I did this years ago. I just found an old article and there is a thread as well.
http://www.mindandmuscle.net/articles/kick-it-up-a-notch-how-to-enhance-your-lipoderm-for-greater-fat-loss/
Capsaicin is the stuff in peppers that gives them their hot taste. Of interest here is that, when nerves are exposed to capsaicin, they release a very large amount of CGRP. Of course, too much CGRP and you can actually damage the nerve permanently. Curiously, by permanently damaging capsaicin-sensitive nerves, rats and mice actually get leaner. For example, in one study researchers took mice and desensitized them to capsaicin by giving them a very large dose of the compound at the age of 1.5 months. They then compared those mice with matched controls at one year of age. What they found was that that the desensitized mice had 9% less epididymal and 30 % less retroperitoneal fat than the controls. This was due to a reduction in the number of fat cells. The authors proposed that by desensitizing the capsaicin-sensitive neurons they attenuated the normal age-associated increase in CGRP activity and thus promoted whole body insulin insensitivity.
Now it’s entirely questionable if humans would have a similar reaction, as rats and mice use their capsaicin-sensitive neurons to regulate thermogenesis in their brown fat tissue. So, we could be witnessing some kind of interaction with the brown fat thermogenesis system, which in turn causes this leanness. Now, much can be said about capsaicin as a fat loss aid at least in rats. But we are kind of getting off track.
What we really want to do for our purposes is provide a small dose of capsaicin to the nerve tissue that surrounds our subcutaneous adipose tissue. This way CGRP is released in this region resulting in localized insulin resistance, which should enhance fat loss from the targeted area. Furthermore CGRP is one of the most potent—if not the most potent –vasodilator naturally produced by the human body. So, it should substantially increase blood flow to the area, allowing for removal of the fatty acids that are released by Lipoderm’s lipolytic ingredients.
http://www.mindandmuscle.net/forum/5734-spooky-lipoderm-ultra
Here is my run -
http://anabolicminds.com/forum/avant-research-labs/84634-topical-liquid-capzasin.html