L-Theanine is a natural phytochemical found in Japanese green tea. L-Theanine is a non-essential amino acid that is present in the brain and is a close relative of Glutamate. Studies indicate that L-Theanine interacts with the neurotransmitter, GABA (Gamma-Aminobutyric Acid). GABA, known for its importance in nervous system functioning, works with the mood centers of the brain. Studies in Japan show that L-Theanine helps support the body's ability to deal with PMS and occasional, everyday anxiety. L-Theanine is a unique amino acid found almost exclusively in the green tea plant (Camellia sinensis) and is the primary ingredient contributing to the unusual taste of green tea. Animal studies have shown that L-Theanine crosses the blood brain barrier, increases dopamine and GABA levels in the brain, and inhibits the stimulatory properties of caffeine. Human studies have shown that taking L-Theanine results in the emission of brain waves associated with a state of relaxation. L-Theanine exerts beneficial effects on brain metabolism and induces relaxation without causing drowsiness, as measured by increased generation of alpha-waves. L-Theanine may improve learning ability and sensations of pleasure by affecting dopamine and serotonin neurotransmitters in the brain. Also, L-Theanine exerts protective effects on the brain by antagonizing glutamate toxicity. L-Theanine helps promote a restful, relaxed state while maintaining daytime alertness. L-Theanine is also scientifically shown to support healthy blood pressure levels that are already within normal range. First, look at the bottle and report back on the extract. If it's not standardized, chuck it and get something that's at least 20% standardized. 50% would be better and AS Forskolin-95 would be optimal, but it is expensive. Here's what you need to know: Cyclic AMP: Forskolin activates adenylate cyclase, the enzyme that converts adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP). cAMP is an activator of protein kinase A (PKA). PKA, however, has been shown to phosphorylate a serine residue on PLC, which is thought to indirectly cause its inactivation. Effects of beta-agonists on airway epithelial cells. (ephedrine is a beta-agonist) Abstract beta-Adrenergic receptor (betaAR) agonists exert a variety of effects on airway epithelial cells. Among their best known actions is their ability to increase ciliary beat frequency, mediated by cyclic adenosine monophosphate (cAMP) production, stimulation of protein kinase A (PKA), and phosphorylation of an outer dynein arm light chain. Submucosal glands express betaARs, and beta-agonists may stimulate secretion of mucus from airways, although human data are controversial. beta-Agonists may also affect ion transport across epithelial cells by opening apical ion channels such as the cystic fibrosis transmembrane regulator. This effect, likely to occur in submucosal glands, can influence water fluxes across the airway epithelium and may have profound influences on mucus hydration. betaAR activation can increase intracellular calcium in some ciliated cells, thereby stimulating ciliary beating and possibly influencing transepithelial ion transport. betaAR-mediated activation of cAMP-dependent protein kinase accelerates epithelial cell migration, thereby enhancing epithelial wound repair. beta-Agonists reduce the ultrastructural damage seen with infection and potentiate secretion of certain cytokines from epithelial cells while inhibiting secretion of others. Finally, beta-agonists may have effects on airway epithelial cells that are mediated through betaARs but do not require cAMP production. The signaling mechanisms of some beta-agonist effects are not well understood but are important to our understanding of airway epithelial cell growth, differentiation, and function. In english: the two ingredients work in tandem and you'll get more for your money when you add forskolin to EC.