I knew I could find it. For those that think they need Vitex or Bromo or whatever for the use of Tren and/or Deca gyno, Nolva is your best bet. From the theroy it seems prolactin is much more involved (as everyone speculated) and either Tamoxifen and/or Raloxifene reduces prolactin significantly.
Antiestrogenic properties of raloxifene.
Draper MW, Flowers DE, Neild JA, Huster WJ, Zerbe RL.
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
This 21-day, open-label study evaluated the effects of raloxifene and tamoxifen on estrogen-induced changes in serum levels of anterior pituitary hormones (prolactin, luteinizing hormone, and follicle-stimulating hormone), sex steroids (testosterone, estradiol), and binding globulins [thyroid binding globulin (T3 resin uptake), transcortin, sex steroid binding globulin]. Seventeen healthy male volunteers completed the study after being randomized to one of three treatments: raloxifene, tamoxifen, or placebo. Six subjects received raloxifene (200 mg daily) for 10 days, 6 subjects received tamoxifen [20 mg twice a day (b.i.d.)] for 10 days, and 5 subjects received placebo for 10 days. All subjects received ethinyl estradiol (20 micrograms b.i.d.) for 7 days starting 3 days after initiation of study drug or placebo treatment. Results of the primary analysis of this study indicate that for six of the seven analyzable parameters of estrogen action (excluding luteinizing hormone) raloxifene blunted the estrogen response; this effect was significant only for T3 resin uptake. Tamoxifen administration significantly blunted or reversed the estrogen effect in all six of these parameters. Raloxifene, an effective antiestrogen in animal models, is also antiestrogenic in humans.
"Anyway, when ethinyl estradiol was given, prolactin increased by 2.96 ng/ml above baseline in the placebo group. Tamoxifen completely reversed this leading to a drop of 1.29 ng/ml below baseline. Raloxifene only blunted the increase: after raloxifene administration, prolactin remained elevated by 0.85 ng/ml."
Testosterone-induced hyperprolactinaemia in a patient with a disturbance of hypothalamo-pituitary regulation.
Nicoletti I, Filipponi P, Fedeli L, Ambrosi F, Gregorini G, Santeusanio F.
A case of a patient with hypopituitarism due to a disturbance of hypothalamo-pituitary regulation is presented, who developed high-grade hyperprolactinaemia after the initiation of substitutive therapy with testosterone esthers.The increase in serum Prl was strictly related to testosterone aromatization to oestradiol, since anti-oestrogen compounds were effective in reducing (clomiphene) or abolishing (tamoxifen) the enhanced Prl secretion. The oestrogen effect in raising Prl release was not attributable to a reduction in the dopamine inhibition of Prl-secreting cells, as the dopamine-antagonist domperidone failed to increase Prl serum levels in the same patient. This suggests that, in man, the oestrogen effect in enhancing Prl release is mainly enacted directly on the pituitary lactotrophs rather than exerted through a reduction in the hypothalamic dopamine ..
As Nandi put it:
"So for those people worried about the (IMO non-existent) prolactin induced gyno, tamoxifen looks like it would be an effective treatment. Another reason to forget the foolish use of bromocriptine to treat gyno and just stick with the tried and true Nolvadex."
Meditation? Yoga? Tai Chi? lol
