study: heat applied to TDS

Jason_L

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http://jrnlappliedresearch.com/articles/Vol2Iss1/Hull.htm

CONCLUSION

The many cited studies of transdermal and subcutaneous drug administration indicate that the total amount of drug absorbed, and the consequent plasma drug concentrations increased during heat exposure. Although numerous, more complex mechanisms may be involved, heat is expected to increase skin permeability, blood vessel wall permeability, rate-limiting membrane permeability, and drug solubility in formulation. In addition, changes in the physicochemical properties of transdermal patches, sweating, and increased hydration of the skin may contribute to the release and diffusion of transdermally administered drugs. The dominant mechanism of this important phenomenon, however, appears to be heat-induced local vasodilation and acceleration of skin blood flow. This mechanism has been seen to affect both drug passage through the skin and diffusion from cutaneous and subcutaneous tissue into the systemic circulation. The several-fold increases in plasma drug concentrations seen in these studies suggest that the application of localized heating may provide a simple and effective method for enhancing the transcutaneous delivery of a wide variety of drugs.


time to bust out one of those ace-bandage-type heating pad? :)
 

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