I posted this (or similar) elsewhere in the MK-677 discussion thread but maybe it'll help you a bit.
Before we compare MK-677 to GH as a "replacement" lets cover the following:
1. By age of 30, our HGH levels are only about 20 percent of their peak levels during childhood
2. Past age 30, GH levels continue to decline at a rate of about 12-15% every 10 years
3. Benefits of HGH:
a. Reduce excess body fat
b. Increase muscle mass
c. Reduce wrinkling of the skin and some other effects of skin aging.
d. Re-grow certain internal organs that have atrophied with age.
e. Increase bone density.
f. Strengthen the immune system.
g. Possibly reverse cognitive decline.
h. Stimulate production of the bone marrow cells that produce red blood cells.
i. Slow the progression of cardiovascular disease
j. Improve lipid profile
4. MK-677 compared to iu's (someone check my math on this one just in case)
a. Human growth hormone is measured in iu (international units) and mg. 1 mg equals approximately 3 iu, while 1 iu equals approximately 0.33 mg.
b. 24-h mean GH in young normal men is 1.16µg/l, with a range of 0.67–2.35µg/l and a clinical reference range for males of <3 µg/L
c. Natural GH production for a normal male as measured by iu's would be 1-2iu daily (excluding puberty)
d. MK-677 can increase mean production of GH by up to 183%. This would mean an increase of 1.83 - 3.66iu per day.
e. This increase in GH results in a corresponding increase of IGF-1 levels by 39-94%.
After considering the above, MK-677 is not really a replacement for traditional GH as it only allows your body to "max out" what it is capable of producing naturally. While completely unrelated, it reminds me of clomid, which can max out the level of natural test production your body is capable of, but not much past that.
Most users of Ghar1ne that I've seen logs for notice:
- improved skin
- better/deeper sleep
- positive body composition
- increased hunger
- increased water retention/bloat while on
- faster/improved recovery after workouts
Hope that helps man.