thebigt
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i did family bbq yesterday...got up today planning to mow grass, it was raining so i went back to bed...
double s
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Ahh Sunday, while everyone stays asleep, Daddy is weightlifting...
Still shaking the 4th rust so high rep shoulder workout
PWO with CitMal...took AGM before bed, trying something new.
25 mins on treadmill
Straightbar Shoulder presses - 6 sets 15-25 reps, always making sure I lower the bar no more than my nose and elbows parallel to the ground
Straight bar shrugs 5 sets 15-20 reps
15 more mins Cardio 3.5 mph
Be well
Still shaking the 4th rust so high rep shoulder workout
PWO with CitMal...took AGM before bed, trying something new.
25 mins on treadmill
Straightbar Shoulder presses - 6 sets 15-25 reps, always making sure I lower the bar no more than my nose and elbows parallel to the ground
Straight bar shrugs 5 sets 15-20 reps
15 more mins Cardio 3.5 mph
Be well
R1balla
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Are you having an increase in acne?
double s
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No, continuing to take the Divamax 3x a day but can't quite say I feel much of a difference.
Today short brisk workout
30 mins treadmill, 2 degrees, 4.1 mph
Bi's
Straight bar curls, elbows slightly tucked behind my back
45, 55, 55,65 - really forcing the biceps and forearms
Curl bar wide grip 45, 65, 75, 75
Have a great Monday :34:
R1balla
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Well my acne has increased this past week. I started when all the logs started.
thebigt
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looks like you are coming up on 3 weeks, hopefully you will be seeing effects soon....nice looking chick, btw!!!
double s
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Sofia Vergara...
Aside from the Divamax I am very pleased with the both the Agm ans Citmal (aside from the taste). Love it soo much just did a quick workout with the wife
To follow up on bi's
Did 3 sets of forearm curls, straight bar
Tris
Skullcruchers 4 sets 65 lbs 12-15 reps
Tricep pushdowns with 3 rubber band cords
3 sets of behind the head extensions with 35 lb plate
Do you use the CLA? I am on the fence with trying it...seems it comes and goes every few years and with dieting.......hmmm
thebigt
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not using cla now, i am going to try the entire biocor lineup soon if budget permits. at my age i am more interested in the cissus, that is one biocor product i am for certain going to be using soon!!!
double s
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Cissus for joints or something else?
thebigt
Legend
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mostly for the joints...cissus is one of those compounds that doesn't get a lot of hype, but i bet many cycle it or even use as a staple!!!
start a thread in supplement section and ask how many are using cissus...i bet you would get a huge response!!!
double s
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Another day another dollar.....back in the saddle today
Changed things up a bit, noticed once and while when mixing my PWO with Citmal and AGM that I get pressure buildup in my head and some vasoconstriction in my eyes which lasts for an hour or 2. Knew I wasn't going to get alot of sleep last night so had Divamax and Agm last night and PWO and Citmal this morning..
15 mins on treadmill
Hamstrings...weakest part on my body
Stiff leggs (curl bar)
bar - 15 reps
45lbs - 15 reps
65lbs - 15 reps
85lbs - 15 reps
85lbs - 15 reps
90lbs - 15 resps
Not a great day but time for stretching......thx for reading!
Great watch if you have never seen this....
[video=youtube;MaTw-GjFtVo]http://www.youtube.com/watch?v=MaTw-GjFtVo[/video]
Changed things up a bit, noticed once and while when mixing my PWO with Citmal and AGM that I get pressure buildup in my head and some vasoconstriction in my eyes which lasts for an hour or 2. Knew I wasn't going to get alot of sleep last night so had Divamax and Agm last night and PWO and Citmal this morning..
15 mins on treadmill
Hamstrings...weakest part on my body
Stiff leggs (curl bar)
bar - 15 reps
45lbs - 15 reps
65lbs - 15 reps
85lbs - 15 reps
85lbs - 15 reps
90lbs - 15 resps
Not a great day but time for stretching......thx for reading!
Great watch if you have never seen this....
[video=youtube;MaTw-GjFtVo]http://www.youtube.com/watch?v=MaTw-GjFtVo[/video]
R1balla
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awesome video
double s
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Captains Log Stargate neptune, day 114 of the Biocor Chronicles.....all systems full functional
No cardio today, knee has been tweaking with a nice pop from time to time
Back on the agenda
4 sets of pull ups
Straight Bar rows - 115, 135, 155, 165, 165
Not sure of name but laying flat on bench and with a 35 lb plate stretching behind head and back to chest, kind of like skull crunches - 4 sets
Started this journey at 190 lbs, now down to 178.2, feeling strong and looking great! Have to pick my clothes wisely as some are starting to hang a little too loose which is good and bad...
