[TheCrownedOne]

Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application.

Armanini D, Nacamulli D, Francini-Pesenti F, Battagin G, Ragazzi E, Fiore C.

Department of Medical and Surgical Sciences-Endocrinology, University of Padua, Via Ospedale 105, 35100 Padua, Italy.

Cortisol is involved in the distribution and deposition of fat, and its action is regulated by the activity of 11beta-hydroxysteroid dehydrogenase. Glycyrrhetinic acid, the active principle of licorice root, blocks 11beta-hydroxysteroid dehydrogenase type 1, thus reducing the availability of cortisol at the level of adipocytes. We evaluated the effect of topical application of a cream containing glycyrrhetinic acid in the thickness of fat at the level of the thigh. Eighteen healthy women (age range 20-33 years) with normal BMI were randomly allocated to treatment, at the level of the dominant thigh, with a cream containing 2.5% glycyrrhetinic acid (n=9) or with a placebo cream containing the excipients alone (n=9). Before and after 1 month of treatment both the circumference and the thickness of the superficial fat layer of the thighs (by ultrasound analysis) were measured. The circumference and the thickness of the superficial fat layer were significantly reduced in comparison to the controlateral untreated thigh and to control subjects treated with the placebo cream. No changes were observed in blood pressure, plasma renin activity, plasma aldosterone or cortisol. The effect of glycyrrhetinic acid on the thickness of subcutaneous fat was likely related to a block of 11beta-hydroxysteroid dehydrogenase type 1 at the level of fat cells; therefore, glycyrrhetinic acid could be effectively used in the reduction of unwanted local fat accumulation.

PMID: 15894038 [PubMed - in process]

[Carlito]

I am ordering some powder and making my plogel and see if it works. I have also read that GA can elevate blood pressure to some individuals But I'll still try it and post results.

Carlito

[TheCrownedOne]

Wow, I thought no one would ever see this

[Carlito]

Originally Posted by TheCrownedOne

Wow, I thought no one would ever see this

Well I am glad someone started this thread,lol.I've read it at another board and was posted by someone with an good rep ever since I've been on this and now finally decided to get some powder from China and make me my own plogel and see what happens. I'll test it myself in my lower back where I have some stubborn fat.

Carlito

[Snachito]

Werd up Carlito!! I would definitely like to hear feedback on this too!! Good luck with it brother!!

[Carlito]

Originally Posted by Snachito

Werd up Carlito!! I would definitely like to hear feedback on this too!! Good luck with it brother!!

hey hey hey brah !!! you are everywhere ,lol oh yeah I hope I don't miss this time, i've tried it before with no success, there is no real supp or trandermal outhere that really helps reduce subcutaneous body fat with dramatic results and that is whta I am looking for, something that with cardio and the appropiate supps one can get rid of stubborn BF such as in lower back, abdomen, chest, ect...

Later,

Carlito

[Snachito]

I'm a forum whore Carlito!!LOL!

I agree with you as I have used some topical stuff and had marginal results. I would love to see something that really gets in those last stubborn areas that want to hold fat, even though a person could be in single digit BF!! Hopefully this ends up being that one compound that does it!! Much respect to you Carlito!!

[Carlito]

Originally Posted by Snachito

I'm a forum whore Carlito!!LOL!

I agree with you as I have used some topical stuff and had marginal results. I would love to see something that really gets in those last stubborn areas that want to hold fat, even though a person could be in single digit BF!! Hopefully this ends up being that one compound that does it!! Much respect to you Carlito!!

likewise bro

carlito

[Syr]

Anyone's gonna try this before me?
I'm holding for avant carrier #3 but nandi recommended either plojel or DMSO.

[Carlito]

Originally Posted by Syr

Anyone's gonna try this before me?
I'm holding for avant carrier #3 but nandi recommended either plojel or DMSO.

I got the powder coming from China and I already got the plogel...just a few more days.
I am having a few bros testing it on another board, we'll see.

Carlito

[Syr]

Originally Posted by Carlito

I got the powder coming from China and I already got the plogel...just a few more days.
I am having a few bros testing it on another board, we'll see.

Carlito

Which board? CEM?

[Carlito]

Outlawmuscle on the classifieds, I tried to send you a PM but it won't let me.

Carlito

[Onslaught]

Are you kidding me? You DON'T want this stuff to go systemic! Just put it in some Lipoderm.

[Carlito]

Originally Posted by Onslaught

Are you kidding me? You DON'T want this stuff to go systemic!

why not?

[Carlito]

i know it can cause a slight decrease in free test levels and may cause estrogenic effects...

[Onslaught]

Neth J Med. 2005 Apr;63(4):146-8. Related Articles, Links
Click here to read
Severe hypokalaemic paralysis and rhabdomyolysis due to ingestion of liquorice.

van den Bosch AE, van der Klooster JM, Zuidgeest DM, Ouwendijk RJ, Dees A.

