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Prime and EndoAmp--a bad idea.

Pace2

New member
I've used Prime several times and really liked it. This time I decided to do 3x3 per day and see how it works. I've been on it just over a week and can tell the difference, but started to get slight lethargy--nothing too bad. Then yesterday I took some EndoAmp from primordial performance (lowers cortisol) and wham, within hours I was super tired, body aches, and chills.

My theory is that cortisol levels were way too low. Prime is thought to be an anti-glucocorticoid, which lowers cortisol. In this case the two proved way too powerful. I stopped endoamp and moved down prime to 2x3 per day. More evidence of Prime's method of action.

I've read people doing 4x3 per day of prime, are they getting lethargy and low cortisol sympotoms?
 
Pace2 said:
I've used Prime several times and really liked it. This time I decided to do 3x3 per day and see how it works. I've been on it just over a week and can tell the difference, but started to get slight lethargy--nothing too bad. Then yesterday I took some EndoAmp from primordial performance (lowers cortisol) and wham, within hours I was super tired, body aches, and chills.

My theory is that cortisol levels were way too low. Prime is thought to be an anti-glucocorticoid, which lowers cortisol. In this case the two proved way too powerful. I stopped endoamp and moved down prime to 2x3 per day. More evidence of Prime's method of action.

I've read people doing 4x3 per day of prime, are they getting lethargy and low cortisol sympotoms?
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Interesting, i know Volcom noticed severe lethargy. Didn't the Indigo study find it was non-hormonal though, which would include cortisol?
 
Steveoph said:
Interesting, i know Volcom noticed severe lethargy. Didn't the Indigo study find it was non-hormonal though, which would include cortisol?
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Yeah, the Indigo Biosciences assay all but eliminated glucocorticoid receptor-antagonism as a potential MoA, by testing PRIME against the known glucocorticoid receptor-agonist and corticosteroid, Dexamethasone. I suppose the possibility exists that the glucocorticoid reduction is enzymatic, through 11B-HSD, or possibly an earlier inhibition, such as 21a-hydroxylase, but that is not likely!

Your feedback is interesting nonetheless, Pace! Keep us updated, if you don't mind.
 
Whats still most intriguing to me is how different peoples responses are. Pace2, how old are you and what is your general sleep + stress levels like?
 
I'm 42, on TRT and generally sleep well, but noticed some sleep issues when I was dosing Prime 3x3. I'm going back to 2x3, I'll let you know if things improve. I gave EndoAmp to my wife who has ADDD and high cortisol, and she already likes it. I'm done with it, until I'm off Prime.
 
Very very interesting. Please keep us updated on how things change as you lower dose if you would.

I've got a hunch...
 
Well I stopped the endoamp, so all the symptoms are gone. What is your hunch?

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Steveoph said:
Interesting, i know Volcom noticed severe lethargy. Didn't the Indigo study find it was non-hormonal though, which would include cortisol?
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Severe lethargy alongside severe positive results. The worst case of love/hate EVER! The lethargy I experienced is the only thing stopping me from getting hooked up to an IV drip off that stuff.

I was very surprised I was never accused of fudging my numbers the results were so irrational. At least no one "said it."
 
so has anyone tried prime with other anti-cortisol type agents like 11-oxo, 7-keto, 7-hydroxy etc? even just dosing 100mg vit c every hr :D
 
EasyEJL said:
so has anyone tried prime with other anti-cortisol type agents like 11-oxo, 7-keto, 7-hydroxy etc? even just dosing 100mg vit c every hr :D
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Ascorbic Acid has also been shown to up-regulate genes that are responsible for the mRNA expression of certain sub-units of the nicotinic acetylcholine receptor. Stuff is like magic juice.
 
I was thinking about stacking prime with lean xtreme. I read a thread somewhere that someone stacked it with lean fx and had great results.
 
Mulletsoldier said:
Ascorbic Acid has also been shown to up-regulate genes that are responsible for the mRNA expression of certain sub-units of the nicotinic acetylcholine receptor. Stuff is like magic juice.
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but, more than ~60mg an hour if its not time released is useless. I laugh whenever i see people buying the 1000mg tabs to take 1 a day :D

I got that from studies i was involved in when I worked for Hoffman La Roche's vitamin product R&D lab in the late 80s
 
EasyEJL said:
but, more than ~60mg an hour if its not time released is useless. I laugh whenever i see people buying the 1000mg tabs to take 1 a day :D

I got that from studies i was involved in when I worked for Hoffman La Roche's vitamin product R&D lab in the late 80s
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Definitely. There is/was a Vitamin-C based energy drink sans Caffeine in Canada that used to be sold in small 'one-shot' containers.
 
Yeah, the product i had been working on was these

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so sunkist went with 60mg a piece. Was quite nice, we did flavor testing and stability testing as well, so to get good random samples we ran off a few thousand in each flavor, roughly a 50gal drum of each. so i had a small bucket on my desk, i'd just pop em like breath mints
 
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