Inner Circle Sale coming Soon--New PowerFULL and SirPlus

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  1. OK. So, my question remains: what's in SirPlus, specifically?


  2. Quote Originally Posted by tintinet View Post
    OK. So, my question remains: what's in SirPlus, specifically?
    I couldn't find specific amounts on the product, but knowing USP you're getting a better than average dose, and total number of doses, at a good price.

    Now, back to my question: Is it possible SirPlus would ever be sold in bulk through Genera?
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  3. mass props to USP.......just placed my order, great deal and great products.....can hardly wait till the stuff gets here...thx again
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    SirPlus per cap gives

    480mgs 95% curcuminoids
    100mgs of Trans Resveratrol
    20mgs piperine

  5. Quote Originally Posted by USPLabs View Post
    SirPlus per cap gives

    480mgs 95% curcuminoids
    100mgs of Trans Resveratrol
    20mgs piperine
    Be available in bulk ever you think?

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  6. Quote Originally Posted by CDB View Post
    Be available in bulk ever you think?

    I may be wrong, but I don't think it would not be as effective in bulk. I'm guessing that the curcuminoids are there to buffer the Trans Reservatrol from oxidation.

  7. Quote Originally Posted by colkurtz_spf View Post
    I may be wrong, but I don't think it would not be as effective in bulk. I'm guessing that the curcuminoids are there to buffer the Trans Reservatrol from oxidation.
    I thought the claim was oxidation wasn't a big problem with the extract vs pure transresveratrol? Have to read the write up again.

  8. The curcuminoids have been found to have a number of antioxidant activities, including scavenging of such reactive oxygen species as superoxide anions and hydrogen peroxide, inhibition of lipid peroxidation and inhibition of the oxidation of low-density lipoprotein (LDL). The reduced derivative of curcumin, tetrahydrocurcumin, has been found to have even stronger antioxidant activity. Tetrahydrocurcumin may be formed from curcumin following ingestion; however, this is unclear.

    The possible anticarcinogenic activity of curcumin and the other curcuminoids may be accounted for by a few mechanisms. These include inhibition of angiogenesis, upregulation of apoptosis, interference with certain signal transduction pathways that are critical for cell growth and proliferation, inhibition of colonic mucosa cyclooxygenase (COX) and lipoxygenase (LOX) activities and inhibition of farnesyl protein transferase. In addition to its possible activity in preventing malignant transformation and inhibiting tumor growth, curcumin may have antimetastatic potential, as well. In this regard, curcumin has been found to inhibit matrix metalloproteinase-9 in a human hepatocellular carcinoma cell line. The possible anticarcinogenic activity of the curcuminoids may be attributed, at least in part, to their ability to inhibit activation of the transcription factors NF-KappaB and AP-1. Curcuminoids have also been found to target the fibroblast growth factor-2 (FGF-2) angiogenic signaling pathway and inhibit expression of gelatinase B in the angiogenic process.

    In the final analysis, the curcuminoids' antioxidant activity may underlie many of the above mechanisms. Reactive oxygen species (ROS) can activate AP-1 and NF-KappaB. Further, FGF-2 induces AP-1 activation via ROS produced through NADPH oxidase. The curcuminoids, acting as antioxidants, may interfere with the ability of FGF-2 to stimulate AP-1, and they may generally inhibit the activation of NF-KappaB and AP-1.

    The possible anti-inflammatory activity of the curcuminoids may also be accounted for by several mechanisms, including inhibition of COX and LOX, reduction of the release of ROS by stimulated neutrophils, inhibition of AP-1 and NF-KappaB, and inhibition of the activation of the pro-inflammatory cytokines TNF (tumor necrosis factor) -alpha and IL (interleukin)-1 beta.

    Curcumin has modest anti HIV-1 activity. It has been found to inhibit HIV-1 and HIV-2 proteases, HIV-1 LTR (long terminal repeat)-directed gene expression, Tat-mediated transactivation of HIV-1-LTR and HIV-1 integrase. All of these actions have been demonstrated in vitro. There is no evidence that curcumin or the other curcuminoids significantly inhibit the replication of HIV-1 in vivo. The mechanism of the possible hypocholesterolemic effect of the curcuminoids is unclear.

  9. Quote Originally Posted by bigluke39 View Post
    I waited and debated about the SirPlus for 24 hours, and the 48 hours sale went away extremely early. (Like 20-25 hours early.) What gives? The sale was supposed to last all of Tuesday, and Wednesday, well at 6:45AM Wednesday morning, it was gone.
    arrrhh just source the contents of sirplus from BAC. I just noticed that from BAC they have the raws..plus much cheaper too
  10. Guest
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    Quote Originally Posted by raptor2003 View Post
    arrrhh just source the contents of sirplus from BAC. I just noticed that from BAC they have the raws..plus much cheaper too
    $12 dollars resveratrol
    $9.00 curcumin
    $5.00 bioperine

    26 dollars

    USPLabs 29.99 and soon we will have a buy 3 get 1 free.

  11. Quote Originally Posted by USPLabs View Post
    $12 dollars resveratrol
    $9.00 curcumin
    $5.00 bioperine

    26 dollars

    USPLabs 29.99 and soon we will have a buy 3 get 1 free.
    It's listed at 44.95 on the site. I was going to try at $29.99 but decided to wait. It was only up for 24 hours or less at the reduced price. I know $15 isn't a big deal but...

  12. When is the sirplus shipping out?
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