Epistane will crash your natural test levels as will 1-andro. The combo would be low test/lethargy overload. Smarter to run a test base like Epiandro, 4-andro, DHEA, or actual test; something that actually converts to test/DHT, and that will cover the base of test that will be shut down as a result from either 1-andro, epistane, or both.
Your testes make testosterone and from there it is converted to many different compounds like DHT, estrogen, etc. When you take in a compound such as 1-andro, which converts to 1-testosterone, just slight different, your body senses the increases in hormonal levels and tells the testes to slow down/shut down testosterone production because it seems as if your have enough. Well the problem is that sure, your 1-testosterone levels are through the roof, but that doesn't behave and carry out the same functions as normal testosterone. As a result, you suffer side effects like lethargy and low libido. By simply taking a compound like DHEA or 4-andro, which will convert into normal testosterone, you can mitigate theses effects.
That's why a test base is crucial when running most compounds