Chlorophytum Borivilianum and Velvet Bean Increases GH

[JudoJosh]

A Blend of Chlorophytum Borivilianum and Velvet Bean Increases Serum Growth Hormone in Exercise-Trained Men

Abstract

Background:

Several isolated ingredients have been proposed to increase growth hormone (GH) release, including Chlorophytum borivilianum and Velvet bean. A combination of these two ingredients has been packaged within an investigational dietary supplement. It was the purpose of the present investigation to determine the impact of acute ingestion of this supplement on circulating GH in healthy, exercise-trained men.

Methods:

Fifteen men ingested the dietary supplement on two different days, separated by one week. Blood was collected from subjects before ingestion of the supplement and at 20, 40, 60, 80, 100, and 120 minutes post ingestion. GH was analyzed in serum samples using an ELISA method. Values for GH for each subject, at each collection time, were averaged over both test days and used in the main analysis.

Results:

Serum GH increased over time, with higher values at 60 minutes (1.56 ± 0.65 ng · mL−1; P = 0.04; +767%), 80 minutes (1.76 ± 0.69 ng · mL−1; P = 0.02; +878%), and 100 minutes (1.48 ± 0.62 ng · mL−1; P = 0.05; +722%) compared to pre ingestion (0.18 ± 0.04 ng · mL−1). A great deal of subject variability existed in the area under the curve (AUC) for GH, with pooled values ranging from 0.49 to 61.2 ng · mL−1 · 2 hr−1

Conclusion:

Acute ingestion of an investigational dietary supplement containing the active ingredients Chlorophytum borivilianum and Velvet bean results in an increase in circulating GH in exercise-trained men. Additional placebo controlled investigations are needed to extend these findings. Moreover, studies are needed to determine if chronic use of such supplementation leads to favorable changes in health-related parameters associated with increased circulating GH.

What is the reason for the study?
To see the impact Chlorophytum Borivilianum and Velvet Bean has on serum growth hormone (GH)

Who are the participants?
15 healthy, exercise-trained males

What was the study design?
An exploratory non-blinded trial

What was done?
The subjects reported to the lab in a fasted state on 2 different occasions separated by one week. During their visit they ingested three capsules of a dietary supplement that contained an identical concentration of Chlorophytum Borivilianum and Velvet Bean, totalling 2250 mg. No other food was allowed during the two hour post intake period. However, water was allowed ad libitum. Blood samples were taken 10min after arrival to the lab and at 20, 40, 60, 80, 100, and 120 minutes following ingestion of the supplement.

What was found?
Researchers observed an approximate 9 fold increase in circulating GH following ingestion of Chlorophytum Borivilianum and Velvet Bean.

Limitations of the study?
There was no placebo or control group used in the study. Because of this we can not really rule out the increase GH observed was not just the result of extended fasting. However, it is unlikely considering previous research has shown that GH remains relatively stable over an acute fasting period, like how was done in this study. A control group would still have been nice to rule this out though. Also I would have really liked to have seen the participants participate in some form of exercise after taking the supplement. Considering that exercise itself will stimulate a GH response, it would have been interesting to see if the addition of Chlorophytum Borivilianum and Velvet Bean would have done. Lastly, longer studies looking at various outcomes from the chronic use of Chlorophytum Borivilianum and Velvet Bean would be nice.

Takeaway?
Supplementation of Chlorophytum Borivilianum and Velvet Bean may result in an increase of serum GH levels in young exercise trained males. As was seen in this study -> http://anabolicminds.com/forum/supplement-science/262457-chlorophytum-borivilianum-velvet.html , this increase may lead to improved sleep quality as well as many other potential benefits from increased GH levels.

 

[alvin1]

what does 9 Fold mean? 9 time more Thant normal?

 

[JudoJosh]

Fold change is a measurement used to describe the change in a value over time. It is the ratio of the final value to the initial value. So if your initial value is 20 and your final value is 100, then there is a fold change of 5. This can be conceptualized as B/A with B being the final value and A being the initial value.

 

[alvin1]

So 9 time over their original level of GH secretion?

 

[koi1214]

What was done?
The subjects reported to the lab in a fasted state on 2 different occasions separated by one week. During their visit they ingested three capsules of a dietary supplement that contained an identical concentration of Chlorophytum Borivilianum and Velvet Bean, totalling 2250 mg. No other food was allowed during the two hour post intake period. However, water was allowed ad libitum. Blood samples were taken 10min after arrival to the lab and at 20, 40, 60, 80, 100, and 120 minutes following ingestion of the supplement.

