You do have a point gluconeogenisis would be increased while on T3. The only way to counter these effects is with some sort of anabolic and I don't think Prime fits that description. So if you are looking for Prime to take place of an anabolic to counter muscle wasting it will not work. However, it will keep your strength gains elevated. It's worth a shot to PM a USP rep to see if they know anything we don't about Prime.