No cardio today, knee has been tweaking with a nice pop from time to time
Back on the agenda
4 sets of pull ups
Straight Bar rows - 115, 135, 155, 165, 165
Not sure of name but laying flat on bench and with a 35 lb plate stretching behind head and back to chest, kind of like skull crunches - 4 sets
Started this journey at 190 lbs, now down to 178.2, feeling strong and looking great! Have to pick my clothes wisely as some are starting to hang a little too loose which is good and bad...
double s
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Interesting article http://examine.com/supplements/Agmatine/
Agmatine is a biogenic amine that is derived from L-arginine via decarboxylation (removal of a carboxylic acid group), and appears to be stored in neurons and released upon neuronal activation. Due to this and other properties, agmatine is a seen as a neurotransmitter or at least a neuromodulator. It's most relevant and interesting potential uses (research, overall, is preliminary) include the treatment of neuropathic pain, drug addiction, and protecting the brain from toxins and stroke.
Agmatine is known as a pleiotropic molecule, and has a large amount of direct mechanisms. These include inhibition of NMDA receptors and possibly also nicotinic acetylcholine receptors, and activation of imidazoline receptors; there is possibly activation of α2-adrenergic receptors but this is not 100% clear (some studies suggest that there is no effect). Agmatine also directly inhibits NOS enzymes (aside from iNOS, at concentrations too high to be concerned with) and may also inactivate these enzymes (more biologically relevant), but despite this apparent inhibition of Nitric Oxide metabolism it appears to directly act as a mimetic and circumvent its own inhibition; the result is somewhat of a regulation of nitric oxide in instances where it is improperly elevated. Other direct mechanisms include inhibition of calcium channels (fairly potent, with an IC50 value of 1.2µM) and inhibition of serotonin receptor subset 5-HT3.
Other mechanisms which are not ascertained if they are direct or vicariously through one of the aforementioned ones include activation of PI3K/Akt (found in multiple cell lines) and adenyl cyclase activation (noted in the prefrontal cortex, it is unsure if this is from serotonin or adrenergic receptors). A release of opioids (β-endorphins) has also been confirmed to be secondary to imidazoline receptor activation in the adrenal glands, and Ryanidine receptors are activated (which release intracellular calcium) although it is not sure if this causes or is a result of the nitric oxide interactions.
Agmatine has a large number of roles and mechanisms in the body. The primary four roles (that seem to be most important) involve positively influencing imidazoline receptors and α2-adrenergic receptors while inhibiting NDMA receptors and NOS enzymes
In regards to pain, there are mixed effects (as agmatine appears to have a modulatory role) but overall it appears to be analgesic. While agmatine in isolation can augment the perception of pain (by enhancing the signalling through a receptor known as ASIC3 that mediates pain associated with acidity), it appears to release β-endorphin and synergistically enhance the actions of any opioids. Due to the inherent release of a weak opioid and synergism with opioids, agmatine is able to reduce pain and pharmaceutically is synergistic with both morphine and fentanyl (increasing pain killing, reducing tolerance, and reducing addiction).
The ability of heat to cause pain in rats is normally reduced by cannabinoid signalling (such as Marijuana), and agmatine also appears to provide synergistic pain relief with cannabinoids. Other potential synergisms between agmatine and marijuana are not yet investigated, but it appears that anything through the CB1 receptor is augmented under the influence of agmatine.
Agmatine has both pro-pain and anti-pain mechanisms (technically speaking), but it appears that due to being very synergistic with established anti-pain pathways that the overall effect of agmatine injections into research animals is one of pain relief. The pain relief is fairly notable as well
For strokes, there are repeated studies in rats using injections of agmatine (around 100mg/kg) that suggest potent protective effects that near normalization of symptoms after 3-4 days with minor protective effects noted within a few hours. It is thought that this is due to modulating nitric oxide metabolism, as the increase in iNOS seen during stroke (which normally produces too much nitric oxide and damages tissue) is attenuated while the acute suppression of eNOS (which is protective) is preserved. Nitric oxide and its oxidative metabolite known as peroxynitrate are also attenuated, and this is thought to result in less overall damage.
When cognition and brain edema are tested after a stroke, they appear to be significantly reduced and almost normalized relative to control rodents.
Although there is no human evidence at this moment in time, agmatine appears to have potent protective properties against strokes
Another claim of agmatine supplementation are the anti-addictive properties, which appear to exist in rats who become addicted to opioidergic drugs (morphine, fentanyl, and oxycodone) where agmatine injections during drug administration reduce addictive effects. There is also a potential mechanism for agmatine to reduce Nicotine dependence (which needs to be explored further) and currently the only failure has been on cocaine, which is known to be low on a rewards scale in rats; cocaine may require a human study.