Do you know the individual dose for Chlorophytum Borivilianum and Velvet Bean to equal the 2250 mg?

 

[USPlabsRep]

What is the reason for the study?
To see the impact Chlorophytum Borivilianum and Velvet Bean has on serum growth hormone (GH)

Who are the participants?
15 healthy, exercise-trained males

What was the study design?
An exploratory non-blinded trial

What was done?
The subjects reported to the lab in a fasted state on 2 different occasions separated by one week. During their visit they ingested three capsules of a dietary supplement that contained an identical concentration of Chlorophytum Borivilianum and Velvet Bean, totalling 2250 mg. No other food was allowed during the two hour post intake period. However, water was allowed ad libitum. Blood samples were taken 10min after arrival to the lab and at 20, 40, 60, 80, 100, and 120 minutes following ingestion of the supplement.

What was found?
Researchers observed an approximate 9 fold increase in circulating GH following ingestion of Chlorophytum Borivilianum and Velvet Bean.

Limitations of the study?
There was no placebo or control group used in the study. Because of this we can not really rule out the increase GH observed was not just the result of extended fasting. However, it is unlikely considering previous research has shown that GH remains relatively stable over an acute fasting period, like how was done in this study. A control group would still have been nice to rule this out though. Also I would have really liked to have seen the participants participate in some form of exercise after taking the supplement. Considering that exercise itself will stimulate a GH response, it would have been interesting to see if the addition of Chlorophytum Borivilianum and Velvet Bean would have done. Lastly, longer studies looking at various outcomes from the chronic use of Chlorophytum Borivilianum and Velvet Bean would be nice.

Takeaway?
Supplementation of Chlorophytum Borivilianum and Velvet Bean may result in an increase of serum GH levels in young exercise trained males. As was seen in this study -> http://anabolicminds.com/forum/supplement-science/262457-chlorophytum-borivilianum-velvet.html , this increase may lead to improved sleep quality as well as many other potential benefits from increased GH levels.

I don't even get an honorable mention or a product call out?

 

[USPlabsRep]

Do you know the individual dose for Chlorophytum Borivilianum and Velvet Bean to equal the 2250 mg?

PowerFULL is the product.

 

[koi1214]

PowerFULL is the product.

Thank you.

 

[JudoJosh]

So 9 time over their original level of GH secretion?

maybe this will help better


pre ingestion value was 0.18 ± 0.04 ng · mL−1
post ingestion value was 1.76 ± 0.69 ng · mL−1

 

[JudoJosh]

Do you know the individual dose for Chlorophytum Borivilianum and Velvet Bean to equal the 2250 mg?

via FT

The investigational dietary supplement used in this investigation contained a proprietary blend of Chlorophytum borivilianum (root) and Velvet bean (bean). Although the concentration of active ingredients in each capsule was identical, two different excipients were used in manufacturing

 

[JudoJosh]

I don't even get an honorable mention or a product call out?

was trying to avoid the whole, funded by supplement company skepticism, in hopes of forum members viewing the study more objectively

 

[thebigt]

what length of time could i safely use these ingredients? any ancillaries you recommend for both getting best results and or running long term?

 

[USPlabsRep]

was trying to avoid the whole, funded by supplement company skepticism, in hopes of forum members viewing the study more objectively

Study design and it being University studied solves that...

 

[thebigt]

Study design and it being University studied solves that...

lol........i am keeping my mouth shut!!!!:newangel:

 

[USPlabsRep]

lol........i am keeping my mouth shut!!!!:newangel:

why is that funny?

Its funny that a company spends money to study there products (we have over 12 University studies, several animal and clinicals.)

How much has iron champ usa done?

 

[thebigt]

why is that funny?

Its funny that a company spends money to study there products (we have over 12 University studies, several animal and clinicals.)

How much has iron champ usa done?

nothing personal, my man....my feelings towards study's are well documented....i am having a good day and don't want to go there!!!

 

[Grayson]

PowerFULL is the product.

Can you please post or direct me to the graphs in this study. I'm on my phone now, so it's a little difficult.

 

[koi1214]

Study design and it being University studied solves that...

Can you please post or direct me to the graphs in this study. I'm on my phone now, so it's a little difficult.

USPlabsRep or JudoJosh Who funded these studies and can you post the link/links?

 

[JudoJosh]

Can you please post or direct me to the graphs in this study. I'm on my phone now, so it's a little difficult.

