[pogue]

Originally posted by nightop


Yes, but I believe that the ER would be effectively antagonized from local DHT if simply 5aa was used....?

No idea. The mfg of anactrim might have some data about localized DHT, but when we start using PHs, we're on our own

[nightop]

Originally posted by pogue


No idea. The mfg of anactrim might have some data about localized DHT, but when we start using PHs, we're on our own

ooops nvmd, I was confusing 3-beta with 3-alpha....

I was referring to local conversion of 5aa to DHT (which has ER antagonistic properties).

[volusia40]

It's supposed to be an anti-E. Did it get caught up in the ph ban?

[thesinner]

Just wanted to point out that depending on how your gyno was formed, it may not be an issue of estrogen, but rather an issue of prolactin.

Cabergoline (I hope I spelled that right) and vitamin B6 seem to work wonders for this.

Pyridoxine (B6) has a MW of 167, and although oral administration has worked wonders for me in the past, I'm not knowledgable enough on the subject to say whether or not a localized TD effect would be beneficial for your cause. Just something else to think about when trying to get the nips to shrink back up.

[jonny21]

Originally Posted by thesinner

Just wanted to point out that depending on how your gyno was formed, it may not be an issue of estrogen, but rather an issue of prolactin.

Cabergoline (I hope I spelled that right) and vitamin B6 seem to work wonders for this.

Pyridoxine (B6) has a MW of 167, and although oral administration has worked wonders for me in the past, I'm not knowledgable enough on the subject to say whether or not a localized TD effect would be beneficial for your cause. Just something else to think about when trying to get the nips to shrink back up.

I think you are off on that line of thinking. I believe that gyno is always estrogen related. It can be exacerbated by progesterone.

check out the thread below, posts 24,25 &26 especially:

anti progesterone?

[SwordBurn]

Interesting read....so whats the winning TD formula for gyno?

[Fastflight]

I did some 6-oxo in DMSO and applied it to the gyno, and I diod it befoer by simply mixing Letrozol with PEG and alcohols.

Both worked very well and I´ve got a significant reduction in size, as well as the 6-oxo seems to do very well transdermal as a systemic aromatase inhibitor as well as letro.