Forskolin transdermal for fat burning, tanning, and acne fighting.
- 03-28-2008, 09:53 AM
Forskolin transdermal for fat burning, tanning, and acne fighting.
I'm going to whip up a transdermal forskolin. I am also thinking of adding some yohimbine, I've read that oral vs. trans is equally effective but I can make tons of transdermals and it's easier than capping. I also want to add some kind of antioxidant to the mix, perhaps cat's claw.
Anyone else have any suggestions?
Here are links to a couple articles:
Natural Acne Treatment
Coleus oil was found to more effectively inhibit the growth of skin pathogens including Propionibacterium acnes (associated with acne) 7 , Staphylococcus aureus (a bacterial strain found in infected wounds and skin eruptions including acne) 8 , Staphylococcus epidermis a bacterial strain occurring in a variety of opportunistic bacterial skin infections and in acne.
Rosacea • topical forskolin: possible rub on tan
Another potential way to increase the amount of melanin in the skin is gaining some publicity from a Sep. 21 article in Nature. Whereas melanotan (Clinuvel, epitan) uses a synthetic melanocyte stimulating hormone, forskolin stimulates the production of melanocyte in fair skinned individuals by raising a chemical known as cyclic AMP (cAMP)
- 03-28-2008, 09:59 AM
Does anybody have any of the stronger extracts of forskolin? Anywhere from 40-95%. I would be interested in trading for some of my homebrew TDS(transdermal delivery system).
Otherwise the 20% forskolin we can get from board sponsors will be fine. I have read that forskolin may work synergistically with all the other compounds in coleus forskolli.
03-28-2008, 10:24 AM
Well I am pretty interested to see your results here, I hope you find a stronger extract. The only thing I have seen that was extremely pure was USP's bolic, but that was a limited run supp.
Muscle Pharm Rep
03-28-2008, 02:08 PM
CustomNW told me he was working on getting the 95% stuff again. Of course for the acne fighting it's actually the essential oils in the herb and not the forskolin that is credited. But yeah, if I had 40-50% forskolin then that would be better.
03-28-2008, 02:18 PM
03-29-2008, 12:59 PM
Sounds very interesting. Keep us updated.
I'm interested in your results.
I just have no idea what carrier you'd put this stuff in. Might want to ask the Avant folks.
03-29-2008, 05:25 PM
Forskolin is soluble in dmso and ethanol, I hope Isopropyl alcohol will work because ethanol does irritate the skin.
I have all the supplies to make a hydro alcoholic carrier, kind of like t-gel. I'll just have to play around with the formula and I think it will work.
03-29-2008, 05:46 PM
DMSO is a no-no for me. I used it when I ran 1-test/4-ad a few years ago - really irritated my skin for a long time.
Skulpt I can tolerate for 4 days per week - then I have to use something else.
03-29-2008, 05:49 PM
i've been pondering trying this too, was waiting till I could find over 90% forslean without having to buy a kilo from sabinsa
03-30-2008, 10:59 AM
Yeah I don't want to use dmso either, hopeful isopropyl alcohol will work. I've seen msm used in transdermals before, I don't know how harsh that would be on skin though.
Methylsulfonylmethane (MSM) -- also known as methyl sulfone or dimethylsulfone (DMSO2) -- is an odorless breakdown product of dimethyl sulfoxide (DMSO)
03-31-2008, 05:03 PM
I found 2 similar products on the net where yohimbine was the main ingredient. One was Patrick Arnolds, it was Water, isopropyl alcohol, dmso based. The other one I found only had water and carbomer.
I will use forskolin and greet tea extract in a 2:1 ratio. I am using green tea for the antioxidant EGCG, and a little caffeine kick.
For my TDS I will try something that should be easy on the skin. I guess the formula depends on how well the alcohol and terpenes can dissolve the forskolin. I don't want to use too much alcohol so I'm going to try starting at 20%
isopropyl alcohol 20%
emulsifying wax 10%
extra virgin coconut oil 5% (for lauric acid and skin penetrating enhancer)
extra virgin olive oil 5% (for oleic acid, spe and vit E)
sweet almond oil 5% (for vit B1,B2,B3, B6 and B9)
d-limonene 2.5% (for a natural terpene, vit c and spe)
eucalyptus oil 2.5% (for a natural terpene, antibacterial, and spe)
That formula didn't work and the eucalyptus stinks.
04-04-2008, 09:31 AM
04-05-2008, 11:47 AM
My second batch I am more happy with, but not quite 100% It seemed to work well but it's dark brown. Maybe I should back off on the ammount of forskolin I put in it. In 4 oz of carrier I put in 7 grams forskolin and 3.5g green tea. I rubbed 1/2ml on the back side of my L forearm. It seemed to darken the skin for 5 minutes or so but now there's no significant difference between my other arm.
