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  1. The DominATP ingredients are very easy and cheap to buy in bulk; doing so once sets you up for the year. That's basically what I've done.


  2. The Supersaponins never did anything for me at all. I like Pslin though, bulk modern bcaa too.
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  3. Quote Originally Posted by T-Bone View Post
    The Supersaponins never did anything for me at all. I like Pslin though, bulk modern bcaa too.
    How did you dose SuperSaponins?
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  4. Very excited for reformulated p slin.

    As for anabolic pump- I am a year round user.. 1- Do u think that is counterproductive?

    2- can 2 caps be taken prior to a cheat meal, similar to advice (which worked very well) regarding slin sane.. Took 2 prior to carb heavy cheat n experienced very little bloat next day... Can 2 ap be taken or is that non advisable?

    3- is 30 minutes wait better than 15? Some knowledgable members have suggested 15 minutes isn't enough time to get desired effects.

    Thank you! And thanks again for the c20 promo!

  5. The USP GDAs are the only ones I have used that really hit hard...pharmaceutical grade was no exaggeration
    HIGH VOLUME - Supreme Stim-Free Nitric Oxide Matrix
    SELECT Protein
    - Ultra-Premium Blend
    ALPHAMINE - Thermogenics...Redefined

  6. Quote Originally Posted by nattydisaster
    The USP GDAs are the only ones I have used that really hit hard...pharmaceutical grade was no exaggeration
    What does "pharmaceutical grade" even mean? I've always believed (still do) it's just marketing. Any insight?
    Always willing to learn :D

  7. It means so strong its similar or comparable Rx.

    Pharmaceutical grade in its quality and its effectiveness.

    Obviously there is no pharmaceutical BCAAs or GDAs, but the 8:1:1 BCAAs and PSlin and Anabolic Pump are effective to the point if there was such thing as an Rx BCAA or GDA, they would be it
    HIGH VOLUME - Supreme Stim-Free Nitric Oxide Matrix
    SELECT Protein
    - Ultra-Premium Blend
    ALPHAMINE - Thermogenics...Redefined

  8. Quote Originally Posted by chedapalooza View Post
    Very excited for reformulated p slin.

    As for anabolic pump- I am a year round user.. 1- Do u think that is counterproductive?

    2- can 2 caps be taken prior to a cheat meal, similar to advice (which worked very well) regarding slin sane.. Took 2 prior to carb heavy cheat n experienced very little bloat next day... Can 2 ap be taken or is that non advisable?

    3- is 30 minutes wait better than 15? Some knowledgable members have suggested 15 minutes isn't enough time to get desired effects.

    Thank you! And thanks again for the c20 promo!
    1) Many users consume Anabolic Pump year round, as no GLUT-4-response downgrading occurs and effectiveness is not compromised, as a consequence. Yet, cycling is still appropriate. More specifically, chronic (in the neutral sense of continuous use for an extended period of time) users can take a 2-4 week break after an on-cycle of up to 16 weeks.
    2) You can take two capsules before a relatively large (say about 85g-120g) carbohydrate meal.
    3)There are no hard-and-fast rules in terms of timing, as this depends a lot on the specific individual. Consider the timing option as a window or range, rather than a fixed point. Some are fine with 15 minutes, some others report best results with 20 minutes, while some prefer 30 minutes or a little longer as their perfect timing. Personal experimentation is key for Anabolic-Pump-type class of compounds. Personally, I prefer to eat 20 minutes post-Anabolic Pump/P-Slin consumption.

    Please let me know if anything else is unclear.

    Thank you for participating in the USPlabs/PES promotion, and thank you for your continued support!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  9. Quote Originally Posted by nattydisaster View Post
    It means so strong its similar or comparable Rx.

    Pharmaceutical grade in its quality and its effectiveness...
    Spot on!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  10. Quote Originally Posted by nattydisaster View Post
    The USP GDAs are the only ones I have used that really hit hard...pharmaceutical grade was no exaggeration
    Awesome feedback. Thank you!
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.
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  11. Thanks for the detailed response, greatly appreciated.. Truly glad to have you guys back on the boards.

