Pf/cissus=Gyno?????

dr ozz

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I read in the other forums that people wrote about cissus and gyno and it made me a little worried. Is this a side-effect that has been reported in many cases? I didn't know cissus and powerfull has estrogenic properties, do they?:jaw:

Oscar

Ps. Im dosing 2/2/2 each + Anagen
 
RenegadeRows

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Honestly, if anything is doing it it's the Powefull. Some users experienced slight signs of gyno with Powerfull. It's because it really works: it really raises test. I recommend incorporating Rebound or ATD @25mg ED to combat possible estrogenic sides.

Could you point me to whatever thread has the Cissus relating to Gyno info??? I've never heard that before.
 
dr ozz

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Ithink the post was called

Post your Cissus Reaction:

Im not sure how to post a link to a post(new on the site)

Oscar
 
Ziricote

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It can aggrivate existing gyno but I've never heard of it causing gyno.
Edit- I'm not sure how cissus could aggrivate gyno or cause it, I don't believe it can...
 
Jayhawkk

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I think almost all these gyno cases are just people with sore nipples and nothing more. I call it a case of Salty nipples. Ever worked out while in a sweaty shirt or ran a long distance and sweat a lot? Shirt and salt from sweat can aggrivate nipples. When I was in the army and had a long ruck march or run I put bandaides over them.
 

Guest

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If you have pre existing gyno, your diet cause "gyno," but if you never had gyno than your diet can not cause gyno.
 
lbarber

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I've used cissus rx and powerfull together, and saw no signs of gyno or increase in test. I've also seen no cases of acne from the products, or anything to that nature.


But note: I'm 17, and have a lot of it already.

The one thing I've noticed while taking powerfull is the impact it has had on my sleep, which has been pretty awesome. With cissus, I noticed a pump feeling (usually in the legs), and increase recovery times.
 

wheels

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I'm using both cissus and powerful as part of my cycle with no signs of gyno ? .The recovery between sets is really quick and I don't feel so tried all the time.
 
skull

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I did a little "research" on the sub and as long as you use powerfull with cissus it should be all good ----cissus is loaded with progestins[part of how it works] but powerfull works as a antiprogestin by raising dopamine levels----trying to get that info from USP very difficult but I BET they wont deni it:study:
 

Guest

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I did a little "research" on the sub and as long as you use powerfull with cissus it should be all good ----cissus is loaded with progestins[part of how it works] but powerfull works as a antiprogestin by raising dopamine levels----trying to get that info from USP very difficult but I BET they wont deni it:study:
I have yet to read research that classifies Cissus as a progestin. Where was the "research" found?

PowerFULL does increase dopamine levels.
 
DeerDeer

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I have yet to read research that classifies Cissus as a progestin. Where was the "research" found?

PowerFULL does increase dopamine levels.
However it is quoted that it has androgenic properties in some of the studies. No?
 
skull

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I have yet to read research that classifies Cissus as a progestin. Where was the "research" found?

PowerFULL does increase dopamine levels.
Bibliographic Information

Active constituents (oxo steroids) of Cissus quadrangularis. Sen, S. P. Dept. Pharmacol., Banaras Hindu Univ., Indian Journal of Pharmacy (1964), 26(9), 247-8. CODEN: IJPAAO ISSN: 0019-5472. Journal written in English. CAN 62:22726 AN 1965:22726 CAPLUS

Abstract

An ether ext. of C. quadrangularis, purified by column chromatography, yielded an oxo steroid, m. 134-6°; Ac deriv. m. 124°. The uv and ir spectra suggested an a,b-unsatd. ketone.

Indexing -- Section 42 (Steroids)

Steroids
(keto, from Cissus quadrangularis)

Spectra, infrared
Spectra, visible and ultraviolet
(of keto steroid from Cissus quadrangularis)

Cissus quadrangularis
(oxo steroid from)

Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-
(nuclear magnetic resonance of)

57-83-0, Progesterone
63-05-8, Androst-4-ene-3,17-dione
152-58-9, Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
600-48-6, Pregn-4-ene-3,20-dione, 6b,11a-dihydroxy-
640-87-9, Pregn-4-ene-3,20-dione, 17,21-dihydroxy-, 21-acetate
803-08-7, Pregn-4-ene-3,20-dione, 15a,17,21-trihydroxy-
1235-92-3, Androst-4-ene-3,17-dione, 7a,14-dihydroxy-
1758-12-9, Pregn-4-ene-3,20-dione, 15a,17,21-trihydroxy-, 15,21-diacetate
1758-13-0, Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-, 21-acetate
1758-14-1, Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-, 15,21-diacetate
1974-64-7, Pregn-4-ene-3,20-dione, 6b,11a-dihydroxy-, diacetate
(nuclear magnetic resonance of)

