acshadow
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Conclusion:
A low carbohydrate diet alters cortisol metabolism independently of weight loss. In obese men, this enhances cortisol regeneration by 11-HSD1 and reduces cortisol inactivation by A-ring reductases in liver without affecting subcutaneous adipose 11-HSD1.
Objective: To test effects of dietary macronutrients on cortisol metabolism in obese men.
Context: Dietary macronutrient composition influences cardio-metabolic health independently of obesity. Both dietary fat and insulin alter glucocorticoid metabolism in rodents and, acutely, in humans. However, whether longer-term differences in dietary macronutrients affect cortisol metabolism in humans and contribute to the tissue-specific dysregulation of cortisol metabolism in obesity is unknown.
Design: Two randomized crossover studies.
Participants: Healthy obese men.
Interventions, Outcome Measures and Results:
17 obese men received 4 weeks ad libitum high fat-low carbohydrate (HF-LC) (66% fat, 4% carbohydrate) versus moderate fat-moderate carbohydrate (MF-MC) diets (35% fat, 35% carbohydrate). 6 obese men participated in a similar study with isocaloric feeding. Both HF-LC and MF-MC diets induced weight loss. During 9,11,12,12-[2H]4-cortisol infusion, HF-LC but not MF-MC increased 11-HSD1 activity (rates of appearance of cortisol and 9,12,12-[2H]3-cortisol) and reduced urinary excretion of 5- and 5-reduced [2H]4-cortisol metabolites and [2H]4-cortisol clearance. HF-LC also reduced 24 h urinary 5- and 5-reduced endogenous cortisol metabolites, but did not alter plasma cortisol or diurnal salivary cortisol rhythm. In subcutaneous abdominal adipose tissue, 11-HSD1 mRNA and activity were unaffected by diet.
looks like low carb diets increase 11b-HSD1
(crossposted from M&M)
A low carbohydrate diet alters cortisol metabolism independently of weight loss. In obese men, this enhances cortisol regeneration by 11-HSD1 and reduces cortisol inactivation by A-ring reductases in liver without affecting subcutaneous adipose 11-HSD1.
Objective: To test effects of dietary macronutrients on cortisol metabolism in obese men.
Context: Dietary macronutrient composition influences cardio-metabolic health independently of obesity. Both dietary fat and insulin alter glucocorticoid metabolism in rodents and, acutely, in humans. However, whether longer-term differences in dietary macronutrients affect cortisol metabolism in humans and contribute to the tissue-specific dysregulation of cortisol metabolism in obesity is unknown.
Design: Two randomized crossover studies.
Participants: Healthy obese men.
Interventions, Outcome Measures and Results:
17 obese men received 4 weeks ad libitum high fat-low carbohydrate (HF-LC) (66% fat, 4% carbohydrate) versus moderate fat-moderate carbohydrate (MF-MC) diets (35% fat, 35% carbohydrate). 6 obese men participated in a similar study with isocaloric feeding. Both HF-LC and MF-MC diets induced weight loss. During 9,11,12,12-[2H]4-cortisol infusion, HF-LC but not MF-MC increased 11-HSD1 activity (rates of appearance of cortisol and 9,12,12-[2H]3-cortisol) and reduced urinary excretion of 5- and 5-reduced [2H]4-cortisol metabolites and [2H]4-cortisol clearance. HF-LC also reduced 24 h urinary 5- and 5-reduced endogenous cortisol metabolites, but did not alter plasma cortisol or diurnal salivary cortisol rhythm. In subcutaneous abdominal adipose tissue, 11-HSD1 mRNA and activity were unaffected by diet.
looks like low carb diets increase 11b-HSD1
(crossposted from M&M)