  12. Quote Originally Posted by chedapalooza View Post
    Thanks for the detailed response, greatly appreciated.. Truly glad to have you guys back on the boards.
    Thank you! We are always glad to help whenever we can.
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  13. Quote Originally Posted by strategicmove View Post
    We are currently working on an improved Bulk P-Slin. We will let you know when it is ready.
    will it be in those little pellets like what was inside the capped version or powder?
    :blindfold:

  14. Quote Originally Posted by monstermash

    will it be in those little pellets like what was inside the capped version or powder?
    I hope it's capped like anabolic pump. Just so convenient. I use 5-7 supps plus 5-7 staples daily plus protein n bcaa powders so I'm already lugging two shakers n tubs.. Pills please

  15. Quote Originally Posted by monstermash View Post
    will it be in those little pellets like what was inside the capped version or powder?
    Powder, like the previous version, and to maintain the low-price strategy.
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  16. Quote Originally Posted by strategicmove
    Powder, like the previous version, and to maintain the low-price strategy.
    Ok, just trying to guess the way you're going to improve it without raising the price all that much. Any hints?
    :blindfold:

  17. Quote Originally Posted by chedapalooza

    I hope it's capped like anabolic pump. Just so convenient. I use 5-7 supps plus 5-7 staples daily plus protein n bcaa powders so I'm already lugging two shakers n tubs.. Pills please
    I have two boxes of the capped version in the blister packs if you have anything to trade.
    :blindfold:

  18. Quote Originally Posted by monstermash View Post
    Ok, just trying to guess the way you're going to improve it without raising the price all that much. Any hints?
    Higher concentration of the actives.
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  19. Quote Originally Posted by strategicmove
    Higher concentration of the actives.
    I have only used the capped version of p slin but damn. I got so pumped and full and vascular on it.. Unfortunately, anabolic pump seems to keep me from actually filling out, rather I always am able to stay lean and no matter how i eat or train, my muscles stay elongated and never truly bulk up when using pump. I have notices on all other gdas I've used, that I do fill In and grow easier, like the case with p slin. Any ideas why ap may keep me from really filling out?