1758-15-2, Androst-4-ene-3,17-dione, 7a,14-dihydroxy-, 7-acetate
10455-29-5, Androst-4-ene-3,15,17-trione
94963-21-0, Pregn-4-ene-3,15,20-trione, 17,21-dihydroxy-
(prepn. of)
 
DeerDeer

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Bibliographic Information

Active constituents (oxo steroids) of Cissus quadrangularis. Sen, S. P. Dept. Pharmacol., Banaras Hindu Univ., Indian Journal of Pharmacy (1964), 26(9), 247-8. CODEN: IJPAAO ISSN: 0019-5472. Journal written in English. CAN 62:22726 AN 1965:22726 CAPLUS

Abstract

An ether ext. of C. quadrangularis, purified by column chromatography, yielded an oxo steroid, m. 134-6°; Ac deriv. m. 124°. The uv and ir spectra suggested an a,b-unsatd. ketone.

Indexing -- Section 42 (Steroids)

Steroids
(keto, from Cissus quadrangularis)

Spectra, infrared
Spectra, visible and ultraviolet
(of keto steroid from Cissus quadrangularis)

Cissus quadrangularis
(oxo steroid from)

Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-
(nuclear magnetic resonance of)

57-83-0, Progesterone
63-05-8, Androst-4-ene-3,17-dione
152-58-9, Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
600-48-6, Pregn-4-ene-3,20-dione, 6b,11a-dihydroxy-
640-87-9, Pregn-4-ene-3,20-dione, 17,21-dihydroxy-, 21-acetate
803-08-7, Pregn-4-ene-3,20-dione, 15a,17,21-trihydroxy-
1235-92-3, Androst-4-ene-3,17-dione, 7a,14-dihydroxy-
1758-12-9, Pregn-4-ene-3,20-dione, 15a,17,21-trihydroxy-, 15,21-diacetate
1758-13-0, Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-, 21-acetate
1758-14-1, Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-, 15,21-diacetate
1974-64-7, Pregn-4-ene-3,20-dione, 6b,11a-dihydroxy-, diacetate
(nuclear magnetic resonance of)

1758-15-2, Androst-4-ene-3,17-dione, 7a,14-dihydroxy-, 7-acetate
10455-29-5, Androst-4-ene-3,15,17-trione
94963-21-0, Pregn-4-ene-3,15,20-trione, 17,21-dihydroxy-
(prepn. of)
Great info - beat me to the punch! Makes you question its use as pct and explain its anabolic and androgenic potential.

I should get some more data on the properties of each of these components and their metabolites in vivo.
 
skull

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Great info - beat me to the punch! Makes you question its use as post cycle therapy and explain its anabolic and androgenic potential.

I should get some more data on the properties of each of these components and their metabolites in vivo.
---dont get the wrong idea I love cissus I got a cabinet full --nothing better to take after a cycle or by itself---you just gota to know what your dealing with:study:
 
DeerDeer

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---dont get the wrong idea I love cissus I got a cabinet full --nothing better to take after a cycle or by itself---you just gota to know what your dealing with:study:
Great point. I have found it to be a great product as well - but this is important info when considering potential sides and mode of action.
 

Guest

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Bibliographic Information

Active constituents (oxo steroids) of Cissus quadrangularis. Sen, S. P. Dept. Pharmacol., Banaras Hindu Univ., Indian Journal of Pharmacy (1964), 26(9), 247-8. CODEN: IJPAAO ISSN: 0019-5472. Journal written in English. CAN 62:22726 AN 1965:22726 CAPLUS

Abstract

An ether ext. of C. quadrangularis, purified by column chromatography, yielded an oxo steroid, m. 134-6°; Ac deriv. m. 124°. The uv and ir spectra suggested an a,b-unsatd. ketone.

