kissdadookie
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I would say that if what iSatori claims is true, then it's good for Bio-Gro? iSatori claims that they've essentially stripped the constituents down to basically just the peptides and that supposedly leaves them in a state of low molecular weight so going by the book you linked, that helps towards getting around the issue of permeability (most of what I can tell in that book you linked, the peptides were discussed in the context of them being contained in a more complex protein chain IE milk proteins, in which to liberate the peptides, the longer chain would need to be broken down but this then leads to certain enzymes now being present which tends to destroy these peptides).
I did find this study yesterday: http://jpet.aspetjournals.org/content/283/2/611.short
That study suggests that a peptide such as IgF-1 is apparently highly bioavailable especially when casein is present. A bioavailibility of around 60%. I don't know how this will factor into humans but I couldn't find any studies of humans orally ingesting isolated IgF-1 and the studies that do discuss oral bioavailibility of IgF-1 are in the context of ingesting them whilst they are in more complex protein chains which of course is different then orally ingesting just the IgF-1 in isolation. Compared to injecting IgF-1, obviously it's more efficient and economical to inject it as opposed to orally administering it since injecting it will get it into circulation at very high doses pretty much from the get go.
There's also the fact that a lot of people poo poo on things like Deer Antler and rightfully so but I don't think they are poo pooing that in the right context. The problem with something like Deer Antler is that the stuff might contain the cytokine listed on the label but you don't actually know in what quantities, etc. A lot of people just assume that IgF-1 is just not orally bio-available and thus Deer Antler must be useless (but end of the day, the problem with Deer Antler is that you really don't know at what concentrations the listed cytokines are in, it's like buying protein powder that states it has protein but doesn't tell you how much is in it, could be a gram for all you know).
Lastly, let's not forget that products like Bio-Gro and PF3, there's a lot of other peptides in those products as well, they are not a strictly IgF-1 product, IgF-1 is just part of the constituents of the products. We know that things like proline rich peptides, IgG, and IgA have autoimmune benefits amongst other things and I think possibly anti-oxidating properties as well (could also include lactoferrin).
They didn't seem to do much of anything for DOMS and recovery in general nor did LCLT for me for that matter. I've been using them (BCAAs) since I go to the gym essentially after getting out of bed and just want some nutrients in my body as opposed to a meal since even a banana doesn't really sit well in my gut when I'm training.
