Discovering the dosing sweet spot with Anabolic Pump, much like other supplements, is a very intuitive process; the Manual provides basic guidelines through which you realize your own perfect protocol.
This variability inevitably stems from the confluence of enzymes, energy messengers, and transcription factors AP is modulating - that is, it is a very complicated supplement!
The response (or lack thereof) is dependent on a great number of genetic markers: natural predisposition towards Insulin Insensitivity via deregulated Insulin receptor action, deregulated Akt (prominent Insulin-dependent glucose regulator), or low levels of GLUT4, unresponsiveness to AMPk mitigated anti-lipogenic action (body does not respond to AMPk regulating lipogenic transcription factors), or simply the overexpression of lipogenic transcription factors themselves (PPAR-Gamma2).
With that being said, however, AP is a very efficient and potent supplement. Once the particular method right for you has been found, it's a wonderful thing!