Indexing -- Section 42 (Steroids)

Steroids
(keto, from Cissus quadrangularis)

Spectra, infrared
Spectra, visible and ultraviolet
(of keto steroid from Cissus quadrangularis)

Cissus quadrangularis
(oxo steroid from)

Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-
(nuclear magnetic resonance of)

57-83-0, Progesterone
63-05-8, Androst-4-ene-3,17-dione
152-58-9, Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
600-48-6, Pregn-4-ene-3,20-dione, 6b,11a-dihydroxy-
640-87-9, Pregn-4-ene-3,20-dione, 17,21-dihydroxy-, 21-acetate
803-08-7, Pregn-4-ene-3,20-dione, 15a,17,21-trihydroxy-
1235-92-3, Androst-4-ene-3,17-dione, 7a,14-dihydroxy-
1758-12-9, Pregn-4-ene-3,20-dione, 15a,17,21-trihydroxy-, 15,21-diacetate
1758-13-0, Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-, 21-acetate
1758-14-1, Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-, 15,21-diacetate
1974-64-7, Pregn-4-ene-3,20-dione, 6b,11a-dihydroxy-, diacetate
(nuclear magnetic resonance of)

1758-15-2, Androst-4-ene-3,17-dione, 7a,14-dihydroxy-, 7-acetate
10455-29-5, Androst-4-ene-3,15,17-trione
94963-21-0, Pregn-4-ene-3,15,20-trione, 17,21-dihydroxy-
(prepn. of)
Did you happen to find this at AVANT forum?
 
DeerDeer

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---no---why think its fake?--whats the difference ? you got a great product --people just got to know how ti use it.:icon_lol:
I agree. I feel like we should all know a bit mroe about the products we consume. There is no such thing as magic. :)
 

Guest

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---no---why think its fake?--whats the difference ? you got a great product --people just got to know how ti use it.:icon_lol:
Please link me to the study, However, I have the full-text study and they didn't have access to NMR nor
did they indicate any specific molecule. They used IR spectra and only gave clues to the molecule's identity.
The study was Posted by PA over at Avant. PA claimed it contained androstendione.

We been studing Cissus for over a year and if it where a progestrin it would not be a hidden fact.
 
Bering C

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Just my 2 cents I have been using cissus, powerfull and symetry and pretty high doses for a few months now and have not seen a single sign of gyno. This is just me though.
 
RenegadeRows

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Can somebody post who has gyno or has had it in the past who is dosing Cissus, comment on whether or not it aggrivated them, and @ what doses? I highly doubt cissus alone could CAUSE gyno, whether or not it makes an already established condition worse, I'd like to hear feedback.

I personally haven't seen anybody using Cissus claim it caused a flareup...
 
skull

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Please link me to the study, However, I have the full-text study and they didn't have access to NMR nor
did they indicate any specific molecule. They used IR spectra and only gave clues to the molecule's identity.
The study was Posted by PA over at Avant. PA claimed it contained androstendione.

We been studing Cissus for over a year and if it where a progestrin it would not be a hidden fact.
---sounds like the same,but I found it at BB.com---title does cissus have steroids?---if you prove it wrong that would be fine with me:cheers: [no gyno here just nipple hard on]
 

Guest

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Cissus and PF does not cause gyno!!! The thread at bb.com was a copy and paste job from avant. Pat arnold posted false information..maybe he believed it to be true but it was all FALSE....

I did repeat that earlier in this thread...

What update do you want???
 

Guest

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If you do not believe me Please find that study

Active constituents (oxo steroids) of Cissus quadrangularis. Sen, S. P. Dept. Pharmacol., Banaras Hindu Univ., Indian Journal of Pharmacy (1964), 26(9), 247-8. CODEN: IJPAAO ISSN: 0019-5472. Journal written in English. CAN 62:22726 AN 1965:22726 CAPLUS

Abstract

An ether ext. of C. quadrangularis, purified by column chromatography, yielded an oxo steroid, m. 134-6°; Ac deriv. m. 124°. The uv and ir spectra suggested an a,b-unsatd. ketone.

Once you find that study, Please replicate the below info. I gurantee you can not...

Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-
(nuclear magnetic resonance of)

57-83-0, Progesterone
63-05-8, Androst-4-ene-3,17-dione
152-58-9, Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
600-48-6, Pregn-4-ene-3,20-dione, 6b,11a-dihydroxy-
640-87-9, Pregn-4-ene-3,20-dione, 17,21-dihydroxy-, 21-acetate
803-08-7, Pregn-4-ene-3,20-dione, 15a,17,21-trihydroxy-
1235-92-3, Androst-4-ene-3,17-dione, 7a,14-dihydroxy-
1758-12-9, Pregn-4-ene-3,20-dione, 15a,17,21-trihydroxy-, 15,21-diacetate
1758-13-0, Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-, 21-acetate
1758-14-1, Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-, 15,21-diacetate
1974-64-7, Pregn-4-ene-3,20-dione, 6b,11a-dihydroxy-, diacetate
 
rampage jackson

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FWIW I believe you.....never tried your products (Grad student = Poor...hook me up with YG), but if you're good enough for my retarded half brother Jayhawkk, then you're good enough for me. I also have heard nothing other than the PA and "Tits in a bottle" rant. No actual people comming forward with claims of gyno.
 