  20. Quote Originally Posted by chedapalooza View Post
    I have only used the capped version of p slin but damn. I got so pumped and full and vascular on it.. Unfortunately, anabolic pump seems to keep me from actually filling out, rather I always am able to stay lean and no matter how i eat or train, my muscles stay elongated and never truly bulk up when using pump. I have notices on all other gdas I've used, that I do fill In and grow easier, like the case with p slin. Any ideas why ap may keep me from really filling out?
    Most glucose-disposal agents indiscriminately shuttle glucose into skeletal-muscle and adipose cells alike, suggesting that they are not necessarily lipolytic (fat-burning). Anabolic Pump, however, is one of the few agents that preferentially channels glucose into skeletal muscle cells at the expense of fat cells, promoting noticeable fat-loss effects, in addition to the classic glucose-disposal role. It achieves this via a number of molecular mechanisms that include up-regulation of the expression of the enzyme 5'-adenosine monophosphate-activated protein kinase (AMPK) [leading to the inhibition of the synthesis or production of fatty acids, as well as increased beta oxidation of fatty acids], mitogen-activated protein kinase (MAPK), p38 MAPK, peroxisome proliferator-activated receptor alpha (PPARa), uncoupling protein-2 (UCP-2), and hepatic (liver) nuclear factor 4 alpha (HNF4a). Furthermore, it down-regulates the expression of peroxisome proliferator-activated receptor gamma (PPARg), PPARg cofactors, as well as resistin, acts as a potent competitive inhibitor of the human protein tyrosine phosphatase 1B (h-PTB1B, an inhibitor of insulin signaling), blocks adipogenesis (new-fat formation) in fat cells [via inhibition of PPARg and C/ERB alpha, and by activating PPARa], reduces GLUT4 mRNA expression in fat cells, and lowers the expression of multiple lipogenic and adipogenic genes in adipocytes (fat cells). So, Anabolic Pump does not simply dispose glucose indiscriminately in muscle and fat cells alike, but supports fat-loss via different pathways. Consequently, you might not feel as full on Anabolic Pump as on other GDAs because, with Anabolic Pump, you should also see fat loss, while some other GDAs might induce weight gain via carbohydrate overspills.
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  21. Quote Originally Posted by strategicmove
    Most glucose-disposal agents indiscriminately shuttle glucose into skeletal-muscle and adipose cells alike, suggesting that they are not necessarily lipolytic (fat-burning). Anabolic Pump, however, is one of the few agents that preferentially channels glucose into skeletal muscle cells at the expense of fat cells, promoting noticeable fat-loss effects, in addition to the classic glucose-disposal role. It achieves this via a number of molecular mechanisms that include up-regulation of the expression of the enzyme 5'-adenosine monophosphate-activated protein kinase (AMPK) [leading to the inhibition of the synthesis or production of fatty acids, as well as increased beta oxidation of fatty acids], mitogen-activated protein kinase (MAPK), p38 MAPK, peroxisome proliferator-activated receptor alpha (PPARa), uncoupling protein-2 (UCP-2), and hepatic (liver) nuclear factor 4 alpha (HNF4a). Furthermore, it down-regulates the expression of peroxisome proliferator-activated receptor gamma (PPARg), PPARg cofactors, as well as resistin, acts as a potent competitive inhibitor of the human protein tyrosine phosphatase 1B (h-PTB1B, an inhibitor of insulin signaling), blocks adipogenesis (new-fat formation) in fat cells [via inhibition of PPARg and C/ERB alpha, and by activating PPARa], reduces GLUT4 mRNA expression in fat cells, and lowers the expression of multiple lipogenic and adipogenic genes in adipocytes (fat cells). So, Anabolic Pump does not simply dispose glucose indiscriminately in muscle and fat cells alike, but supports fat-loss via different pathways. Consequently, you might not feel as full on Anabolic Pump as on other GDAs because, with Anabolic Pump, you should also see fat loss, while some other GDAs might induce weight gain via carbohydrate overspills.
    Thanks. What about the talk of berberine (phellodendren) blunting protein synthesis. I'm talking decreased muscle size, not mass in general. I understand other gda's can cause fat gain from carb spillover. But I notice larger muscles when not on ap :/ I still use it tho bc it is the best at keeping me lean which is my first n primary goal...

  22. Quote Originally Posted by chedapalooza View Post
    Thanks. What about the talk of berberine (phellodendren) blunting protein synthesis. I'm talking decreased muscle size, not mass in general. I understand other gda's can cause fat gain from carb spillover. But I notice larger muscles when not on ap :/ I still use it tho bc it is the best at keeping me lean which is my first n primary goal...
    The inhibitory effect on protein synthesis is transient, and does not preclude Anabolic Pump from regulating glucose disposal and lipid metabolism. Someone asked a similar question at USPlabsdirect(dot)com, and I gave the following detailed response, if it interests you:

    Before responding directly to the implied impact of berberine's activation of AMPK, and AMPK's subsequent inhibitory impact of protein synthesis on the effectiveness of Anabolic Pump, it is useful to sketch a quick review of the workings of Anabolic Pump. As is well known, Anabolic Pump is made up of Phellodendron (bark) and Crepe Myrtle (Lagerstroemia speciosa)

    The Phellodendron in Anabolic Pump is specifically extracted for its main bioactive constituent, berberine, an isoquinoline derivative alkaloid with a broad range of pharmacological effects. In particular, berberine induces a variety of effects that include insulin-sensitization, glucose-disposal, anti-hyperglycemic, anti-adipogenic, and anti-diabetic benefits, without altering native insulin levels. Furthermore, Anabolic Pump via berberine*activates the enzymes 5'-adenosine monophosphate-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK), p38 MAPK, peroxisome proliferator-activated receptor alpha (PPARa), uncoupling protein-2 (UCP-2), as well as hepatic nuclear factor 4 alpha (HNF4a). On the other hand, berberine suppresses the expression of peroxisome proliferator-activated receptor gamma (PPARg), ultimately leading to beneficial glucose and lipid metabolism.