Agmatine may also help with alcohol and opioid drug withdrawal by reducing symptoms thereof.
Agmatine is potentially anti-addictive, and awaits human studies to confirm what is seen in rodent models
Overall, agmatine is a highly promising research chemical that will likely be important in the future. It's usage as a common supplement is limited by a lack of human trials at this moment in time, and although there are a few studies using oral ingestion here and there (which confirm that it does appear to be absorbed) the vast majority of studies use injections of agmatine. Future research will need to re-establish all the current observations following oral ingestion (or at least, more pharmacokinetic studies should be conducted including tissue distribution so we can make educated guesses on oral doses).
Agmatine is a biogenic amine that is derived from L-arginine via decarboxylation (removal of a carboxylic acid group), and appears to be stored in neurons and released upon neuronal activation. Due to this and other properties, agmatine is a seen as a neurotransmitter or at least a neuromodulator. It's most relevant and interesting potential uses (research, overall, is preliminary) include the treatment of neuropathic pain, drug addiction, and protecting the brain from toxins and stroke.
Agmatine is known as a pleiotropic molecule, and has a large amount of direct mechanisms. These include inhibition of NMDA receptors and possibly also nicotinic acetylcholine receptors, and activation of imidazoline receptors; there is possibly activation of α2-adrenergic receptors but this is not 100% clear (some studies suggest that there is no effect). Agmatine also directly inhibits NOS enzymes (aside from iNOS, at concentrations too high to be concerned with) and may also inactivate these enzymes (more biologically relevant), but despite this apparent inhibition of Nitric Oxide metabolism it appears to directly act as a mimetic and circumvent its own inhibition; the result is somewhat of a regulation of nitric oxide in instances where it is improperly elevated. Other direct mechanisms include inhibition of calcium channels (fairly potent, with an IC50 value of 1.2µM) and inhibition of serotonin receptor subset 5-HT3.
Other mechanisms which are not ascertained if they are direct or vicariously through one of the aforementioned ones include activation of PI3K/Akt (found in multiple cell lines) and adenyl cyclase activation (noted in the prefrontal cortex, it is unsure if this is from serotonin or adrenergic receptors). A release of opioids (β-endorphins) has also been confirmed to be secondary to imidazoline receptor activation in the adrenal glands, and Ryanidine receptors are activated (which release intracellular calcium) although it is not sure if this causes or is a result of the nitric oxide interactions.
Agmatine has a large number of roles and mechanisms in the body. The primary four roles (that seem to be most important) involve positively influencing imidazoline receptors and α2-adrenergic receptors while inhibiting NDMA receptors and NOS enzymes
In regards to pain, there are mixed effects (as agmatine appears to have a modulatory role) but overall it appears to be analgesic. While agmatine in isolation can augment the perception of pain (by enhancing the signalling through a receptor known as ASIC3 that mediates pain associated with acidity), it appears to release β-endorphin and synergistically enhance the actions of any opioids. Due to the inherent release of a weak opioid and synergism with opioids, agmatine is able to reduce pain and pharmaceutically is synergistic with both morphine and fentanyl (increasing pain killing, reducing tolerance, and reducing addiction).
The ability of heat to cause pain in rats is normally reduced by cannabinoid signalling (such as Marijuana), and agmatine also appears to provide synergistic pain relief with cannabinoids. Other potential synergisms between agmatine and marijuana are not yet investigated, but it appears that anything through the CB1 receptor is augmented under the influence of agmatine.
Agmatine has both pro-pain and anti-pain mechanisms (technically speaking), but it appears that due to being very synergistic with established anti-pain pathways that the overall effect of agmatine injections into research animals is one of pain relief. The pain relief is fairly notable as well
For strokes, there are repeated studies in rats using injections of agmatine (around 100mg/kg) that suggest potent protective effects that near normalization of symptoms after 3-4 days with minor protective effects noted within a few hours. It is thought that this is due to modulating nitric oxide metabolism, as the increase in iNOS seen during stroke (which normally produces too much nitric oxide and damages tissue) is attenuated while the acute suppression of eNOS (which is protective) is preserved. Nitric oxide and its oxidative metabolite known as peroxynitrate are also attenuated, and this is thought to result in less overall damage.
When cognition and brain edema are tested after a stroke, they appear to be significantly reduced and almost normalized relative to control rodents.
Although there is no human evidence at this moment in time, agmatine appears to have potent protective properties against strokes
Another claim of agmatine supplementation are the anti-addictive properties, which appear to exist in rats who become addicted to opioidergic drugs (morphine, fentanyl, and oxycodone) where agmatine injections during drug administration reduce addictive effects. There is also a potential mechanism for agmatine to reduce Nicotine dependence (which needs to be explored further) and currently the only failure has been on cocaine, which is known to be low on a rewards scale in rats; cocaine may require a human study.
