Penetrate is no different than the other carriers as far a the hepatoxicity.
As far a TD, it is good because it is DIRT CHEAP, arrives fast. My feelings are it probably doesn't do quite as well as phlo jel for absorbtion, but pretty close.
The main issue I have with penetrate is that you run out of sites to apply it to because the alcohol based formula dries you skin out, thus further reducing absorbtion.
On the other hand the alcohol based formula dries very fast, and if you have those grainy base powders (which suddenly have become hard to find), they make it easy to compound.