You can't put it on with your hands you need to use forearm or wrist. Some people have joint issues some don't. I'm using ph 17, dermacrine, 11 ketotestosterone and formeron 2 pumps a day with zero issues. Joint pain often has to do with inflammation. If you have joint pain my recommendation is topical celadrin on the painful joint. For prevention of inflammation use bromelaine, turmeric and cissus. Also if you use former and notice it leaving little gold flakes, wait ten minutes and apply purell hand sanitizer to the application site to allow more formeron to absorb. Formeron should help to get rid of water weight as well as any other estrogenic sides