Department of Internal Medicine, Ikazia Hospital, Rotterdam, The Netherlands.

Chronic ingestion of liquorice induces a syndrome with findings similar to those in primary hyperaldosteronism. We describe a patient who, with a plasma K+ of 1.8 mmol/l, showed a paralysis and severe rhabdomyolysis after the habitual consumption of natural liquorice. Liquorice has become widely available as a flavouring agent in foods and drugs. It is important for physicians to keep liquorice consumption in mind as a cause for hypokalaemic paralysis and rhabdomyolysis.

Publication Types:

* Case Reports


PMID: 15869043 [PubMed - indexed for MEDLINE]

Exp Clin Endocrinol Diabetes. 2003 Sep;111(6):341-3. Related Articles, Links
Click here to read
Licorice consumption and serum testosterone in healthy man.

Armanini D, Bonanni G, Mattarello MJ, Fiore C, Sartorato P, Palermo M.

Department of Medical and Surgical Sciences - Endocrinology, University of Padua, Padua, Italy. decio.armanini@unipd.it

We have previously found that licorice can reduce serum testosterone in healthy men. These results were not confirmed in another study, where the same amounts of licorice did not decrease salivary testosterone values. In the actual study we treated more cases with the same amount of licorice and reproduced our previous data. The mean testosterone values decreased by 26 % after one week of treatment (p < 0.01). There was also a significant increase in 17-OHP and LH concentrations and a slight, but not significant decrease in free testosterone. Licorice treatment, in addition, did not affect the response of testosterone and 17-OHP to stimulation with beta-HCG.

PMID: 14520600 [PubMed - indexed for MEDLINE]

Steroids. 1994 Feb;59(2):69-73. Related Articles, Links

Comparative aspects of 11 beta-hydroxysteroid dehydrogenase. Testicular 11 beta-hydroxysteroid dehydrogenase: development of a model for the mediation of Leydig cell function by corticosteroids.

Monder C, Hardy MP, Blanchard RJ, Blanchard DC.

Population Council, New York, NY 10021.

It has been shown that stress or disease-induced increases in plasma corticosterone result in diminished testosterone secretion from the testes. This article reviews investigations from our laboratories that explore the role of 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) in this process. It is proposed that the level of 11 beta-OHSD in Leydig cells dictates the level of intracellular glucocorticoid available to the glucocorticoid receptor and thus the potency of corticosteroid as an inhibitor of testosterone secretion. Stressed and unstressed rats were housed under simulated natural conditions in a Visible Burrow System. Stressed animals showed elevated plasma corticosteroid, lowered plasma testosterone, and diminished testicular 11 beta-OHSD, Immunocytochemical analysis showed that only Leydig cells of the rat testis contain 11 beta-OHSD and glucocorticoid receptors. Half-maximal inhibition of testosterone by Leydig cells required 1.5 nM dexamethasone or 0.4 microM corticosterone. Glycyrrhetinic acid, an inhibitor of 11 beta-OHSD, increased the potency of corticosterone, but did not affect dexamethasone based inhibition. The glucocorticoid receptor blocker, RU 486, prevented inhibition by both corticosterone and dexamethasone. Other classes of steroid were not inhibitors of testosterone biosynthesis. Thus, 11 beta-OHSD oxidizes corticosterone to the inactive metabolite 11-dehydrocorticosterone, relieving steroid-dependent inhibition of Leydig cell function. Lowered enzyme activity increases glucocorticoid dependent inhibition of testosterone production. We conclude that the evidence supports a role of 11 beta-OHSD in testosterone secretion by the testes.

Publication Types:

* Review
* Review, Tutorial


PMID: 8191550 [PubMed - indexed for MEDLINE]

Maybe it won't be that bad, but I don't think going the systemic route is what you want anyway.

[Carlito]

Originally Posted by Onslaught

Maybe it won't be that bad, but I don't think going the systemic route is what you want anyway.

I believe just like in the study that it causes reduction of bodyfat ( thick subcutaneous )assuming it goes directly to the 11beta-hydroxysteroid dehydrogenase Type 1 at the level of fat cells.
We'll see. I am not saying this absolutely works but I feel there may be a chance it would, in any event I may add a few more compounds to it to counteract side effects , compounds such as Yohimbine HCL, Long jack/tribulus and 4-hydorxyleucine.

thanks,

Carlito

[Syr]

Originally Posted by Onslaught

Maybe it won't be that bad, but I don't think going the systemic route is what you want anyway.

Just one note. Licorice contains more actives, the other acid one (forgot the name sorry) is the one that cause a drop in test levels and probably the other bad stuff.

BTW there is one problem with the topical application. GA is used to bleach the skin from melanin stains, i think this could cause a problem on tanning.