Hi coop,
Always helping out people and trying your best to explain when so much involved is very difficult I know. One question am often noticing you will define things then listing what you think the best, but an example melatonin in even small doses make me awful groggy next day when GABA does this not at all. So it is seeming that to say is the "Best" would intake to many factors for such broad statement.
Like some drug may acutely address symptom the best but overall would not be the "best" drug, rather another drug that addressing symptom as well but suited more properly.
Only bringing to attention as some may read start on the melatonin or any other thing thinking the best and that all there is to it, but maybe not for them, friend I have would tell me taking melatonin he is feeling depressed for a week and he not prone to depression but those that are also maybe it will be less optional.
Everyone like to be a critic lol please understand am only trying to help