PGJPB

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Cissus and PF does not cause gyno!!! The thread at bb.com was a copy and paste job from avant. Pat arnold posted false information..maybe he believed it to be true but it was all FALSE....

I did repeat that earlier in this thread...

What update do you want???
I was using Super Cissus and Powerfull for about 2 weeks and I am so sensitive right now I am freaking out. Nothing I read or heard from you guys about these products said this could happen. Because of this I have no serm or anything on hand because I didn't know this was even remotely possible. I have slight pubertal gyno from years ago that is hardly noticable and if these two products permanently enlarge the problem I don't think I'll ever be using anything outside the realm of creatine ever again.

Note I am not taking anything else. Just your two products.

Anybody else experiencing negatives like myself from Powerfull and Cissus?
 
smutty

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I use them both and have nothing but great things to say about them.
 
treningsfrik75

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I have gyno from puberty and it also grows if i go overboard with carbs in my diet. The lumps start to ich as hell.
I have tried both powerfull and cissus and it has not done anything to my gyno.
I also have gone pretty high on the cissus ( megadose)
Have a 10% half kilo powder from USP.

So i doubt strongly cissus is causing gyno. not for me anyway
 
dadream

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FWIW i have a slight case of gyno and i use about 6grams/day of cissus and it has not made it any worse or better so i wouldn't worry bout it, especially to cause gyno.
 

Colin

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Why don't you just post the full study to clear your Cissus product line of containing progestins?

As you are the one who stands to profit from cissus (and not us/the consumers) I think this is a reasonable request.

Intil then,I will not be using cissus in any form.

I would like to use cissus but cannot do so as I'm unsure as to wether or not progestins will be had along with the benefits of cissus,this which would be a a huge drawback IMO.



If you do not believe me Please find that study

Active constituents (oxo steroids) of Cissus quadrangularis. Sen, S. P. Dept. Pharmacol., Banaras Hindu Univ., Indian Journal of Pharmacy (1964), 26(9), 247-8. CODEN: IJPAAO ISSN: 0019-5472. Journal written in English. CAN 62:22726 AN 1965:22726 CAPLUS

Abstract

An ether ext. of C. quadrangularis, purified by column chromatography, yielded an oxo steroid, m. 134-6°; Ac deriv. m. 124°. The uv and ir spectra suggested an a,b-unsatd. ketone.

Once you find that study, Please replicate the below info. I gurantee you can not...

Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-
(nuclear magnetic resonance of)

57-83-0, Progesterone
63-05-8, Androst-4-ene-3,17-dione
152-58-9, Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
600-48-6, Pregn-4-ene-3,20-dione, 6b,11a-dihydroxy-
640-87-9, Pregn-4-ene-3,20-dione, 17,21-dihydroxy-, 21-acetate
803-08-7, Pregn-4-ene-3,20-dione, 15a,17,21-trihydroxy-
1235-92-3, Androst-4-ene-3,17-dione, 7a,14-dihydroxy-
1758-12-9, Pregn-4-ene-3,20-dione, 15a,17,21-trihydroxy-, 15,21-diacetate
1758-13-0, Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-, 21-acetate
1758-14-1, Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-, 15,21-diacetate
1974-64-7, Pregn-4-ene-3,20-dione, 6b,11a-dihydroxy-, diacetate
 
matthew76

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W T F?

Cissus/PF runs wild through my veins as if it was pumping straight from my heart and I've done nothing but get great results with NO GYNO!

Man, I bet if PA said that Creatine can cure limp-d!ck if you snort it, some people would actually do it. WTF!?!
 

jasonschaffin

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W T F?

Cissus/PF runs wild through my veins as if it was pumping straight from my heart and I've done nothing but get great results with NO GYNO!