    An important mechanism for berberine's plasma glucose-lowering effect is via acting as a powerful competitive inhibitor of the human protein tyrosine phosphatase 1B (h-PTB1B). A negative regulator of insulin transduction, PTB1B levels are high in insulin-dysfunctional states. Put differently, PTB1B suppresses insulin action and insulin sensitivity in skeletal muscle and fat cells. Hence, by inhibiting h-PTB1B, berberine restores cellular insulin sensitivity and lowers plasma glucose levels.

    Regarding suppression of lipid metabolism, berberine achieves this via blocking of adipogenesis in fat cells by inhibiting PPARg and C/ERB alpha, and by stimulating PPARa activity, while suppressing the expression of GLUT4 mRNA activity in fat cells and reducing the expression of multiple lipogenic and adipogenic genes in adipocytes.

    The other compound in Anabolic Pump is Banaba, Crepe Myrtle, or Lagerstroemia speciosa, and contains bioactive ingredients known as corosolic acid and tannic acid (or tannins). Gallotannins constitute the main components of tannic acid. An ellagitannin, Lagerstroemin is another tannin found in Lagerstroemia speciosa. This is relevant, as the Banaba in Anabolic Pump is extracted for corosolic acid and tannins that combine to deliver profound effects such as glucose-regulation and anti-diabetic activity.

    A key biochemical pathway for the action of corosolic acid and its related tannins is the glucose transport-4 (GLUT-4) protein gene. Glucose transport proteins shuttle glucose from the blood into cells. A specific glucose transporter protein, GLUT-4, found in skeletal muscle, fat, and cardiac (heart) cells, transports glucose from the blood into these cells. Usually, GLUT-4 resides deep within the cell, but can be translocated to the surface of the cell by insulin, exercise, or by corosolic acid/tannins. The more GLUT-4 cells are recruited to the cell surface, the greater the amount of glucose clearance that occurs. It has been shown in clinical trials that corosolic acid and its related tannins can cause the translocation of GLUT-4 proteins from deep with the cell to the cell membrane to trigger glucose disposal, completely independent of insulin. The consequent reduction in the levels of circulating glucose promotes reduced adipogenesis. Furthermore, in clinical trials, corosolic acid and its related tannins have been shown to down-regulate the expression of PPARg and not only suppressed the expression of pre-adipocytes, but also suppressed the differentiation of pre-adipocytes into mature adipocytes, while stimulating efficient glucose uptake, leading to significantly lower fasting and post-prandial (after-meal) blood glucose levels.

    This description of the molecular mechanisms recruited by Anabolic Pump suggests that several such mechanisms are in simultaneous play, ensuring that the benefits from Anabolic Pump remain robust under several physiological scenarios.

    Now to the article you referred to. The authors reported that berberine via stimulation of AMPK led to mTOR complex-1 (TORC1) inhibition by way of the phosphorylation of raptor (a protein involved in mTOR signaling) ultimately leading to reduced protein synthesis and enhanced protein degradation in normal and diabetic rodent muscles, as well as an enhanced downstream expression of the E3 ubiquitin ligase, atrogin-1, associated with the ubiquitin-proteasome pathway of muscle degradation. Furthermore, they reported that enhanced mitochondrial biogenesis via peroxisome proliferator-activated receptor gamma co-activator-1-alpha [PGC-1a] expression blunted the berberine-induced muscle protein-synthetic alterations. According to the authors: "We recognize that our findings from experiments utilizing mice or cultured cells may not reflect events occurring in patients with type 2 diabetes. Reports of protein turn-over in diabetic or insulin-resistant patients find no muscle wasting unless the patients are elderly or sedentary. Even though obese patients with type 2 diabetes were shown to exhibit some impairment in ATP production, it has also been found that intensive insulin therapy did not change leucine kinetics when compared with results achieved with conventional insulin therapy. However, our results do indicate that anti-diabetes drugs can cause unexpected consequences, including changes in protein metabolism" [p. 1888].

