Sirplus Feed Back Thread...
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Here is a good perk
Department of Exercise Science, University of South Carolina, Columbia,
South Carolina, United States.
Downhill running is associated with fiber damage, inflammation,
delayed-onset muscle soreness (DOMS) and various functional deficits. Curcumin, a
constituent of the Indian spice turmeric has been investigated for its
anti-inflammatory activity and may offset some of the damage and functional deficits
associated with downhill running. This study examined the effects of curcumin on
inflammation and recovery of running performance following downhill running in
mice. Male mice were assigned to: downhill placebo (Down-Plac), downhill
curcumin (Down-Cur), uphill placebo (Up-Plac) or uphill curcumin (Up-Cur) and
run on a treadmill at 22 m/min at -14% or +14% grade, for 150 min. At 48h or
72h after the up/downhill run, mice (Exp-1) underwent a treadmill performance
run to fatigue. Another subset of mice was placed in activity wheel-cages
following the up/downhill run (Exp-2) and their voluntary activity (distance,
time & peakspeed) was recorded. Additional mice (Exp-3) were sacrificed at 24h
and 48h following the up/downhill run and the soleus muscle was harvested for
analysis of inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha), and plasma
was collected for creatine kinase analysis. Downhill running decreased both
treadmill run time to fatigue (48h and 72h) and voluntary wheel activity
(24h) (P<0.05), and curcumin feedings offset these effects on running
performance. Downhill running was also associated with an increase in inflammatory
cytokines (24h and 48h) and creatine kinase (24h) (P<0.05) that were blunted by
curcumin feedings. These results support the hypothesis that curcumin can
reduce inflammation and offset some of the performance deficits associated with
eccentric exercise-induced muscle damage
Department of Exercise Science, University of South Carolina, Columbia,
South Carolina, United States.
Downhill running is associated with fiber damage, inflammation,
delayed-onset muscle soreness (DOMS) and various functional deficits. Curcumin, a
constituent of the Indian spice turmeric has been investigated for its
anti-inflammatory activity and may offset some of the damage and functional deficits
associated with downhill running. This study examined the effects of curcumin on
inflammation and recovery of running performance following downhill running in
mice. Male mice were assigned to: downhill placebo (Down-Plac), downhill
curcumin (Down-Cur), uphill placebo (Up-Plac) or uphill curcumin (Up-Cur) and
run on a treadmill at 22 m/min at -14% or +14% grade, for 150 min. At 48h or
72h after the up/downhill run, mice (Exp-1) underwent a treadmill performance
run to fatigue. Another subset of mice was placed in activity wheel-cages
following the up/downhill run (Exp-2) and their voluntary activity (distance,
time & peakspeed) was recorded. Additional mice (Exp-3) were sacrificed at 24h
and 48h following the up/downhill run and the soleus muscle was harvested for
analysis of inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha), and plasma
was collected for creatine kinase analysis. Downhill running decreased both
treadmill run time to fatigue (48h and 72h) and voluntary wheel activity
(24h) (P<0.05), and curcumin feedings offset these effects on running
performance. Downhill running was also associated with an increase in inflammatory
cytokines (24h and 48h) and creatine kinase (24h) (P<0.05) that were blunted by
curcumin feedings. These results support the hypothesis that curcumin can
reduce inflammation and offset some of the performance deficits associated with
eccentric exercise-induced muscle damage
lbarber
Member
Thanks for the info USP! I will pay close attention to how I feel while on this, and see what effects I do notice! I have 3 bottles to plow through, so we'll see how things go...
Anyways, I understand you've been using it for a while now, how do you like it? I understand there may be bias in this, but I've come to trusts your posts as I've responded to your other supplements in the past...
Anyways, I understand you've been using it for a while now, how do you like it? I understand there may be bias in this, but I've come to trusts your posts as I've responded to your other supplements in the past...
saludable24
Active member
Any updates lbarber? Or anyone else for that matter?
lbarber
Member
Well, saludable, after I use a 2-3 bottles, I plan on writing a review of the product... Can't say If I'm feeling much now; I believe it may be helping me in the endurance department! 
But then again, looking at what supplements I use, I also have body octane/powerfull/AP/poseidon, and excell contributing to that...
I will say, however, I had a stuffy nose a while back at night, and the only supplement I dosed before hand with my last meal was sirplus... About an hour later, the stuffy nose had went away, and when I woke up in the morning, I could breath nice and easily...
Other then that, I haven't been sick at all since starting my supplemenation with it, but then again, I don't get sick too often, and if I do feel something coming on, I tend to start incorporating my usage of Free form bcaas on off days...
But yeah, I'm still on the whim about its effects... But seeing how I've responded to AP, Powerfull, and super cissus, as well as the old cissus rx, I'm confident that's helping me from a health standpoint, but I think this is one of those supplements that gets better with time... I have 3 bottles to go through, so we'll how things go... ttyl,
Frank
But then again, looking at what supplements I use, I also have body octane/powerfull/AP/poseidon, and excell contributing to that... I will say, however, I had a stuffy nose a while back at night, and the only supplement I dosed before hand with my last meal was sirplus... About an hour later, the stuffy nose had went away, and when I woke up in the morning, I could breath nice and easily...
Other then that, I haven't been sick at all since starting my supplemenation with it, but then again, I don't get sick too often, and if I do feel something coming on, I tend to start incorporating my usage of Free form bcaas on off days...
But yeah, I'm still on the whim about its effects... But seeing how I've responded to AP, Powerfull, and super cissus, as well as the old cissus rx, I'm confident that's helping me from a health standpoint, but I think this is one of those supplements that gets better with time... I have 3 bottles to go through, so we'll how things go... ttyl,
Frank
lennoxchi
Well-known member
i've been useing for about 2 and a half weeks now. nothing new to report in the DOMs dept. or being able to lift longer....or really nothing new in any area.....i'm realitivly young though and don't expect much joint or bone stiffness or soreness until later in life due to the high threshold for pain that i have