there are some flawed assumptions in their writeup of the product. The first barier to the skin is the startum corneum - much like the scales on a reptile, this layer is a series of tight fitting "tile-like" cells that create a barrier against pollutants to enter the body through the skin while allowing water (not sweat) to escape. It is the displacement of this water in the dermis that allows the transdermal process to occur. Water occupying the skin is released to allow the drug to saturate the dermis. This is why it is critical to stay hydrated when using transdermals. As for sweat defeating the transdermal process, it is a potential issue, however, not they way they describe it. Sweat glands are burried in the dermis and have outlets the tunnel up to the surface of the skin (pores). The drugs delivered by a transdermal can be thought of to surround these tunnels. Sweat would effectively come up and over the skin. If any drug was on the outer surface of the skin, it could be washed away (rubbed off by clothing) or the vehicle that remained on the outer skin could be dilluted and thus its effectiveness compromised. This is not a problem if you allow the transdermal to remain on the skin for aproximately 2 hours prior to sweating.
If the method of reducing the production of sweat was to block the pores, this same component may also block the delivery of the drug. If the method of reducing the production of sweat was to shut down the sebacious glands, this could have other consequences. If they are speaking of locking in the moisture of the skin with their enhanced delivery method, this may have a similar effect on the drug trying to get in by locking it out.
The transdermal process depends on normal functioning skin.
What I can tell you is this - PhloJel Ultra is the most advanced transdermal vehicle available to compounding pharmacist. It does not contain any Pluronic as this was the cause of skin irritation with many PLO gels. It has penetration enhancers not found in any other transdermal vehicle. It does not dry the skin (which will reduce the delivery of the drug), but instead has excellent cosmetic qualities which keep the skin moist.
Also, PhloJel Ultra has several peer reviewed studies delivering NSAID's and the studies used cadaver skin and not synthetic so I can't be sure what effect this would have on the delivery results. I can tell you that cadaver skin yields real world results.