    Quite apart from the fact that their study was a rodent trial with the usual rodent-to-human-dosage-conversion issues, or the usual extrapolation problems from such trials to human results, berberine's activation of AMPK, and consequently, AMPK's suppression of protein synthesis are not controversial. As is well known, the mammalian 5' adenosine monophosphate-activated protein kinase (AMPK) is the downstream component of a crucial protein kinase cascade of central importance in the regulation of energy homeostasis (balance) conserved in all eukaryotic cells. AMPK is a phylogenetically/evolutionarily conserved serine/threonine protein kinase and is activated in response to an increase in the adenosine monophosphate (AMP): adenosine triphosphate (ATP) ratio. AMPK exists as a heterotrimeric (contains three parts that are different from one another) complex with a catalytic alpha subunit and regulatory beta- and gamma-subunits. AMPK is activated in response to metabolic stressors such as exercise/muscle contraction, hypoxia, hypoglycemia, ischemia, oxidative stress, and chemical interventions (such as berberine), with the goal of cellular energy restoration.

    Binding of AMP to the gamma-subunit leads to AMPK activation via phosphorylation at threonine 172 (Thr-172) on the alpha-subunit by the upstream kinase, LKB-1. The Ca(2+)/calmodulin-dependent and AMP-independent pathway can activate AMPK in certain cells such as neurons, endothelial cells, and lymphocytes, in a process involving phosphorylation by an alternate upstream protein kinase kinase-beta, CaMKKbeta. [Phosphorylation is the addition of phosphate to a protein, glucose, or other organic molecules or compounds. Phosphorylation is executed through the action of enzymes referred to as phosphotransferases or kinases].

    Upon activation, AMPK triggers a set of chemical reactions geared at re-establishing cellular energy homeostasis. Consequently, ATP-consuming (anabolic) processes such as protein synthesis, fatty acid synthesis (lipogenesis), biosynthesis, cell-growth, and proliferation, are switched-off, while ATP-generating (catabolic) processes such as hepatic glycolysis and fatty acid oxidation, as well as the inhibition of the production of cholesterol and triglycerides are switched-on, both by short-term effect on phosphorylation of regulatory proteins and by long-term effect on gene expression. AMPK can also be modulated by hormones. In particular, in peripheral tissues such as muscles and liver, leptin and adiponectin activate AMPK. In the hypothalamus, leptin and adiponectin, both hormones that suppress feeding, inhibit AMPK, while ghrelin, a hormone that boosts food intake, activates AMPK.
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  23. Continued...


    Berberine potently activates AMPK in skeletal muscle, L6 myotubes, adipose tissue, and in hepatocytes, leading to the suppression of protein synthesis and lipid synthesis as well as boosts in fatty acid oxidation and glucose uptake. This activation of AMPK is due to berberine's inhibition of the respiratory complex-1 of the mitochondria, leading to an elevation of the AMP/ATP ratio. Obviously, restoration of cellular energy homeostasis is crucial in this case, as ribosomal synthesis of proteins, for instance, is a significant consumer of cellular energy in a process that requires energy-rich aminoacyl-tRNA, mRNA and ATP/GTP. The regulation of protein synthesis occurs at several levels from mRNA and ribosomal content to the translation rate of mRNA into peptide, where translation involves the three phases, initiation, elongation, and termination. Short-term, protein synthesis regulation occurs at the translation level, with acute protein synthesis regulation modulated by several regulatory portions in the mTOR or eEF-2 kinase pathways. The mechanism of protein synthesis inhibition by AMPK depends on mTOR and eEF-2 signaling.