Man, I bet if PA said that Creatine can cure limp-d!ck if you snort it, some people would actually do it. WTF!?!
This isn't a PA said so thing. PA posted an abstract with this info. USP says the full text doesn't have this info, but we have not seen the full text. Somebody needs to find it and post it. I read a post from PA awhile ago claiming that after he looked at his own cissus (I think, maybe someone elses) he found no traces of androgens.

P.S. I have used the ol' 5% extract with no problems as well as the 40% primaforce. Will be using the supercissus on my next big bulk to keep the joints strong too. I'm not scared.
 
Mulletsoldier

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It's odd, there is an imposition for a burden of proof here, where the charges lack a leg to stand on.

Colin,

You first provide me with something beyond that single abstract to imply Cissus contains androgens and/or other gyno-inducing constituents, and I will do the legwork to dig up that whole study. If one abstract, unfounded, then legitimately refuted, is enough to sway your use, you should stay away from supplements in general.

I have read probably over 100 studies on Leucine alone and I am still undecided.
 

jasonschaffin

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Ha, maybe I spoke too soon about using cissus. Got this from a Doc on a Lean Bulk

Pharmacologyonline 3: 190-202 (2007) Rao et al. CISSUS QUADRANGULARIS PLANT EXTRACT ENHANCES THE DEVELOPMENT OF CORTICAL BONE AND TRABECULAE IN THE FETAL FEMUR Muddanna S.Rao 1*,Bhagath Kumar P1, Narayana Swamy V.B3,Gopalan Kutty N2, 1Department of Anatomy, KMC Maniple, 2Department of Pharmacology, MCOPSManipal, 3Department of Pharmacognosy, MCOPS Manipal*Address for correspondence: Associate Professor, Dept. of Anatomy, KMC, Manipal, Manipal University, 576104, India, e-mail: [email protected] Summary Traditional recipes for treatment of physical and mental ailments exist in all major ancient civilizations of the world. One such recipe popular in the Indian subcontinentinvolves the use of the extract of Cissus quadrangularis plant .Cissus quadrangularis is ashrub, with thick and fleshy quadrangular stem. The roots and stem are most useful forhealing of fracture of the bones. The question whether the plant Cissus quadrangularis, which is proved to contain phyto-estrogens will increase the bone mass during fetalgrowth is not addressed. Accordingly the objective of the present study was to evaluatethe effect of alcoholic extract of Cissus quadrangularis on the intrauterine growth oftrabeculae in the long bones in rats. Pregnant rats were administered with Ethanol extract of Cissus quadrangularis (CQ), orally, at the dose of 750 mg/kg body weight from 9thday of gestation till delivery. Femur bone of the newborn pups were collected, decalcified and processed for paraffin sectioning. Thickness of cortical bone at mid shaft level,thickness of individual trabeculae were measured using a calibrated ocular micrometer. Results showed a significantly increase in thickness of the cortical bone at mid shaft levelcompared to control rats. The thickness of individual trabecula was increasedsignificantly. The present study demonstrates enhanced bone formation during fetal growth by CQ, which may be related to rich content of calcium, phosphorus and phytoestrogenic property of the plant. Key words: Ossification, Cissus quadrangularis, Cortical bone, Trabeculae,Femur
Phytoestrogenicsteroids have been isolated from Cissus quadrangularis plant (13, 14, 15), has beenshown to influence early regeneration and quick mineralization of bone fracture healing process
The question whether the plant Cissus quadrangularis, which is proved to contain phyto-estrogens will increase the bone mass during fetal growth is not addressed.
In the present experimental study we have reported an increased bone mass in the pups born to the treated pregnant rats. This may be attributed to the phytoestrogenic compounds isolated from this plant (13) which might have altered the maternal estrogen level. The plant extract increased the trabecular density of bone the effect was identical on both male and female pups. Hence data was analyzed together. Alternatively, the phyto-estrogenic compounds or other unidentified chemicalcompounds might have altered the steroidal hormonal levels in the pregnant rats, there byinfluencing the skeleton of the fetus/neonatal pups. Another possibility is that the phytoestrogens present in the plant extract might have crossed the placental barrier and reached the developing fetus and influenced the skeletal system
The calcium ions, phosphorous and phytoestrogens present in this plant extract may be made use in the process of ossification and fracture healing.
Now I know not all phytoestrogens are bad, but we don't know about this one. Especially direct effects in males. I doubt I would use it anytime I would be susceptible(sp) to gyno (on cycle, PCT).
 
