I just mention the saponins of Chlorophytum
Yes, and your point?
Steroidal saponins, according to the Southwest School of Botany, are a plant constituent or a secondary metabolite that helps the body create steroids to stimulate muscle growth and raise testosterone levels.
And?
natural steoroids may produce many of the same side effects as synthetic hormones, including impaired bone-lenght growth, liver damage and increased risk of hormone-related cancers. such as prostate and breast cancer later in life.
Interesting. I would love to see some evidence for this claim, despite the fact you are speaking in wildly
general terms about a
specific plant.
Dr. Mitchell Harman, a growth hormone researcher, says that use of human growth hormone in large doses is "clearly toxic," and that high HGH doses can cause the development of acromegaly, a condition in which the hands, feet and forehead become enlarged, bones grow abnormally, and arthritis and heart problems develop.
"Clearly toxic" is an entirely irrelevant term. "Clearly toxic" in what doses, in what tissues, and in what delivery routes? Without those qualifiers, the statement is irrelevant. This is also an attempt to directly analogize the side effects of a purely synthetic compound - despite the fact your listed side effects come associated with no evidence, and are dubious at best - to a plant product which is intended only to increase its natural counterpart.
Again, as with your comments on Safed Musli, drawing conclusions as to the safety of Mucuna pruriens from gross speculation on the effects of synthetic drugs that the plant does not even contain is hardly a reasonable basis for your argument. The Mucuna pruriens plant does not contain growth hormone as is, but instead contains a natural source of L-DOPA, and any debate in terms of its safety would need to be debated on those grounds.
Besides this, you have yet to produce a single piece of evidence which links any of these adverse health consequences to the
plants themselves, in animal or human models, which would be the gold standard with regard to verifying your claims. In addition, the fact that
both of these plants have been used safely for centuries in Aryuveda, Unani and other traditional medicinal systems almost completely belies your claims. If these were "cancer causing, liver destroying" toxic herbs as you imply here, this extensively detailed traditional history would not exist.
The following are some choice references which detail the safety parameters of MP, CB, synthetic L-DOPA:
Katzenschlager R, et al. “Mucuna pruriens in Parkinson's Disease: A Double Blind Clinical and Pharmacological Study.” Journal of Neurosurgery and Psychiatry, 2004: (75). 1672-1677
Chihara et al. “L-Dopa Stimulates Release of Hypothalamic Growth Hormone- Releasing Hormone in Humans.” Journal of Clinical Endocrinology and Metabolism, 1986: (62) 3. 466-473
Mitsuhashi, S et al. “Effect of Oral Administration of L-Dopa on the Plasma Levels of Growth Hormone-Releasing Hormone (GHRH) in Normal Subjects and Patients with Various Endocrine and Metabolic Diseases.” Nippon Naibunpi Gakkai Zasshi. 1987: (63) 8.934-46.
Mahajani, S.S, et al. “Bioavailability of L-DOPA from HP-200 - A Formulation of Seed Powder of Mucuna pruriens (Bak): A Pharmacokinetic and Pharmacodynamic Study.” Phytotherapy Research, 1996: (10). 245-256.
Sabbe B, et al. “Psychomotor, Neuroendocrine and Behavioural Effects After Oral Administration of Levodopa in Normal Volunteers.” Psychiatry Research, 2004: (128) 1. 128-136.
K.K., Shukla et al. “Mucuna pruriens Improves Male Fertility by Its Action on the Hypothalamus-pituitary-gonadal-axis.” Fertil Steril. 2008 Oct 28. [Epub ahead of print]
Greenspan SL, et al. “Dopaminergic Regulation of Gonadotropin and Thyrotropin Hormone Secretion is Altered With Age. Hormonal Research, 1991: (36) 1-2. 41-46.
Lin, T and Tucci, JR. “Provocative Tests of Growth-Hormone Release. A Comparison of Results With Seven Stimuli. Annuls of Internal Medicine,1974: (80) 4. 464-9
Shukla KK, et al. “Mucuna pruriens Reduces Stress and Improves the Quality of Semen in Infertile Men.” Evidence Based Alternative and Complimentary Medicine, 2007: Dec 18. [Epub ahead of print]
Thakur M, et al. “A Comparative Study on Aphrodisiac Activity of Some Ayurvedic Herbs in Male Albino Rats.” Archive of Sexual Behavior, 2009 Jan 13. [Epub ahead of print] DOI 10.1007/s10508-008-9444-8.
Ahmad, Mohammed-Kaleem et al. “Effect of Mucuna pruriens on Semen Profile and Biochemical Parameters in Seminal Plasma of Infertile Men.” University of Lucknow, India. 2009.
Adepoju, GKA and Odubena, OO. “Effect of Mucuna pruriens on Some Haematological and Biochemical Parameters.” Journal of Medicinal Plants Research, 2009. 3(2). 73-76.
Libert, Mary-Anne. “An Alternative Medicine Treatment for Parkinson's Disease: Results of a Multicenter Clinical Trial HP-200 in Parkinson's Disease Study Group.” Journal of Alternative and Complementary Medicine, 1995. (1) 3. 249-55.
Nikam and Chavan. “Chlorophytum borivilianum (Safed musli): A Review.” Pharmacognosy Review, 2009. (3) 5. 154-169.
Thakur, Mayank et al. “Immunomodulatory Activity of Chlorophytum borivilianum Sant. F.” Evidence Based Alternative and Complementary Medicine, 2007. (4) 4. 419-423.
NP Visavadiya and AVRL Narasimhacharya. “Ameliorative Effect of Chlorophytum borivallanum Root on Lipid Metabolism in Hyperlipaemic Rats.” Clinical and Experimental Pharmacology and Physiology, 2007. 34. 244–249
It is interesting to note that these data collectively fail to suggest the serious adverse events you list here as possible side effects of these plants.
''In all the data I have seen, there were no serious adverse responses in the, and the most common side effects of excitability and sleeplessness occurred in only a small proportion (<3%) of subjects. This holds true for geranium extract as well.''
Sources?
Very ironic. At any rate, the following review should serve as a good start.
View attachment SCHISANDRA.pdf
''Link?''
/forum/usp-labs/35271-powerfull-gave-me.html
/forum/usp-labs/101332-usplabs-powerfull-f-7.html
Your references are
one unverified instance, five years ago, and another post which vaguely alludes to it.
