this study https://pubmed.ncbi.nlm.nih.gov/31755558/

It shows it targets the brain directly on the same side as nostril applied.

I’m thinking I can use a smaller amount, than other routes of administration, and get rapid results.

 

[KvanH]

In this study https://pubmed.ncbi.nlm.nih.gov/31755558/

It shows it targets the brain directly on the same side as nostril applied.

I’m thinking I can use a smaller amount, than other routes of administration, and get rapid results.

On same side as nostril applied? Didn't undesrstand.. ?

Oral administration should give rapid effects too. And topical needs smaller amount (than oral). And plenty of oral and topical preg readily available, that's just why I'm asking.

 

[thebigt]

On same side as nostril applied? Didn't undesrstand.. ?

Oral administration should give rapid effects too. And topical needs smaller amount (than oral). And plenty of oral and topical preg readily available, that's just why I'm asking.

i highly suggest applying neuro P5 [topical preg] directly to forehead/temple area.

MERRY CHRISTMAS

 

[BrainWavez]

In the study it is applied to one nostril and shown to only reach the side of the brain it is applied. It doesn’t have to travel through the entire body/systemically.

 

[BrainWavez]

Merry Xmas! Hoho

 

[KvanH]

In the study it is applied to one nostril and shown to only reach the side of the brain it is applied. It doesn’t have to travel through the entire body/systemically.

Hmm, that's interesting. Maybe there are receptors on both sides, but does it matter where they are activated? I dunno, just spit balling. And too lazy to read the study right now. I only know about the left and right side of the brain having different properties, like logical/analytical thinking (left) vs creative/'artistic' (right). Don't know how inserting preg to only one side of the brain will affect. If that indeed is what's happening with nasal application and if it's even possible.

 

[thebigt]

In the study it is applied to one nostril and shown to only reach the side of the brain it is applied. It doesn’t have to travel through the entire body/systemically.

back in the day i had access to pure mescaline before it had been cut and capped...the amount needed was very small, many times in snorted it up 1 nostril and it worked magnificently....of course that was a different lifetime.

 

[pixel8mb]

I read that study and wondered the same thing, why one nostril? It seems they were measuring the amount of Preg in the brain after administering it via one nostril, and found higher amounts in the same side of the brain as the side of nostril used when administering the spray, and that proved that the nasal administration was effective in getting Preg into the brain... I think they compared it to other methods of administration like IV, which resulted in higher amounts of Preg in both sides of the brain... That's my guess anyway...

In the study it is applied to one nostril and shown to only reach the side of the brain