Mulletsoldier

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A few things here. Firstly, the vast majority of phyto-oestrogens are non-steroidal, and, what isn't being understood here, is their effect on bone density is being mitigated through non-steroidal pathways; secondly, we have two dominant oestrogen receptor types, alpha, and beta. Phytoestrogens, though this is obviously dependent on the phyto., in question, almost exclusively activate the beta receptor. Beta is mostly expressed in the brain, bone tissue, bladder, and a few other tissues. As well, and this is important, Phytos have EXTREMELY LOW binding affinity, meaning the intrinsic action on an ER1 receptor, if it were to occur, would be very little.

Not to be a ****, but it's easy to accuse/doubt when the necessary research has been conducted. Oestrogen/gyno., is the cancer of the bodybuilding world; everything causes it. The interplay between Alpha/Beta ER and Phytos is complex and nuanced, and it's a misstep to characterize Cissus in this gyno-inducing capacity.

Feel free to do some more research on phytos if you think I am being an ass or pulling your chain.
 
poopypants

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Can somebody post who has gyno or has had it in the past who is dosing Cissus, comment on whether or not it aggrivated them, and @ what doses? I highly doubt cissus alone could CAUSE gyno, whether or not it makes an already established condition worse, I'd like to hear feedback.

I personally haven't seen anybody using Cissus claim it caused a flareup...
I have had severe gyno, most peple following my logs know this, Had it from superdrol and got rid of alot of it with an Epi, torem and HDX2 cycle.... Im now taking 6g's ED of Super Cissus bulk and dont have a SINGLE problem with any kind of flare up or pain, which if it was a truel strong progestin I would know and would be in immense pain like I was with propadrol.

This sounds bogus to me. Powerfull is slightly ANTI-progestenic but thats the extent of the relation to progesterone that I think either of these have. You cant take single persons accounts of gyno flare up for fact, one they might not even have any real gyno and two who knows what else they are taking or have taken in the last couple months???
 

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A few things here. Firstly, the vast majority of phyto-oestrogens are non-steroidal, and, what isn't being understood here, is their effect on bone density is being mitigated through non-steroidal pathways; secondly, we have two dominant oestrogen receptor types, alpha, and beta. Phytoestrogens, though this is obviously dependent on the phyto., in question, almost exclusively activate the beta receptor. Beta is mostly expressed in the brain, bone tissue, bladder, and a few other tissues. As well, and this is important, Phytos have EXTREMELY LOW binding affinity, meaning the intrinsic action on an ER1 receptor, if it were to occur, would be very little.

Not to be a ****, but it's easy to accuse/doubt when the necessary research has been conducted. Oestrogen/gyno., is the cancer of the bodybuilding world; everything causes it. The interplay between Alpha/Beta ER and Phytos is complex and nuanced, and it's a misstep to characterize Cissus in this gyno-inducing capacity.

Feel free to do some more research on phytos if you think I am being an ass or pulling your chain.
You're going to make me quote myself.
Now I know not all phytoestrogens are bad, but we don't know about this one. Especially direct effects in males. I doubt I would use it anytime I would be susceptible(sp) to gyno (on cycle, post cycle therapy).
This was my response since Jacob said:

Please post research proving cissus's phytoestrogenic acitivity.
after he said this:
You are responsible for the creation of a product (I will not be specific), but one ingredient is proven to bind to the ER, but I do not see it your write up, Why is that? I really hate the hypocrisy in the industry. We selectively attack but still have skeletons in the closet. Is that ethical?
Jacob is talking about hypocrisy, calls out a product put out that has a ingredient binding to the ER. Isn't that hypocrisy on his part? Cissus is estrogenic, it's not is his write up. I just want everyone to know.
I do doubt it causes gyno in anyway, but if my bones are not broken I will not need the cissus anyways. We have no medical proof it does anything for ligaments/tendons the use I would have used it for. And we have proof it is estrogenic, how much we don't know. I know I have read posting (almost sure by Jacob, but not positive) not to use Formadrol Extreme for the Diazedin. Why is it that phytoestrogen is bad but it is stupid to think that the one in cissus, with no real research behind might not be. Anybody report gyno from FormExtreme? Not that I have heard of. The more we know the better off we all are.
 

jasonschaffin

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well I can't find the post about diazedin i thought i remembered. anybody know anything about its effects?
 

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You're going to make me quote myself.

