I was going to say something similar, as Nac said. Generally - enhaced or not - starting a cut with a huge deficit is a bad approach, due to multiple reasons. If your calorie expenditure is truly 3 000 kcals, then I would start cutting at 2 500 kcals, for example. And track progress and decrease calories, as you proceed.
It's tough to say anything definitive, if one might/will lose muscle on a cut, wether enhanced or not. But I'd say it's very likely for you to not lose any muscle, if you do things well. As you have quite a bit to lose, you don't have to starve yourself to lose fat, at least for several weeks in the beginning. I would start with reasonable deficit, go trough the first 'easy' weeks without gear (like 4-6) and then add in the PED's and continue the momentum, while adequately dropping calories.