Agmatine may also help with alcohol and opioid drug withdrawal by reducing symptoms thereof.
Agmatine is potentially anti-addictive, and awaits human studies to confirm what is seen in rodent models
Overall, agmatine is a highly promising research chemical that will likely be important in the future. It's usage as a common supplement is limited by a lack of human trials at this moment in time, and although there are a few studies using oral ingestion here and there (which confirm that it does appear to be absorbed) the vast majority of studies use injections of agmatine. Future research will need to re-establish all the current observations following oral ingestion (or at least, more pharmacokinetic studies should be conducted including tissue distribution so we can make educated guesses on oral doses).
double s
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Wonderful Saturday to you all! Day off today, need time to relax a little.
Yesterday (Friday), skipped Cardio - knee still tweaking slightly.
Mixed up some BCAA's, Agm and CitMal and off to shoulders
4 sets - incline DB plate raises (35 lb plate 15-20 reps), if you haven't tried front raises on a bench, I encourage it
4 sets - side raises - I do these a little opposite where I hold for a 5 count at top, lower them almost bouncing them off my hips and holding at the top once again
4 sets - bent over rear lats
Things are winding down as I will be summarizing everything in the next few days.....
Yesterday (Friday), skipped Cardio - knee still tweaking slightly.
Mixed up some BCAA's, Agm and CitMal and off to shoulders
4 sets - incline DB plate raises (35 lb plate 15-20 reps), if you haven't tried front raises on a bench, I encourage it
4 sets - side raises - I do these a little opposite where I hold for a 5 count at top, lower them almost bouncing them off my hips and holding at the top once again
4 sets - bent over rear lats
Things are winding down as I will be summarizing everything in the next few days.....
chefbo
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ever did steering wheels with a plate before . talk about working those delts. check out sixpack shortcuts on youtube. mike chang has got it going on.
thebigt
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agmatine/cit mal are a great combo, imo.
double s
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Hi guys. I am off the grid taking a week off of training, laying new floor and preparing for Supp-Talk
I am just about done with product and will post an in depth review over the weekend
I am just about done with product and will post an in depth review over the weekend
thebigt
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get er done!!!
double s
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So I apologize as this is long overdue.
Let me start off by saying – Agmatine/CitMal combo – fantastic
Pro’s
1. Felt good and pumped within a few short days, with others there seems to be an attenuation period with some companies telling me it could be as much as 2 weeks to notice something
2. Very versatile product – can be used on its own or can be mixed in a PWO or BCAA, this is where I personally seemed to get the best bang for the buck. Don’t get me wrong, this is like 87 octane but mixing it with something else = 93 Octane
3. I lost about 7 lbs (by my design) and this seemed to help keep as much muscle as possible.
Cons
1. Agmatine by itself is nasty, I have heard some people just spoon it down, unfortunately I could not do this and personally it had to be mixed with a liquid.
Would I purchase this, most definitely, great price point and again a great addition to a PWO that is lacking these 2 ingredients.
Divamax
Unfortunately the jury is still out with me as I really didn’t feel much of a difference after about a month of use. I have heard some report libido increases where others have increased acne but for me, no reports of either. To be honest, not quite sure if I would buy this.
Aside from this definitely keep up the great work folks, will be picking up a bottle of Cissus very soon.
Let me start off by saying – Agmatine/CitMal combo – fantastic
Pro’s
1. Felt good and pumped within a few short days, with others there seems to be an attenuation period with some companies telling me it could be as much as 2 weeks to notice something
2. Very versatile product – can be used on its own or can be mixed in a PWO or BCAA, this is where I personally seemed to get the best bang for the buck. Don’t get me wrong, this is like 87 octane but mixing it with something else = 93 Octane
3. I lost about 7 lbs (by my design) and this seemed to help keep as much muscle as possible.
Cons
1. Agmatine by itself is nasty, I have heard some people just spoon it down, unfortunately I could not do this and personally it had to be mixed with a liquid.
Would I purchase this, most definitely, great price point and again a great addition to a PWO that is lacking these 2 ingredients.
Divamax
Unfortunately the jury is still out with me as I really didn’t feel much of a difference after about a month of use. I have heard some report libido increases where others have increased acne but for me, no reports of either. To be honest, not quite sure if I would buy this.
Aside from this definitely keep up the great work folks, will be picking up a bottle of Cissus very soon.
thebigt
Legend
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nice honest review...thank you for logging this!!!
R1balla
Board Sponsor
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Love the honesty man thank you for the log and great review!
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