This was my response since Jacob said:


after he said this:


Jacob is talking about hypocrisy, calls out a product put out that has a ingredient binding to the ER. Isn't that hypocrisy on his part? Cissus is estrogenic, it's not is his write up. I just want everyone to know.
I do doubt it causes gyno in anyway, but if my bones are not broken I will not need the cissus anyways. We have no medical proof it does anything for ligaments/tendons the use I would have used it for. And we have proof it is estrogenic, how much we don't know. I know I have read posting (almost sure by Jacob, but not positive) not to use Formadrol Extreme for the Diazedin. Why is it that phytoestrogen is bad but it is stupid to think that the one in cissus, with no real research behind might not be. Anybody report gyno from FormExtreme? Not that I have heard of. The more we know the better off we all are.
Whoa whoa whoa.

He is posting 1 study just released in 2007 so please yield on the hypocrisy talk.

We have studies that prove that Cissus also contians Keto Steroids.

Please remember we use SERMS(estrogens) for post cycle theraphy. Instead of jumping to conclusions, Please allow some time for our science team to address the questions instead of reacting so hastely.

On the bright side, Cissus could work as a SERM and has proven independent anabolic properties. The good old DOC just might have given us another positive mechanism of action.
 

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Why don't you just post the full study to clear your Cissus product line of containing progestins?

As you are the one who stands to profit from cissus (and not us/the consumers) I think this is a reasonable request.

Intil then,I will not be using cissus in any form.

I would like to use cissus but cannot do so as I'm unsure as to wether or not progestins will be had along with the benefits of cissus,this which would be a a huge drawback IMO.
All you have to do is look up that study to get your answer.

This addition below was fabricated. You can find the old post at mind and muscle or avant..not sure

Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-
(nuclear magnetic resonance of)

57-83-0, Progesterone
63-05-8, Androst-4-ene-3,17-dione
152-58-9, Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
600-48-6, Pregn-4-ene-3,20-dione, 6b,11a-dihydroxy-
640-87-9, Pregn-4-ene-3,20-dione, 17,21-dihydroxy-, 21-acetate
803-08-7, Pregn-4-ene-3,20-dione, 15a,17,21-trihydroxy-
1235-92-3, Androst-4-ene-3,17-dione, 7a,14-dihydroxy-
1758-12-9, Pregn-4-ene-3,20-dione, 15a,17,21-trihydroxy-, 15,21-diacetate
1758-13-0, Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-, 21-acetate
1758-14-1, Pregn-4-ene-3,20-dione, 15b,17,21-trihydroxy-, 15,21-diacetate
1974-64-7, Pregn-4-ene-3,20-dione, 6b,11a-dihydroxy-, diacetate
 
smutty

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If cissus did cause or agitate gyno there would be a sh*t load of complaints already. I have used it for over a year @ about 3 grams a day with nothing but fantastic things to say about it. My joint pain is greatly reduced and I think it has helped me lose a little bodyfat. Also Powerfull is my favorite supp. Fantastic sleep and great workouts. If only I didn't need to cycle it to keep it working at high levels.
 

Guest

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If cissus did cause or agitate gyno there would be a sh*t load of complaints already. I have used it for over a year @ about 3 grams a day with nothing but fantastic things to say about it. My joint pain is greatly reduced and I think it has helped me lose a little bodyfat. Also Powerfull is my favorite supp. Fantastic sleep and great workouts. If only I didn't need to cycle it to keep it working at high levels.
For me it's easy to deterime that Thousands and thousands of Cissus consumers without reports of GYNO or anything estrogen related over 1 study.

If anything its a SERM effect because the Keto sterones are postively anabolic...no doudt at all.
 
Mulletsoldier

Mulletsoldier

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Jacob is talking about hypocrisy, calls out a product put out that has a ingredient binding to the ER. Isn't that hypocrisy on his part? Cissus is estrogenic, it's not is his write up. I just want everyone to know.
I do doubt it causes gyno in anyway, but if my bones are not broken I will not need the cissus anyways. We have no medical proof it does anything for ligaments/tendons the use I would have used it for. And we have proof it is estrogenic, how much we don't know. I know I have read posting (almost sure by Jacob, but not positive) not to use Formadrol Extreme for the Diazedin. Why is it that phytoestrogen is bad but it is stupid to think that the one in cissus, with no real research behind might not be. Anybody report gyno from FormExtreme? Not that I have heard of. The more we know the better off we all are.
I didn't make you quote anything. You can say "I know not all Phytos are bad", but by saying you wouldn't use it anytime you would be susceptible, you display a lack of knowledge on the subject; phytos have a very low binding affinity to Alpha-1 Receptors, and would be highly unlikely (in most cases) to induce or exacerbate Gyno.
 