Here you go

"Serum growth hormone of 13 exercise-trained men before and during the two-hour period after oral intake of supplement. Pooled values for Tests 1 and 2 are presented in panel A. Time (P = 0.10); 60 min (P = 0.04), 80 min (P = 0.02), and 100 min (P = 0.05) greater than Pre. Independent values for Test 1 and Test 2 are presented in panel B. Test × time (P = 0.39). Test (P = 0.02). Time (P = 0.01); 60 min (P = 0.01), 80 min (P = 0.004), and 100 min (P = 0.02) greater than Pre."

"Serum growth hormone AUC of 15 exercise-trained men during the two-hour period after oral intake of supplement. Pooled values for Tests 1 and 2 are presented in panel A. Subject 2 (Pre GH value = 6.3 ng · mL−1) and Subject 8 (Pre GH value = 1.8 ng · mL−1) were excluded from the time analysis due to high Pre GH levels. All other subjects had Pre GH levels ≤ 0.5 ng · mL−1 (Pre GH range: 0.02–0.5 ng · mL−1). Independent values for Test 1 and Test 2 are presented in panel B."

 

[JudoJosh]

USPlabsRep or JudoJosh Who funded these studies and can you post the link/links?

"Funding for this work was provided in part by USPlabs, LLC and the University of Memphis."

 

[Nyrin]

The significance of this is highly dubious to me. Given how incredibly pulsatile GH release is, it's not shocking that anything that induces a pulse, however minor, will produce dramatic comparative results.

Going from 0.18 ng/mL to 1.78 ng/mL is like going from a droplet to a trickle. For perspective, the peak during plain old, boring sleep is often accompanied by levels in excess of 50 ng/mL -- the few daytime surges will regularly go above 5 ng/mL or even much higher.

I'd be much more interested to see study results on the effect of the peaks of pulsatile GH release that actually matter rather than basal levels. Given the arguments that there are around the importance of a refractory period for GH sensitivity, elevating basal levels might actually be counterproductive.

 

[USPlabsRep]

The significance of this is highly dubious to me. Given how incredibly pulsatile GH release is, it's not shocking that anything that induces a pulse, however minor, will produce dramatic comparative results.

Going from 0.18 ng/mL to 1.78 ng/mL is like going from a droplet to a trickle. For perspective, the peak during plain old, boring sleep is often accompanied by levels in excess of 50 ng/mL -- the few daytime surges will regularly go above 5 ng/mL or even much higher.

I'd be much more interested to see study results on the effect of the peaks of pulsatile GH release that actually matter rather than basal levels. Given the arguments that there are around the importance of a refractory period for GH sensitivity, elevating basal levels might actually be counterproductive.

could you reference your arguments that its insignificant? How about just the "droplet" part? Obviously, Sleep is not a very "boring" time for GH release.

why would it be counterproductive?

 

[Nyrin]

could you reference your arguments that its insignificant? How about just the "droplet" part? Obviously, Sleep is not a very "boring" time for GH release.

why would it be counterproductive?

Growth hormone levels during sleep: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC297368/ -- sleep onset initiates somatotropin pulses in the 13-72 ng/mL range that last a few hours.

If we were just looking at an AUC argument, 2 hours of 50 ng/mL (a normal, unaugmented sleep-related GH pulse) would drastically overshadow a potential small increase in baseline levels.

As it is, keeping it in pulses rather than an elevated baseline is likely a very good thing: I can't find studies at the moment, but very common discussion in the use of GHRH compounds centers around the concept of "HGH bleed," or near-constant secretion of somtatotropin. The argument of whether or not to use the DAC version of CJC-1295 (mod grf 1-29) often centers around this, and the informed perspective seems to always be "don't use the DAC," or "keep it pulsatile." Chronically elevated levels appear to increase resistance to the desired effects while still contributing to undesirable ones, e.g. acromegaly and organ enlargement. Not that this is terribly relevant when talking about the difference between 0.18 ng/mL and 1.78 ng/mL levels, of course -- it's more that there's not really any good reason to want to elevate baseline levels to begin with.

Now, I'm not saying that chlorophytum isn't useful. It's entirely plausible that along with its studied implications on sleep it also has very real and desirable effects on the size and/or duration of pulsatile GH release. That is the kind of effect we'd really like to see.

 

[fightbackhxc]

Nevertheless good to see a study out. I've been taking growth factor xt for awhile now and love it

 

[kissdadookie]

it's more that there's not really any good reason to want to elevate baseline levels to begin with./QUOTE]

I thought that it's highly anabolic when you start hitting supraphysiological doses (exogenous source obviously to reach such levels)?

 

[alwaysfirst]

Are you guys using Powerfull or any other OTC "hgh supplement" ?

 

[fightbackhxc]

Are you guys using Powerfull or any other OTC "hgh supplement" ?

