Beelz is right about this. It was an old M1T thread if I remember, but I'll try to explain it again now. This is the deal: 17a-alkylated compounds enhance creatine synthesis, but at the expense of protein synthesis. Non-alkylated compounds (like test and it's 17b-esters) only increase protein synthesis but don't boost creatine production. Basically, methylation of guanidinoacetate in the body results in creatine. Donors of the methyl group are choline and methionine. Guanidinoacetate arises from a reaction between glycine and arginine. The essential aminos methionine and arginine are needed for both normal protein synthesis and the formation of creatine. Therefore, 17a-alkyl compounds stimulate the formation of creatine at the expense of cell protein synthesis because the two precursor amino acids are not optimally available for both. That means that if you take extra creatine with you're orals, you can free up more aminos for protein synthesis and that's what you really want anyway. It also makes sense to use creatine with non-alkyl compounds too because they are only concerned with cell protein and neglect creatine synthesis. So it's basically a good idea to use creatine no matter what your on! Especially with oral only cycles to optimize the effects or with ester only cycles to add the extra dimension of creatine loading. If you're stacking a high dose oral with an ester, then creatine is probably not as important in that case. Does that make sense?