It has a nice sweet eastern spice smell, there is absolutely no citrus scent from the limonene. In the 1t 4 ad trans I'm using the lemon scent just kills me.
There is no oily residue left on the skin, maybe I can increase the ammount of oil in it and the d-limonene.
It is a little thin for my liking, I like a thicker smoother product.
The formula I used was closer to my tried and true recipe, I didn't want to play around. My first batch with all the water didn't hold too well, I think it seperated from the water and clumped together.
I think for my next experiment I will cut out the water and see what happens.
04-06-2008, 02:35 AM
I have a pretty good formula I think anyone could make. If not for the isopropyl alcohol everything in it is natural. The stuff goes on good, it's thin but doesn't run all over the place. It dries fast, doesn't feel greasy and makes you look tan!
I got it pretty potent for my sample 2oz batch. I put in 5 grams forskolin and 2.5 grams green tea extract. That equates to 125mg per ml.
Here's the ratio's
isopropyl alcohol 40%
emulsifying wax 10%
extra virgin coconut oil 20% (for lauric acid and skin penetrating enhancer)
extra virgin olive oil 10% (for oleic acid, spe and vit E)
sweet almond oil 10% (for vit B1,B2,B3, B6 and B9)
d-limonene 10% (for a natural terpene, vit c and spe)
In a glass jar measure out the alcohol and d-limonene. Then add the forskolin and green tea. Warm it in the microwave for 20 sec, shake until blended.
In a seperate glass jar measure out the oil's and emulsifying wax. Warm it in the microwave in 30 second increments until fully melted.
Re warm the forskolin for 10 sec in the microwave and slowly stir in the oil mix. Stir for 1 minute to get a good emulsion.
The next part I found works best for getting it thicker, otherwise if I just bottle it, it stays very runny. I put the jar in the freezer uncovered for 10-15 minutes until it turns into a thick paste. Then I take it out and let it warm up some it will become thinner. Use a funnel and pour it into your lotion bottle. Voila your done!
Emulsifying wax is very cheap I got mine from snowdriftfarm.com The d-limonene I got at greenterpene. com
Everything else you can get at the grocery store and from board sponsors.
The freezer trick didn't work too well at these ratio's. It did work on my previous batch when I had half the alcohol and much less forkolin. The color was also a medium brown instead of dark brown. It felt too greasy though, like I just got a massage from this chick who likes to use alot of lube.
04-06-2008, 09:42 AM
04-06-2008, 11:57 AM
It's supposed to work pretty well for people. They did not burn as easy and got a deeper tan than normal.
04-11-2008, 04:21 PM
I figured how to get it in a lotion base. I have this lotion base and polymer sp thickener. But whenever I tried adding alcohol in it it would just crash. Now I figured out the trick.
I mix the lotion base with water and add the thickener and mix until I have a thick lotion. Then I mix my forskolin, green tea, limonene, and alcohol together until it's dissolved. Add the oils to that mix, then add it to the lotion base a little at a time and mix until it's fully mixed. It never crashed that way.
I have one batch where I just tried a few grams forskolin and that turned out to look like creamy peanut butter.
I did another batch that had 125 mg per ml, that stuff is dark brown and a little thinner than the peanut butter.
I like this formula better because it's 50% water so it wont be as intense on the skin.
I've been using forskolin for about a week and last night the scale said I was down 5 pounds from before. I don't know how well the scale will measure my progress because I've been on some 1test, 4ad transdermal too.
Today I measured my bf, I got a few measurements saying 8-9% and a few saying 10-11% so I guess I would say I'm in the 9-10% range My waste at the navel was 34"
I do look tanner but still have some bacne.
04-16-2008, 11:23 PM
I am interested to see how this works out because I get a lot of gastric distress from forskolin, but would like to use it for the recomp effects. Plus I could use a tan!
What do you think about adding it to a pre-made transdermal carrier like Penetrate?
04-20-2008, 11:04 PM
04-22-2008, 11:12 PM
04-22-2008, 11:17 PM
Do you know how many ml of the 125mg/ml mix would be roughly the same as 25 mg of Forskolin taken orally?
