High doses of nandrolone decanoate reduce volume of testis and length of seminiferous

[Beelzebub]

High doses of nandrolone decanoate reduce volume of testis and length of seminiferous tubules in rats.

Noorafshan A, Karbalay-Doust S, Ardekani FM.

Shiraz University of Medical Sciences, Shiraz, Iran. [email protected]

Anabolic-androgenic steroid (AAS) compounds rank among the drugs most widely abused with the goal of improving athletic ability, appearance, or muscle mass. It has been shown that these compounds have adverse effects on human and animal physiology and sperm quality, but quantitative structural changes of the testis have received less attention. The present study was conducted to evaluate the effects of nandrolone decanoate, which is one of the AAS compounds, on testis weight and volume, diameter and length of seminiferous tubules in rats by unbiased stereological methods. Adult rats were divided into three groups. The first comprised control rats; the second and third groups received low and high doses of nandrolone decanoate for 14 weeks. The rats were then left untreated for 14 weeks. After removal of the testis, stereological study of these tissues showed that the mean volume of testis and length of the seminiferous tubules in the animals that received high doses of nandrolone decanoate were reduced approximately 32% (p<0.01) and approximately 31% (p<0.04), respectively, in comparison with the control group. It can be concluded that the high doses of nandrolone decanoate produce structural changes in the rat testis that remain 14 weeks after stopping injection of the drug.

PMID: 15723686 [PubMed - in process]

 

[Beowulf]

After removal of the testis, stereological study of these tissues showed that the mean volume of testis and length of the seminiferous tubules in the animals that received high doses of nandrolone decanoate were reduced approximately 32% (p<0.01) and approximately 31% (p<0.04), respectively, in comparison with the control group.[PubMed - in process]

Man, am I glad I'm not a lab rat. :box: They should have at least given the poor fucker some clomid before they neutered him, so that he could have died with some shred of respect.

 

[ChemicalD]

Man, am I glad I'm not a lab rat. :box: They should have at least given the poor fucker some clomid before they neutered him, so that he could have died with some shred of respect.

For real. But does the article mention what the mg/kg doses were? I mean, we could be talking huge amounts administered to these rats. Nonetheless, another err on the side of caution.:think:

 

[Poobah]

hehe... poor basterds.

But I'm not surprised at all.. It's deca afterall.

 

[glenihan]

ok ... so we now know that your nuts shrink while you're on gear and if you don't do PCT they won't come back ... got it

 

[Beowulf]

ok ... so we now know that your nuts shrink while you're on gear and if you don't do PCT they won't come back ... got it

Exactly, that was my point about giving the poor fuckers some clomid.

 

[Beelzebub]

Exactly, that was my point about giving the poor fuckers some clomid.

don't mind glenihan, diet makes him grumpy. :hammer:

 

[Neuromancer]

don't mind glenihan, diet makes him grumpy. :hammer:

I figured it was his lack of calves...

 

[Beelzebub]

I figured it was his lack of calves...

a combination thereof. :whip:

 

[CEDeoudes59]

poor rats.

 

[chasec]

**** the rats, i just got some deca for myself.... oh well, i have plenty of testicles to spare:trout:

 

[glenihan]

don't mind glenihan, diet makes him grumpy. :hammer:

that's so true it hurts .. thank god test makes me happy


that calves comment was low ... although very funny