Your Endo
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Ok, I have a burning issue on my mind and I need some resolve.
After much research and reading of several different threads concerning vasodilation and enhancement in transdermals, I am a confused.
Here is what I understand from my research:
1. Steroids applied topically are vasorestrictive. (unfortunately)
2. When heat (heating pad) is applied to topically applied steroids then the systematic absorption rate is improved nearly 110% by the way of increased blood flow (vasodilatation)
3. Steroids move past the stratum corneum, past the epidermis and eventually into the thick layered dermis.
4. With the application of AAS we are ultimately looking for systematic not localized absorption.
Now, what I am confused on is the “rate limiting step”. I thought that once the steroid gets to the dermis the systematic absorption rate in entirely dependant upon the drug being carried from the dermis into the blood stream (i.e. the rate limiting step).
However, from the responses of Par Deus and Chemo on various forums, I understand that they think the rate limiting step is NOT absorption from the dermis but diffusion through the epidermis or stratum corneum into the dermis. Do steroid freely pass into the blood once they hit the dermis?
Being that steroids are naturally vasorestrictive I would assume absorption from the dermis is slow and indeed hindered by lack of blood flow. Even with the application of ionotophoresis when drugs are practically poured into the skin, systematic absorption is still limited by rate of the dermis.
My point being, if in fact the rate limiting step is the final partitioning from the dermis into the blood stream then topical vasodialators (niacin, capsaicin, ginger, ect.) would prove to be a very worthy and effective addition to a TD formula.
So I ask you, what is the rate limiting step in a transdermal solution? -Your Endo
After much research and reading of several different threads concerning vasodilation and enhancement in transdermals, I am a confused.
Here is what I understand from my research:
1. Steroids applied topically are vasorestrictive. (unfortunately)
2. When heat (heating pad) is applied to topically applied steroids then the systematic absorption rate is improved nearly 110% by the way of increased blood flow (vasodilatation)
3. Steroids move past the stratum corneum, past the epidermis and eventually into the thick layered dermis.
4. With the application of AAS we are ultimately looking for systematic not localized absorption.
Now, what I am confused on is the “rate limiting step”. I thought that once the steroid gets to the dermis the systematic absorption rate in entirely dependant upon the drug being carried from the dermis into the blood stream (i.e. the rate limiting step).
However, from the responses of Par Deus and Chemo on various forums, I understand that they think the rate limiting step is NOT absorption from the dermis but diffusion through the epidermis or stratum corneum into the dermis. Do steroid freely pass into the blood once they hit the dermis?
Being that steroids are naturally vasorestrictive I would assume absorption from the dermis is slow and indeed hindered by lack of blood flow. Even with the application of ionotophoresis when drugs are practically poured into the skin, systematic absorption is still limited by rate of the dermis.
My point being, if in fact the rate limiting step is the final partitioning from the dermis into the blood stream then topical vasodialators (niacin, capsaicin, ginger, ect.) would prove to be a very worthy and effective addition to a TD formula.
So I ask you, what is the rate limiting step in a transdermal solution? -Your Endo
