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    Resveratrol is estrogenic at the estrogen receptor beta subtype, anti-estrogenic at the estrogen receptor alpha subtype. Just as compounds such as tamoxifen and clomiphene.


    _J Nutr._ (javascript:AL_get(this, 'jour', 'J Nutr.') 2005
    Apr;135(4):757-60.
    (http://www.ncbi.nlm.nih.gov/entrez/u...gi/pmidlookup?
    view=long&pmid=15795430) _Links_ (javascript:PopUpMenu2_Set(Men u15795430)

    trans-Resveratrol, a natural antioxidant from grapes, increases sperm output
    in healthy rats.
    * _Juan ME_
    (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Searc h&itool=pubmed_AbstractPlus&te rm="Juan+ME"[Author]) ,
    * _Gonzalez-Pons E_
    (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Searc h&itool=pubmed_AbstractPlus&te rm="Gonzalez-Pons+E"[Author]) ,
    * _Munuera T_
    (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Searc h&itool=pubmed_AbstractPlus&te rm="Munuera+T"[Author]) ,
    * _Ballester J_
    (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Searc h&itool=pubmed_AbstractPlus&te rm="Ballester+J"[Author]) ,
    * _Rodriguez-Gil JE_
    (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Searc h&itool=pubmed_AbstractPlus&te rm="Rodriguez-Gil+JE"[Author])
    ,
    * _Planas JM_ (http://w
    ww.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Searc h&itool=pubmed_AbstractPlus&te rm="Planas+JM"[Author]) .
    Departament de Fisiologia, Facultat de Farmacia, Universitat de Barcelona,
    E-08028 Barcelona, Spain.
    trans-Resveratrol was reported to have health benefits including
    anticarcinogenic effects and protection against cardiovascular disease. One of the
    mechanisms by which it exerts its action is through modulating the estrogen
    response systems. Because estrogen is involved in male reproductive biology, we
    investigated the effect of trans-resveratrol on testis and spermatogenesis.
    Adult male rats were divided into 2 groups. The treated group was administered by
    gavage 20 mg/(kg . d) of trans-resveratrol suspended in 10 g/L of
    carboxymethylcellulose for 90 d, whereas the control group received only
    carboxymethylcellulose during the same period. The relative weight of testes did not differ
    between the groups. However, the diameter of the seminiferous tubules was
    significantly reduced from 437.5 +/- 0.1 mum in the controls to 310.9 +/- 0.1
    mum in the resveratrol-treated rats. This decrease was accompanied by a
    significant increase in tubular density, from 3.20 +/- 0.18 in controls to 6.58 +/-
    0.18 tubules/mm(2) in the treated group. Moreover, sperm counts were
    significantly greater in the resveratrol-treated rats (24.8 +/- 3.30 x 10(7)) than
    in the control group (14.1 +/- 0.80 x 10(7)), but sperm quality did not
    differ. Serum concentrations of gonadotrophins and testosterone were significantly
    higher in the resveratrol-treated group. We identified a novel activity of
    trans-resveratrol. The daily oral administration of this phytochemical to adult
    male rats enhanced sperm production by stimulating the
    hypothalamic-pituitary-gonadal axis, without inducing adverse effects.

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