Growth factor xt

 

[alwaysfirst]

Growth factor xt

I unfortunately never got the sleep I was hoping for with that one...

 

[fightbackhxc]

I unfortunately never got the sleep I was hoping for with that one...

It knocks me out every night. I didn't even hear my alarm going off this morning. We're you taking it on an empty stomach?

 

[USPlabsRep]

Growth hormone levels during sleep: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC297368/ -- sleep onset initiates somatotropin pulses in the 13-72 ng/mL range that last a few hours.

If we were just looking at an AUC argument, 2 hours of 50 ng/mL (a normal, unaugmented sleep-related GH pulse) would drastically overshadow a potential small increase in baseline levels.

As it is, keeping it in pulses rather than an elevated baseline is likely a very good thing: I can't find studies at the moment, but very common discussion in the use of GHRH compounds centers around the concept of "HGH bleed," or near-constant secretion of somtatotropin. The argument of whether or not to use the DAC version of CJC-1295 (mod grf 1-29) often centers around this, and the informed perspective seems to always be "don't use the DAC," or "keep it pulsatile." Chronically elevated levels appear to increase resistance to the desired effects while still contributing to undesirable ones, e.g. acromegaly and organ enlargement. Not that this is terribly relevant when talking about the difference between 0.18 ng/mL and 1.78 ng/mL levels, of course -- it's more that there's not really any good reason to want to elevate baseline levels to begin with.

Now, I'm not saying that chlorophytum isn't useful. It's entirely plausible that along with its studied implications on sleep it also has very real and desirable effects on the size and/or duration of pulsatile GH release. That is the kind of effect we'd really like to see.

I'm not following. Are you comparing exogenous elevation with endogenous elevation of GH and that no matter the circumstance keeping GH at baseline is best?

 

[alwaysfirst]

It knocks me out every night. I didn't even hear my alarm going off this morning. We're you taking it on an empty stomach?

Yes, had a shake 1-2 hours before. Had high hopes for it also

 

[fightbackhxc]

Yes, had a shake 1-2 hours before. Had high hopes for it also

If you try again a similar product again take your GH product 1 hour before your shake. I find this to be best.

 

[mr.cooper69]

it's more that there's not really any good reason to want to elevate baseline levels to begin with./QUOTE]

I thought that it's highly anabolic when you start hitting supraphysiological doses (exogenous source obviously to reach such levels)?

GH isn't really anabolic, it's main utility for body composition is fat loss. But really, the reason to use a natural GH booster is for the health benefits of optimized GH levels: improved sleep, improved recovery, injury healing, healthier skin, etc.

Pulses are considered more powerful stimuli than a "bleed," but there is still decent evidence that peptides like CJC w/ DAC (which creates a GH bleed) still work for achieving the goals of elevated GH. What you essentially get is an elevated baseline, and then the natural pulses on top of that, so your peak pulse is still higher on the net

 

[koi1214]

GH isn't really anabolic, it's main utility for body composition is fat loss. But really, the reason to use a natural GH booster is for the health benefits of optimized GH levels: improved sleep, improved recovery, injury healing, healthier skin, etc.

Pulses are considered more powerful stimuli than a "bleed," but there is still decent evidence that peptides like CJC w/ DAC (which creates a GH bleed) still work for achieving the goals of elevated GH. What you essentially get is an elevated baseline, and then the natural pulses on top of that, so your peak pulse is still higher on the net

mr.cooper69 your thoughts on MK-677 and also peptides vs MK-677.

 

[SuppWithThat]

The thing to keep in mind when looking at potential "GH-boosters" is how fast GH levels normalize after the initial rise. Alpha GPC and Arginine are a couple ingredients that are often touted to increase GH but practical application is limited due to rapid normalization (i.e. GH levels return to normal within an hour or two).

The study you reference noted no significant differences between pre-ingestion and 120 min post-ingestion, indicating that normalization may occur somewhere between 100 and 120min post ingestion. So the question is: How frequently would you need to consume Chlorophytum Borivilianum and Velvet Bean in order to experience a sustained increase in GH? More studies are definitely needed here.

 

[mr.cooper69]

mr.cooper69 your thoughts on MK-677 and also peptides vs MK-677.

Mk-677 is certainly effective and is the preferred choice to peptides for treating GH deficiency, though neither are approved as of now

The thing to keep in mind when looking at potential "GH-boosters" is how fast GH levels normalize after the initial rise. Alpha GPC and Arginine are a couple ingredients that are often touted to increase GH but practical application is limited due to rapid normalization (i.e. GH levels return to normal within an hour or two).