04-23-2008, 04:54 PM
04-24-2008, 09:55 AM
Yeah I've seen tons of stuff that would work for that when I was researching for things to put in a formula. The easiest idea I have which I haven't tried but think it would work would be to take 4 oz of lotion, pick up some forskolin and some vit b-5 in bulk powder. Try mixing a gram or 2 each with an ounce of isopropyl alcohol in a glass jar, warm it up in the microwave for 30 sec then shake it up to get it mixed. Dump out the lotion in a seperate glass jar and slowly mix in the alcohol solution a little at a time until it fully mixes in. It should hold at that ratio but if it crashes and turns into a liquid you can always bring it back by slowly mixing it into another ounce or two of lotion.Originally Posted by weakestlink
04-24-2008, 10:02 AM
04-24-2008, 10:12 AM
One problem I encountered with my formulas was that I had way more rub off at 125mg per ml when it was in a water based carrier then when I was using just oils and alcohol. So I had to cut the ammount of forskolin down by half and then they both seemed to work about the same.
I've mainly been using forskolin to enhance my 1t 4ad transdermal as a source of cellular energy. Here is why I'm using it.
(D) Source of Cellular Activation Energy
The process by which transdermal drug delivery operates involves moving molecules across chemical and electrical gradients. Under ordinary tonic conditions, the introduction of materials through the skin results in chemical cascades that consume relatively large amounts of energy as the body seeks to defend itself against the challenge. Therefore, the topical transdermal delivery system of the present invention, according to one preferred embodiment, includes a substance which brings stored energy or the stimulus for release of stored energy on a cellular level, thereby minimizing energy- negative reactions, which could lead to sensitization, ACD or anaphylaxis. By including such stored energy substance, there is a multiplied net increase in available cellular energy and, accordingly, the potential acceleration of those reactions which result in the active agent ultimately reaching its target and being effectively utilized by the body.
While the composition may be formulated to utilize adenosine diphosphate (ADP) or nicotinamide adenine dinucleotide (reduced form) (NADH) or flavin adenine dinucleotide (reduced form) (FADH 2 ) such compounds tend to be unstable and, therefore, are often not preferred.
There has been identified a group of botanical compounds which, due, apparently, to so-called signaling mechanisms, induce high concentrations of enzyme-substrate complexes to be formed, such as by activation of the N S (stimulatroy) protein of adenylate cyclase, thereby resulting in cellular levels of adenosine 3′,5′-cyclic monophosphate (cAMP) approaching the maximal limits of cellular cAMP concentration.
In particular, extracts of the plant Coleus Forskholi, and especially, Forskolin, a labdane diterpenoid, have been found to have a particular ability to stimulate the production of cAMP in cells (Refs. 14 and 15). Other extracts of Coleus Forskohli, such as, Colforsin or coleonol, for example, may also be used.
Other examples of activation energy sources for stimulating generation of cAMP, either via precursors or cellular activators, include, for example, methyl anthines, Saikogenin and Saikosaponin, Angelacie dahuricae radix (yielding angelic acid), phelopterin, oxypeucedanin.
Examples of substances which stimulate cellular production of cGMP include acetylcholine, cytidene diphosphocholine and ascorbic acid (Vitamin C).
The amount of the activation energy source will depend on such factors as, for example, the mechanism of action of the active agent, energy of activation (positive or negative) when active agent encounters its intended receptor (to enhance or decrease cAMP or cGMP levels), etc. Generally, suitable amounts of forskolin or acetylcholine or other source of cellular activation energy, will fall within the range of from about 0.001 to about 0. 1%, preferably, from about 0.001 to about 0.01%, more preferably, from about 0.001 to about 0.005%, based on total composition. As will be appreciated by those skilled in the art, cGMP is considered an antagonist for cAMP. cGMP stimulation will generally be appropriate for situations where it is desired to enhance immune function, such as lymphocyte mediated cytotoxicity, during infection, carcinogenesis, etc. Conversely, cAMP stimulation is generally appropriate in situations where immune system modulation is desired.
04-24-2008, 08:36 PM
04-24-2008, 08:58 PM
I was originally planning that but after reading the sticky on it the consesus was it wasn't worth it.
I did find out today that at 60mg per ml forskolin using the emulsifying wax in the formula eliminated almost all the rub off. That was something that was bothering me, and now I think it's working really well. I'm happy.
04-24-2008, 09:15 PM
04-25-2008, 12:29 PM
Sure, It's not quite the final formula I had to tweak it at the end because it crashed(too many liquids) and instead of making more gel to bring it back I just threw in some wax, it worked the best to date. It's flawed because I overflowed my 10 oz bottle. It yeilds 10.4 oz
If you find my thread "Thinking of making my own transdermal carrier" at the end of the thread I have explained the different phases of how I mix it together. I think the best way to do it would be to mix the emulsion with the solvent then add the solvent to the gel.
polymer sp thickner(sodium polyacrylate) .4oz
91% isopropyl alcohol 2oz
propylene glycol .8oz
green tea 5g
emulsifying wax .8oz
extra virgin organic cocounut oil .2oz
extra virgin olive oil .2oz
sweet almond oil .2oz
04-25-2008, 12:51 PM
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