Your Endo
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Here is a study (abstract) regarding heat and the transdermal delivery of testosterone>
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11402637&dopt=Abstract
One can see that the systematic absorption increased by about 120% over just using the patch alone. Unfortunately, I do not have the full version of the study to refer to. So, we must assume that the reason for the increased absorption was from the increased blood flow to the surface of the skin (vasodilatation).
Now, here is a link to a study about some of capsaicin’s biological properties (full text). Keep in mind that they are referring to injection not topical administration>
http://ajpregu.physiology.org/cgi/content/full/275/1/R92?maxtoshow=&HITS=&hits=&RESULTFORMAT=&fulltext=capsaicin+heat+production&searchid=1061368713878_1861&stored_search=&FIRSTINDEX=0&resourcetype=1
The property that we see again is the vasodilatation effect. Meaning there is a great extravasation into the upper layers of the skin tissue.
Remember, once you get your testosterone past the epidermis it enters the dermis. No mater how much testosterone or AAS you stuff into the skin past the epidermis (diffusion coefficient) whether its through the process of iontophoresis, ultrasound, mechanical penetration, or chemical penetration the process is eventually stalled by the dermis. So the rate of testosterone absorbed systematically is ultimately limited by the rate of absorption (partition coefficient) from the lower layered dermis.
I believe that if capsaisin was implemented into a transdermal formula (.075%) then systematic absorption could be possibly be enhanced by more than 100% with current topical technology.
So, wadda think? Lets get some intelligent conversation going. –Your Endo
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11402637&dopt=Abstract
One can see that the systematic absorption increased by about 120% over just using the patch alone. Unfortunately, I do not have the full version of the study to refer to. So, we must assume that the reason for the increased absorption was from the increased blood flow to the surface of the skin (vasodilatation).
Now, here is a link to a study about some of capsaicin’s biological properties (full text). Keep in mind that they are referring to injection not topical administration>
http://ajpregu.physiology.org/cgi/content/full/275/1/R92?maxtoshow=&HITS=&hits=&RESULTFORMAT=&fulltext=capsaicin+heat+production&searchid=1061368713878_1861&stored_search=&FIRSTINDEX=0&resourcetype=1
The property that we see again is the vasodilatation effect. Meaning there is a great extravasation into the upper layers of the skin tissue.
Remember, once you get your testosterone past the epidermis it enters the dermis. No mater how much testosterone or AAS you stuff into the skin past the epidermis (diffusion coefficient) whether its through the process of iontophoresis, ultrasound, mechanical penetration, or chemical penetration the process is eventually stalled by the dermis. So the rate of testosterone absorbed systematically is ultimately limited by the rate of absorption (partition coefficient) from the lower layered dermis.
I believe that if capsaisin was implemented into a transdermal formula (.075%) then systematic absorption could be possibly be enhanced by more than 100% with current topical technology.
So, wadda think? Lets get some intelligent conversation going. –Your Endo