    As has already been outlined, berberine is not the only activator of AMPK, and consequently, not the only suppressor of protein synthesis. In particular, physical exercise, to use another example, also compromises protein synthesis, but this effect, just like the case of berberine, is transient. Muscle cells grow after physical exercise, and the use of certain interventions such as BCAA during exercise contribute to the suppression of AMPK, and reduce AMPK's suppressive impact on protein synthesis. The transient nature of the berberine-induced AMPK-inhibition of protein synthesis ensures that Anabolic Pump's functioning remains robust. Furthermore, while an important component, berberine activation of AMPK is not the only mechanism through which Anabolic Pump works. In particular, quite apart from the depression of protein-synthetic processes, Anabolic Pump still delivers benefits such as improvement in insulin sensitivity (which on its own leads to efficient uptake of macronutrients, including proteins), enhanced glucose disposal in skeletal muscle cells, anti-adipogenic and anti-diabetic effects, improvement in lipid and glucose metabolism, enhancements in lipolytic processes and optimization of lipid profiles. Furthermore, recall that AMPK activation induces an enhanced expression of the glucose transport protein-4 (GLUT-4) gene via increased binding of the transcription factor myocyte enhancer factor-2 (MEF-2) to co-factors in the GLUT-4 gene, leading to increased glucose transport, as well as enhanced glycolysis and ATP production. This increased ATP production ultimately leads to reduced AMPK activity, and consequently, lower suppression of protein synthesis. In the same connection, greater saturation of glycogen stores ensures lower expression of AMPK, and therefore, lower protein-synthetic suppression. To continue, recall that AMPK regulates protein translation via several mechanisms. For instance, via phosphorylation and activation of the eukaryotic elongation factor kinase (eEF2K), and via inhibition of the mTOR signaling pathway. As the regulation of protein synthesis by mTOR is highly sensitive to amino acid expression, AMPK was postulated to be also modulated by amino acids. As it turns out, recent research has suggested that amino acids suppress AMPK activity in an mTOR-independent mechanism, postulated to be via the stimulatory effects of amino acids on mitochondrial glutamate dehydrogenase that produce an increased tricarboxylic acid cycle flux, ultimately leading to reduced cellular AMP expression, and therefore, lower AMPK activity, and lower suppression of protein synthesis. This suggests that the protein content of a post-Anabolic Pump meal should serve to suppress AMPK action and lead to higher protein-synthetic expression.

    In conclusion, the transient effect of the suppression of protein synthesis due to berberine's activation of AMPK, coupled with the other molecular mechanisms through which the components of Anabolic Pump, namely Phellodendron and Crepe Myrtle, work ensures that Anabolic Pump still delivers its benefits enumerated earlier.
    Product Educator | USPowders
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  24. It is fantastic having such a knowledgeable member posting regularly who takes the time to post detailed answers.

    Great posts Ike.
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  25. Quote Originally Posted by bdcc View Post
    It is fantastic having such a knowledgeable member posting regularly who takes the time to post detailed answers.

    Great posts Ike.
    Thank you, B! I'm glad to help whenever I can.
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  26. man now i feel like trying out AP lol

  27. Quote Originally Posted by Bolanrox View Post
    man now i feel like trying out AP lol
    Would appreciate your feedback, should you do so. Thank you!
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  28. it will be a while - this summer most likely but if i do i will log it
  29. AnabolicMinds Site Rep
    MidwestBeast's Avatar

    AP is good. It was the first to pop my GDA cherry and allow me to feel like I could eat carbs, again. lol
    Psalm 34:10 - "The lions may grow weak and hungry, but those who seek the Lord lack no good thing."
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  30. Quote Originally Posted by Bolanrox View Post
    it will be a while - this summer most likely but if i do i will log it
    Awesome. Would be great.
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