Guest

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Cissus is estrogenic, it's not is his write up. I just want everyone to know.
I do doubt it causes gyno in anyway, but if my bones are not broken I will not need the cissus anyways. We have no medical proof it does anything for ligaments/tendons the use I would have used it for. And we have proof it is estrogenic, how much we don't know. I know I have read posting (almost sure by Jacob, but not positive) not to use Formadrol Extreme for the Diazedin. Why is it that phytoestrogen is bad but it is stupid to think that the one in cissus, with no real research behind might not be. Anybody report gyno from FormExtreme? Not that I have heard of. The more we know the better off we all are.
Cissus is estrogenic is not proven. In thr study posted it claims Cissus has Phytoestrogens. Again, Nolvadex/clomid is a weak estrogen but does not display unwanted estrogenic effects.

Relax guys, the sky is not falling.
 
poopypants

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Cissus is estrogenic is not proven. In thr study posted it claims Cissus has Phytoestrogens. Again, Nolvadex/clomid is a weak estrogen but does not display unwanted estrogenic effects.

Relax guys, the sky is not falling.
Im not worried, like I said I have a documented history with gyno on this board and if I were taking 6's ED of cissus and it had estrogenic effects/sides it would be quite apparent in my persons and its far from it. Although JC you cant find anything regarding ligement regrowth with cissus and only bone growth I can attest from personal use that the second I discontinue Cissus use I have severe joint discomfort and also when I severely injured myself at the beginning of Jan (check my log and the chat log labeled "when the boss is away") that I used cissus in place of motrin and recovered from wearing a brace to even pick up my 25lb child out of his crib to leg pressing and squating 220lbs and 145lbs respectively for reps without discomfort or pain and can carry satallite dishes up a 28ft ladder now for work with no issue whatsoever.

That injury was one that puts most out for a month or two. I was limited for a week with cissus being used and experienced no est. sides. Im sorry but this compound has NO est. sides, only est benifits, if anything, where its affinity whatesoever for the receptor must be one of a non active nature like a SERM like jacob mentioned, or the same effect Epi had/has.

Why take one abstract unfounded "study/report" over hundreds of peoples feedback and the full untainted study out there for CQ? Thousand of customers dont buy this for its benifits with worries of est sides and 10's -hundreds of companies dont include it in one supplement or another as an active or a filler(ie many ph's that use CQ as a filler) cause they know it will only have positive effects. Not based on unfounded reports of others wanting to discredit the supp for its popularity and nothing else.

Dont be so niave, and if you ersonally really have a problem then go ahead and hold out till your sure for yourself that its an unfounded opinoin/speculation before you take it and dont throw hearsay out as fact. I dont mind the extra stock being available for me to order.
 

Guest

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Ha, maybe I spoke too soon about using cissus. Got this from a Doc on a Lean Bulk






Now I know not all phytoestrogens are bad, but we don't know about this one. Especially direct effects in males. I doubt I would use it anytime I would be susceptible(sp) to gyno (on cycle, post cycle therapy).
First off, "estrogenic" doesn't mean "bad". It's also dependent upon the receptor subtype. SERMs like clomiphene and tamoxifen are estrogenic depending upon the tissue and more specifically, the estrogen receptor subtype found in that tissue. They are estrogenic in tissues like bone (ER-beta) and this is good. They are also anti-estrogenic in other tissues such as breast tissue and the hypothalamus/pituitary, generally associated with the ER-alpha subtype.

He's posting abstracts stating that certain fractions of CQ may have estrogenic activity, but I only see it referenced to bone which is associated with the ER-beta subtype, not the ER-alpha which is more of the true concern and which that Eucommia ulmoides has been shown to interact with.

Agonism at the ER-beta subtype certainly isn't a bad thing as one can see its associated with many of the benefits of estrogens, including bone health. This is the same for raloxifene, tamoxifen, clomiphene. These work to agonize the ER-beta as well.

He's actually making for some good support for you. Estrogens and really all hormones aren't "good" or "bad" but one might view them as that for bodybuilding purposes, but nonetheless, one must consider which receptor subtype they're talking about.

Of course, he should know this so it makes me think he's just trying to be a jerkoff.
 
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