Yet another reason for your omega's (Lupus)

  1. Yet another reason for your omega's (Lupus)

    <DIV class=storyheadline>Obviously this study is talking about lupus, but we can see the benefits from Omega acids yet again, drink your flax (or fish) oil damnit!</DIV>

    <DIV class=storyheadline>&nbsp;</DIV>

    <DIV class=storyheadline>Fish Oil May Ease Symptoms of Lupus: Study</DIV>

    <DIV class=storyheadline>&nbsp;</DIV>

    <DIV class=storyheadline>LONDON (Reuters Health) - People with the immune disorder lupus might be able to reduce their symptoms with the fatty acids found in fish such as tuna and salmon, researchers in Northern Ireland said on Tuesday.

    In what the scientists call the largest study of its kind, Dr. Emeir Duffy and colleagues studied the effect of fish oil supplements in 52 patients with active lupus over six months.

    All the participants who took the fish oil saw improvements in quality of life, inflammation and fatigue, which is the most debilitating symptom of lupus, said Duffy, a biomedical scientist from the University of Ulster. "Some found it fantastic, and they went from being severely affected in their daily life to actually joining the gym and having a huge difference in what they could do," she told Reuters Health. "Others saw a mild improvement, being able to go out and do the shopping which is a big bonus to some people who can't even leave the house." Systemic lupus erythematosus--commonly referred to as lupus--is a disorder in which the immune system attacks healthy tissue throughout the body, causing painful or swollen joints, unexplained fever, skin rashes, kidney problems, cardiovascular complications and extreme fatigue. Lupus is a complex disease and the exact cause is unclear. There is currently no effective treatment to stop its progression, although steroids and other drugs are used to manage symptoms. Recently, researchers have been looking at managing the disease through diet. The omega-3 fatty acids found in fish oils and some other foods have raised particular interest because they are thought to fight inflammation and affect immune function. "We found that some patients taking steroids and taking the fish oils actually reduced their dose (of steroids) toward the end of the study," Duffy said. Participants took either fish-oil supplements three times per day, a copper supplement, copper plus fish oil or a placebo. The copper was of no benefit, Duffy's team found. She said people with lupus could get the benefits seen in her study by increasing their intake of fatty fish such as mackerel, lake trout, herring, sardines, tuna and salmon.
    Last edited by jweave23; 03-11-2003 at 05:50 PM.

  2. Omega-3 Fatty acids in inflammation and autoimmune diseases.

    Simopoulos AP.

    The Center for Genetics, Nutrition and Health, Washington, D.C.

    Among the fatty acids, it is the omega-3 polyunsaturated fatty acids (PUFA) which possess the most potent immunomodulatory activities, and among the omega-3 PUFA, those from fish oil-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)-are more biologically potent than alpha-linolenic acid (ALA). Some of the effects of omega-3 PUFA are brought about by modulation of the amount and types of eicosanoids made, and other effects are elicited by eicosanoid-independent mechanisms, including actions upon intracellular signaling pathways, transcription factor activity and gene expression. Animal experiments and clinical intervention studies indicate that omega-3 fatty acids have anti-inflammatory properties and, therefore, might be useful in the management of inflammatory and autoimmune diseases. Coronary heart disease, major depression, aging and cancer are characterized by an increased level of interleukin 1 (IL-1), a proinflammatory cytokine. Similarly, arthritis, Crohn's disease, ulcerative colitis and lupus erythematosis are autoimmune diseases characterized by a high level of IL-1 and the proinflammatory leukotriene LTB(4) produced by omega-6 fatty acids. There have been a number of clinical trials assessing the benefits of dietary supplementation with fish oils in several inflammatory and autoimmune diseases in humans, including rheumatoid arthritis, Crohn's disease, ulcerative colitis, psoriasis, lupus erythematosus, multiple sclerosis and migraine headaches. Many of the placebo-controlled trials of fish oil in chronic inflammatory diseases reveal significant benefit, including decreased disease activity and a lowered use of anti-inflammatory drugs.

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