17-a methylated compounds will make the molecule more difficult to metabolize by the liver but will also stress the liver due to the fact. However, there has been much research into non-17a methylated protecting groups and several have been identified. The most widely used is the 1-ene double bond group...in our world this equates to 1-test and 1,4-andro both of which has been successfully used orally.Originally Posted by knox
IMO, it would be best to dissolve the 1,4 in whatever convenient solvent you may have (PEG-400, Glycerin, Everclear, etc) rather than capping. It is more accurate and a hell of a lot easier. Now, everyone around here knows that my company makes the T-GEL's so it would be too easy to sway you that way but the fact is it would be in your best interest as a homebrewer to just take the 1,4 orally.
Also, DDD did have a strong argument on transdermal delivery of 1,4-andro but his base was dependent on individual views of inherent activity of unconverted prohormones. In other words, do you believe that prohormones exert anabolic action in the unconverted state? I do...maybe not as much as the parent compound...but does exert some affinity to the receptor as has been demonstrated by a few studies. So, the crux of his argument was that 1,4 or any other prohormone was useless until converted and that time released delivery via transdermal was best to eliminate or reduce enzyme saturation for conversion.