The study you reference noted no significant differences between pre-ingestion and 120 min post-ingestion, indicating that normalization may occur somewhere between 100 and 120min post ingestion. So the question is: How frequently would you need to consume Chlorophytum Borivilianum and Velvet Bean in order to experience a sustained increase in GH? More studies are definitely needed here.

You mention the length of time as if it is an issue. Data in treating GH deficiency shows that we want no longer than a 3 hour peak; anything more renders the GH useless. We do NOT want a sustained peak. Peptides used for GH replacement generally peak at 30 minutes and induce elevation for 3 hours maximum. Just one dose of these daily is sufficient for skin conditions. So in summary, we only care about the magnitude of the GH pulse, not the length.

 

[SuppWithThat]

Mk-677 is certainly effective and is the preferred choice to peptides for treating GH deficiency, though neither are approved as of now



You mention the length of time as if it is an issue. Data in treating GH deficiency shows that we want no longer than a 3 hour peak; anything more renders the GH useless. We do NOT want a sustained peak. Peptides used for GH replacement generally peak at 30 minutes and induce elevation for 3 hours maximum. Just one dose of these daily is sufficient for skin conditions. So in summary, we only care about the magnitude of the GH pulse, not the length.

Interesting. We certainly don't claim to be experts on GH-boosters. If magnitude is all that matters then Alpha GPC should actually be quite effective. Short but significant increase in GH at 1000mg acute dosage.

 

[kisaj]

What is the dose that has been effective with Alpha GPC regarding GH? I am not sure if I have found that info in the past. I've taken 600mg daily for the last 10 years for cognitive purposes only.

 

[SuppWithThat]

What is the dose that has been effective with Alpha GPC regarding GH? I am not sure if I have found that info in the past. I've taken 600mg daily for the last 10 years for cognitive purposes only.

600mg has been shown to significantly increase exercise-induced (peak) GH release and 1000mg has been shown to increase circulating (plasma) GH levels without exercise. So that 600mg dose your taking is within the effective range, although it would probably depend on when you took your Alpha GPC in relation to exercise.

 

[kisaj]

600mg has been shown to significantly increase exercise-induced (peak) GH release and 1000mg has been shown to increase circulating (plasma) GH levels without exercise. So that 600mg dose your taking is within the effective range, although it would probably depend on when you took your Alpha GPC in relation to exercise.

Right, I assumed that timing was a big portion, but wasn't sure the amount as we know Alpha GPC is expensive and I wasn't sure how beneficial it would be for GH purposes at higher doses.

 

[kissdadookie]

Right, I assumed that timing was a big portion, but wasn't sure the amount as we know Alpha GPC is expensive and I wasn't sure how beneficial it would be for GH purposes at higher doses.

Define expensive, because you can get 50 grams of it for around $20. That doesn't sound expensive to me.

 

[kisaj]

Well, it is one of the products I buy capped already and generally around $30mo at 600mg daily. My luck with bulk suppliers of Alpha GPC seems to be less than stellar.

50 grams for $20 is very cheap.

 

[kissdadookie]

Well, it is one of the products I buy capped already and generally around $30mo at 600mg daily. My luck with bulk suppliers of Alpha GPC seems to be less than stellar.

50 grams for $20 is very cheap.

Technically it's like $23 dollars, and that's for Alphasize bulk powder.

 

[kisaj]

whoa, whoa, whoa, you never mentioned that extra $3. This changes everything.

 

[kisaj]

It would be nice if they did additional studies on it. Related to fitness, they always refer back to the same tiny 7 person study.

 

[Dragoninho]

Second this.

I must say that I'm impressed with Growth factor XT.
Just after a week or so I look hard and shredded.
And I had no expectations what so ever on it. For me it was a hit.

 

[fightbackhxc]

Second this.

I must say that I'm impressed with Growth factor XT.
Just after a week or so I look hard and shredded.
And I had no expectations what so ever on it. For me it was a hit.

Thanks, try stacking it with inhibit-e next time. It's awesome.

 

[alwaysfirst]

600mg has been shown to significantly increase exercise-induced (peak) GH release and 1000mg has been shown to increase circulating (plasma) GH levels without exercise. So that 600mg dose your taking is within the effective range, although it would probably depend on when you took your Alpha GPC in relation to exercise.

When would be the optimal time to dose Alpha GPC to get most out of it?

 

[mr.cooper69]

Preworkout fasted

 

[Synapsin]

Define expensive, because you can get 50 grams of it for around $20. That doesn't sound expensive to me.

Have you ever used that source?